DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and FYN

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens

Alignment Length:	215	Identity:	65/215 - (30%)
Similarity:	112/215 - (52%)	Gaps:	36/215 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:|:.|..:|:|||.|.:..:||| ..:.:|:.|.  ..|:.|.|||||:    .::..:||:
Human    88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYF 151

  Fly    63 GRITRADAEK-LLS-NKHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120
            |::.|.|||: ||| ....|.||||.||::.|.:|||::     ..|.|:|:|:.:.....:::.
Human   152 GKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYIT 216

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDF---------VPQESGELDFRR 175
            . .:|.:|.:||:::.    .|:..:..|.::|....:..|.|.         :|:||.:|..|.
Human   217 TRAQFETLQQLVQHYS----ERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRL 277

  Fly   176 GDVITVTDRSDENW---WNG 192
            |:     .:..|.|   |||
Human   278 GN-----GQFGEVWMGTWNG 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	19/50 (38%)
		SH2_Grb2_like	56..149	CDD:199828	30/100 (30%)
		SH3_GRB2_like_C	156..208	CDD:212739	13/49 (27%)
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939	20/52 (38%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	31/103 (30%)
		PTKc_Fyn	261..534	CDD:270655	11/37 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910