DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drk and HCK

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_002101.2	Gene:	HCK / 3055	HGNCID:	4840	Length:	526	Species:	Homo sapiens

Alignment Length:	218	Identity:	60/218 - (27%)
Similarity:	112/218 - (51%)	Gaps:	36/218 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:|:.|...::|||:|...:.:|  |:...|::|.  ...|||.|||||:    .::..:|::
Human    84 VALYDYEAIHHEDLSFQKGDQMVVL--EESGEWWKARSLATRKEGYIPSNYVARVDSLETEEWFF 146

  Fly    63 GRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSV-----KCPDGVQHFKVLRDAQSKFFLW 120
            ..|:|.|||:  |......|:|:||.||::.|.:||||     :..|.|:|:|:.......|::.
Human   147 KGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYIS 211

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMI--PEEMLVQALYDFVPQESGELDFRRGDVITVT 182
            . ..|::|.|||::::..:....|.:.:..|.  |::...:..:: :|:||.:|:.:.|
Human   212 PRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWE-IPRESLKLEKKLG------ 269

  Fly   183 DRSDENWWNGEIGNRKGIFPATY 205
                    .|:.|.   ::.|||
Human   270 --------AGQFGE---VWMATY 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	18/50 (36%)
		SH2_Grb2_like	56..149	CDD:199828	29/100 (29%)
		SH3_GRB2_like_C	156..208	CDD:212739	10/50 (20%)
HCK	NP_002101.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SH3	82..137	CDD:302595	19/54 (35%)
		SH2_Src_HCK	140..243	CDD:198226	29/102 (28%)
		PKc_like	254..524	CDD:304357	10/46 (22%)
		Pkinase_Tyr	262..511	CDD:285015	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910