DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and FGR

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:NP_005239.1 Gene:FGR / 2268 HGNCID:3697 Length:529 Species:Homo sapiens


Alignment Length:145 Identity:56/145 - (38%)
Similarity:88/145 - (60%) Gaps:15/145 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            ||.:|:.|..:|:|:|.|.:...||| ..:.:|:.|.  ..||.|.|||||:    .::..:||:
Human    83 IALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYF 146

  Fly    63 GRITRADAEK-LLS-NKHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLR-DAQSKFFL 119
            |:|.|.|||: ||| ...:||||||.||::.|.:|||::     ..|.|:|:|:.: |....:..
Human   147 GKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYIT 211

  Fly   120 WVVKFNSLNELVEYH 134
            ..|:|||:.|||:::
Human   212 TRVQFNSVQELVQHY 226

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 20/50 (40%)
SH2_Grb2_like 56..149 CDD:199828 35/87 (40%)
SH3_GRB2_like_C 156..208 CDD:212739
FGRNP_005239.1 SH3 80..137 CDD:473055 21/54 (39%)
SH2_Src_Fgr 140..240 CDD:198230 35/87 (40%)
Protein Kinases, catalytic domain 267..514 CDD:473864
Blue background indicates that the domain is not in the aligned region.

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