Protein Alignment drk and ABL2

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 140
• Identity: 50/140 - (35%)
• Similarity: 82/140 - (58%)
• Gaps: 5/140 - (3%)

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYI----EMKNHDWYYGR 64
            :|.:||.|:.|:.||..|.:.|::|....:..|........:|.:|||||    .::.|.||:|.
Human   113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYITPVNSLEKHSWYHGP 177

  Fly    65 ITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWV-VKFNSLN 128
            ::|:.||.|||:...|:||:|.||||||..|:|::....|.|:::...|..|.::.. .:|::|.
Human   178 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLA 242

  Fly   129 ELVEYHRTAS 138
            |||.:|.|.:
Human   243 ELVHHHSTVA 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	15/48 (31%)
		SH2_Grb2_like	56..149	CDD:199828	33/84 (39%)
		SH3_GRB2_like_C	156..208	CDD:212739
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	17/50 (34%)
		SH2_ABL	169..262	CDD:198189	33/84 (39%)
		PTKc_Abl	281..543	CDD:270645
		Kinase activation loop. /evidence=ECO:0000250	427..451
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885