DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and Rasa1

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_663427.2	Gene:	Rasa1 / 218397	MGIID:	97860	Length:	1038	Species:	Mus musculus

Alignment Length:	160	Identity:	41/160 - (25%)
Similarity:	84/160 - (52%)	Gaps:	12/160 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DELSFRKTQILKILN-MEDDSNWYRAELDGKEGLIPSNYIEMKNHD--------WYYGRITRADA 70
            ||:||.|..:..:.| :||...|.......::|||..:.:|....:        |::|:|::.:|
Mouse   288 DEISFLKGDMFIVHNELEDGWMWVTNLRTDEQGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEA 352

  Fly    71 EKLLSNKHE-GAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYH 134
            ..||....: .:||:|.|:::|||:||..:..:.:|.||:.....::|.:....:||:.::::::
Mouse   353 YNLLMTVGQVCSFLVRPSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHY 417

  Fly   135 RTASVSRSQDVKLRDMIPEEMLVQALYDFV 164
            |...:  .:...|::.:|.:...|.|.|.|
Mouse   418 RKEQI--VEGYYLKEPVPMQDQGQVLNDTV 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	12/38 (32%)
		SH2_Grb2_like	56..149	CDD:199828	23/101 (23%)
		SH3_GRB2_like_C	156..208	CDD:212739	4/9 (44%)
Rasa1	NP_663427.2	SH2_Nterm_RasGAP	152..255	CDD:198216
		SH3_RasGAP	272..330	CDD:212722	13/41 (32%)
		SH2_Cterm_RasGAP	341..417	CDD:198217	21/75 (28%)
		PH	480..568	CDD:278594
		PH_RASA1	480..567	CDD:270080
		C2_Ras_p21A1	582..707	CDD:176045
		RasGAP	689..1035	CDD:214617
		RasGAP_p120GAP	705..1036	CDD:213340
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910