DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and fyna

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:NP_001315092.1 Gene:fyna / 373872 ZFINID:ZDB-GENE-030903-5 Length:537 Species:Danio rerio


Alignment Length:215 Identity:68/215 - (31%)
Similarity:115/215 - (53%) Gaps:36/215 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:|:.|.::|:|||||.:..:||| ..:.:|:.|.  ..|..|.|||||:    .::..|||:
Zfish    88 VALYDYEARSEDDLSFRKGEKFQILN-STEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYF 151

  Fly    63 GRITRADAEK-LLSNKH-EGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120
            |::.|.|||: ||||.: .|.||||.||::.|.:|||::     ..|.|:|:|:.:.....:::.
Zfish   152 GKLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDETKGDHVKHYKIRKLDNGGYYIT 216

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDF---------VPQESGELDFRR 175
            . .:|.:|.:||.::.    :|:..:..|.::|....:..|.|.         :|:||.:|..|.
Zfish   217 TRAQFETLQQLVHHYS----ARAAGLCCRLIVPCHKGMPRLADLSVKTKDVWEIPRESLQLIKRL 277

  Fly   176 GDVITVTDRSDENW---WNG 192
            |:     .:..|.|   |||
Zfish   278 GN-----GQFGEVWMGTWNG 292

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 20/50 (40%)
SH2_Grb2_like 56..149 CDD:199828 32/100 (32%)
SH3_GRB2_like_C 156..208 CDD:212739 13/49 (27%)
fynaNP_001315092.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..34
SH3_Fyn_Yrk 85..140 CDD:212939 21/52 (40%)
SH2_Src_Fyn_isoform_a_like 145..245 CDD:198281 33/103 (32%)
PTKc_Fyn 261..534 CDD:270655 11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

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