DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drk and Hck

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_037317.2	Gene:	Hck / 25734	RGDID:	2785	Length:	524	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	60/220 - (27%)
Similarity:	109/220 - (49%)	Gaps:	40/220 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:|:.|...::|||:|...:.:|  |:...|::|.  ...|||.|||||:    .::..:|::
  Rat    82 VALYDYEAIHREDLSFQKGDQMVVL--EESGEWWKARSLATKKEGYIPSNYVARVNSLETEEWFF 144

  Fly    63 GRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120
            ..|:|.|||:  |......|:|:||.||::.|.:||||:     ..|.|:|:|:.......|::.
  Rat   145 KGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYIS 209

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYD----FVPQESGELDFRRGDVIT 180
            . ..|:||.|||.:::.......|.:.:..:.|:.   |..::    .:|:||.:::.:.|
  Rat   210 PRSTFSSLQELVVHYKKGKDGLCQKLSVPCVSPKP---QKPWEKDAWEIPRESLQMEKKLG---- 267

  Fly   181 VTDRSDENWWNGEIGNRKGIFPATY 205
                      .|:.|.   ::.|||
  Rat   268 ----------AGQFGE---VWMATY 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	18/50 (36%)
		SH2_Grb2_like	56..149	CDD:199828	30/100 (30%)
		SH3_GRB2_like_C	156..208	CDD:212739	10/54 (19%)
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..71
		SH3	80..135	CDD:302595	19/54 (35%)
		SH2_Src_HCK	138..241	CDD:198226	30/102 (29%)
		PKc_like	252..522	CDD:304357	9/45 (20%)
		Pkinase_Tyr	260..509	CDD:285015	6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910