DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drk and FRK

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens

Alignment Length:	152	Identity:	57/152 - (37%)
Similarity:	85/152 - (55%)	Gaps:	19/152 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAEL----DGK----EGLIPSNYI----EMK 56
            :|..|:.|...::||||....|::|:...:..|:...|    ||.    :|.|||||:    .::
Human    48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQ 112

  Fly    57 NHDWYYGRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSVKCPDG--VQHFKVLRDAQSKF 117
            ...|::|.|.|:||||  |.|....|:||||.|||..|:|||||.  ||  |:|:::.|..:..|
Human   113 AEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVL--DGAVVKHYRIKRLDEGGF 175

  Fly   118 FLWVVK-FNSLNELVEYHRTAS 138
            ||...: |::|||.|.::...|
Human   176 FLTRRRIFSTLNEFVSHYTKTS 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	18/56 (32%)
		SH2_Grb2_like	56..149	CDD:199828	38/88 (43%)
		SH3_GRB2_like_C	156..208	CDD:212739
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	17/55 (31%)
		SH2_Src_Frk	112..207	CDD:199831	38/88 (43%)
		PTKc_Frk_like	225..494	CDD:270653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910