Protein Alignment drk and LYN

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_002341.1
• Gene: LYN / 4067
• HGNCID: 6735
• Length: 512
• Species: Homo sapiens
• Alignment Length: 191
• Identity: 55/191 - (28%)
• Similarity: 103/191 - (53%)
• Gaps: 23/191 - (12%)

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:.:.....|:|||:|.:.:|:|  |:...|::|:  |..|||.|||||:    .::..:|::
Human    69 VALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFF 131

  Fly    63 GRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120
            ..|||.|||:  |......||||||.||:..|.|||||:     ..|.::|:|:.......:::.
Human   132 KDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYIS 196

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYD----FVPQESGELDFRRG 176
            . :.|..:::::::::..:....:.::...:.|:.   |..:|    .:|:||.:|..|.|
Human   197 PRITFPCISDMIKHYQKQADGLCRRLEKACISPKP---QKPWDKDAWEIPRESIKLVKRLG 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	19/50 (38%)
		SH2_Grb2_like	56..149	CDD:199828	26/100 (26%)
		SH3_GRB2_like_C	156..208	CDD:212739	8/25 (32%)
LYN	NP_002341.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		SH3_Lyn	67..122	CDD:212937	20/54 (37%)
		SH2_Src_Lyn	125..225	CDD:198227	26/99 (26%)
		PTKc_Lyn	239..510	CDD:270657	6/16 (38%)