DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and sh3gl3b

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_956475.2	Gene:	sh3gl3b / 393150	ZFINID:	ZDB-GENE-040121-4	Length:	386	Species:	Danio rerio

Alignment Length:	114	Identity:	35/114 - (30%)
Similarity:	52/114 - (45%)	Gaps:	17/114 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 CPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASV-----SRSQDVKLRDMIP--EEMLV 157
            |..|......:.:|.|:.:..||          .||...|     :..:...:.|..|  ::...
Zfish   275 CSSGPSSDTEITEALSEKYAPVV----------VHRPEQVTIKTPTTDKPASINDRAPPLDQPCC 329

  Fly   158 QALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYV 206
            ||||.|..:..|||.|:.||:|.:|.:.||||:.|.|..:.|:||..||
Zfish   330 QALYSFQAENQGELGFKEGDIIILTSQIDENWYEGMIRGQSGLFPMNYV 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738
		SH2_Grb2_like	56..149	CDD:199828	9/53 (17%)
		SH3_GRB2_like_C	156..208	CDD:212739	24/51 (47%)
sh3gl3b	NP_956475.2	BAR_Endophilin_A	25..247	CDD:153276
sh3gl3b	NP_956475.2	SH3_Endophilin_A	327..381	CDD:212737	24/52 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030