DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and Itk

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:NP_001102295.2 Gene:Itk / 363577 RGDID:1311618 Length:620 Species:Rattus norvegicus


Alignment Length:155 Identity:44/155 - (28%)
Similarity:83/155 - (53%) Gaps:30/155 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRA-ELDGKEGLIPSNYI------EMKNHDWY 61
            ||.:|:......||:.|:.:...:|: ..:.:|:|. :.:|.||..||:|:      .::.::||
  Rat   177 IALYDYQTNDPQELALRRDEEYYLLD-SSEIHWWRVQDKNGHEGYAPSSYLVEKSPNSLETYEWY 240

  Fly    62 YGRITRADAEK-LLSNKHEGAFLIRISESSPGDFSLSV----------KCPDGVQHF--KVLRDA 113
            ...|:|..||| ||....||||::|.|. :||.:::||          .|   ::|:  |...|:
  Rat   241 NKSISRDKAEKLLLDTGKEGAFMVRDSR-TPGTYTVSVFTKAIISENNPC---IKHYHIKETNDS 301

  Fly   114 QSKFFL---WVVKFNSLNELVEYHR 135
            ..::::   :|  |:|:..|::||:
  Rat   302 PKRYYVAEKYV--FDSIPLLIQYHQ 324

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 14/49 (29%)
SH2_Grb2_like 56..149 CDD:199828 29/96 (30%)
SH3_GRB2_like_C 156..208 CDD:212739
ItkNP_001102295.2 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841 15/52 (29%)
SH2_Tec_Itk 232..340 CDD:198259 29/99 (29%)
PTKc_Itk 358..613 CDD:133243
Blue background indicates that the domain is not in the aligned region.

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