DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and GRB2

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_002077.1	Gene:	GRB2 / 2885	HGNCID:	4566	Length:	217	Species:	Homo sapiens

Alignment Length:	212	Identity:	139/212 - (65%)
Similarity:	167/212 - (78%)	Gaps:	4/212 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRI 65
            ||||||:||.|||||||||::..|||:||.|.|.|||:|||:||:|.||.||||||.|.|::|:|
Human     1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKI 65

  Fly    66 TRADAEKLLS-NKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNE 129
            .||.||::|| .:|:||||||.|||:|||||||||..:.|||||||||...|:||||||||||||
Human    66 PRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNE 130

  Fly   130 LVEYHRTASVSRSQDVKLRDM--IPEE-MLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWN 191
            ||:|||:.||||:|.:.|||:  :|:: ..||||:||.|||.|||.|||||.|.|.|.||.|||.
Human   131 LVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWK 195

  Fly   192 GEIGNRKGIFPATYVTP 208
            |....:.|:||..||||
Human   196 GACHGQTGMFPRNYVTP 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	35/50 (70%)
		SH2_Grb2_like	56..149	CDD:199828	63/93 (68%)
		SH3_GRB2_like_C	156..208	CDD:212739	31/51 (61%)
GRB2	NP_002077.1	SH3_GRB2_N	1..56	CDD:212879	39/54 (72%)
		SH2_Grb2_like	56..150	CDD:199828	63/93 (68%)
		SH3_GRB2_C	160..212	CDD:212882	31/51 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160170
Domainoid	1	1.000	113	1.000	Domainoid score	I6156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1576
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2889
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46063
OrthoDB	1	1.010	-	-		D1091250at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto90272
orthoMCL	1	0.900	-	-		OOG6_107796
Panther	1	1.100	-	-	LDO	PTHR46037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	1	1.000	-	-		X588
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.940