Protein Alignment drk and Cd2ap

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_852140.2
• Gene: Cd2ap / 316258
• RGDID: 727803
• Length: 637
• Species: Rattus norvegicus
• Alignment Length: 217
• Identity: 48/217 - (22%)
• Similarity: 89/217 - (41%)
• Gaps: 57/217 - (26%)

  Fly     1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYI-EMKNHDWYYGR 64
            ::.|.::|:.|..||||:.|..:|::.:....:..|...||:|:.|:.|.|:: |:|.
  Rat     2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKR------- 59

  Fly    65 ITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNE 129
                                   |:.|.|.:|.:|           |:          :..::..
  Rat    60 -----------------------ETEPKDDNLPIK-----------RE----------RPGNVAS 80

  Fly   130 LVEYHRT-----ASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENW 189
            ||:...|     ..:......|......::...:.|:::.||...||:...||||.|.:..:|.|
  Rat    81 LVQRISTYGLPAGGIQPHPQTKAMKKKTKKRQCKVLFEYSPQNEDELELTVGDVIDVIEEVEEGW 145

  Fly   190 WNGEIGNRKGIFPATYVTPYHS 211
            |:|.:.|:.|:||:.:|....|
  Rat   146 WSGTLNNKLGLFPSNFVKELES 167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	16/50 (32%)
		SH2_Grb2_like	56..149	CDD:199828	11/97 (11%)
		SH3_GRB2_like_C	156..208	CDD:212739	19/51 (37%)
Cd2ap	NP_852140.2	Interaction with ANLN and localization to the midbody. /evidence=ECO:0000250	1..175		48/217 (22%)
		SH3_CD2AP_1	3..58	CDD:212986	17/54 (31%)
		SH3_CD2AP_2	111..165	CDD:212987	19/53 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..211		1/1 (100%)
		SH3_CD2AP_3	271..327	CDD:212989
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	333..455
		SH3-binding. /evidence=ECO:0000255	336..352
		SH3-binding. /evidence=ECO:0000255	378..397
		SH3-binding. /evidence=ECO:0000255	410..422
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..556