DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and Lck

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:XP_006238994.1 Gene:Lck / 313050 RGDID:2994 Length:520 Species:Rattus norvegicus


Alignment Length:150 Identity:53/150 - (35%)
Similarity:82/150 - (54%) Gaps:18/150 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYIEMKN----HDWYY 62
            ||.|.:..:.|.:|.|.|.:.|:||  |....|::|:  ..|:||.||.|::...|    ..|::
  Rat    78 IALHSYEPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFF 140

  Fly    63 GRITRADAEKLL---SNKHEGAFLIRISESSPGDFSLSVKCPDG-----VQHFKVLRDAQSKFFL 119
            ..::|.|||:.|   .|.| |:||||.|||:.|.|||||:..|.     |:|:|:.......|::
  Rat   141 KNLSRKDAERQLLAPGNTH-GSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYI 204

  Fly   120 WV-VKFNSLNELVEYHRTAS 138
            .. :.|..|::||.::..||
  Rat   205 SPRITFPGLHDLVRHYTNAS 224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 19/50 (38%)
SH2_Grb2_like 56..149 CDD:199828 33/95 (35%)
SH3_GRB2_like_C 156..208 CDD:212739
LckXP_006238994.1 SH3_Lck 76..129 CDD:212938 19/52 (37%)
SH2_Src_Lck 134..234 CDD:198225 32/91 (35%)
PTKc_Lck_Blk 248..511 CDD:270652
Blue background indicates that the domain is not in the aligned region.

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