DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and Sh3gl2

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_062408.2	Gene:	Sh3gl2 / 20404	MGIID:	700009	Length:	352	Species:	Mus musculus

Alignment Length:	277	Identity:	65/277 - (23%)
Similarity:	102/277 - (36%)	Gaps:	99/277 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EAIAKHDFSATADDELSF------------RKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIE 54
            ||:.|  |.....|:.:|            ..:::...|:||...|:    :|..:.|...:..|
Mouse    95 EAMLK--FGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNF----IDPLQNLHDKDLRE 153

  Fly    55 MKNH---------DWYY-----GRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQ 105
            :::|         |:.|     |:|...:..:.|....|..   .|:|||.  |:|.....:.|.
Mouse   154 IQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESK---EIAESSM--FNLLEMDIEQVS 213

  Fly   106 HFKVLRDAQSKFFLWVVKFNSLNELVEYHRTA-SVSRSQDVKLRDMI------------------ 151
            ....|..||                :|||:.| .:.:...|:|.:.|
Mouse   214 QLSALVQAQ----------------LEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMS 262

  Fly   152 --------------------PEEMLVQ-------ALYDFVPQESGELDFRRGDVITVTDRSDENW 189
                                |:...||       |||||.|:..|||.|:.||:||:|::.||||
Mouse   263 LEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENW 327

  Fly   190 WNGEIGNRKGIFPATYV 206
            :.|.:..:.|.||..||
Mouse   328 YEGMLHGQSGFFPINYV 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	12/62 (19%)
		SH2_Grb2_like	56..149	CDD:199828	23/107 (21%)
		SH3_GRB2_like_C	156..208	CDD:212739	27/58 (47%)
Sh3gl2	NP_062408.2	Binds and tubulates liposomes. /evidence=ECO:0000250	1..125		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Membrane-binding amphipathic helix. /evidence=ECO:0000250	1..21
		BAR_Endophilin_A1	25..247	CDD:153297	37/178 (21%)
		Required for dimerization upon membrane association. /evidence=ECO:0000250	60..87
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..289		1/24 (4%)
		SH3_Endophilin_A	293..347	CDD:212737	25/52 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940