DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment drk and sem-5

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_509342.1	Gene:	sem-5 / 181055	WormBaseID:	WBGene00004774	Length:	228	Species:	Caenorhabditis elegans

Alignment Length:	213	Identity:	130/213 - (61%)
Similarity:	161/213 - (75%)	Gaps:	2/213 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRI 65
            |||:|:|||.|.:.|||||::...||:||.::|.:||:|||||.||.||||||.|...:||.|:|
Worm     1 MEAVAEHDFQAGSPDELSFKRGNTLKVLNKDEDPHWYKAELDGNEGFIPSNYIRMTECNWYLGKI 65

  Fly    66 TRADAEKLLSNK--HEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLN 128
            ||.|||.||...  .:|.||:|..|||||:||:||:..|.|||||||||...|::||.|||||||
Worm    66 TRNDAEVLLKKPTVRDGHFLVRQCESSPGEFSISVRFQDSVQHFKVLRDQNGKYYLWAVKFNSLN 130

  Fly   129 ELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGE 193
            |||.|||||||||:..:.|.||..|...||||:||.|||||||.|:||||||:.::.|.|||.|:
Worm   131 ELVAYHRTASVSRTHTILLSDMNVETKFVQALFDFNPQESGELAFKRGDVITLINKDDPNWWEGQ 195

  Fly   194 IGNRKGIFPATYVTPYHS 211
            :.||:||||:.||.||:|
Worm   196 LNNRRGIFPSNYVCPYNS 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	30/50 (60%)
		SH2_Grb2_like	56..149	CDD:199828	57/94 (61%)
		SH3_GRB2_like_C	156..208	CDD:212739	33/51 (65%)
sem-5	NP_509342.1	SH3_GRB2_like_N	2..53	CDD:212738	30/50 (60%)
		SH2_Grb2_like	56..151	CDD:199828	57/94 (61%)
		SH3_GRB2_like_C	158..210	CDD:212739	33/51 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167664
Domainoid	1	1.000	101	1.000	Domainoid score	I4386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1576
Inparanoid	1	1.050	274	1.000	Inparanoid score	I1801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46063
OrthoDB	1	1.010	-	-		D1091250at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto17724
orthoMCL	1	0.900	-	-		OOG6_107796
Panther	1	1.100	-	-	LDO	PTHR46037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R571
SonicParanoid	1	1.000	-	-		X588
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940