Protein Alignment drk and Hck

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_034537.2
• Gene: Hck / 15162
• MGIID: 96052
• Length: 524
• Species: Mus musculus
• Alignment Length: 220
• Identity: 60/220 - (27%)
• Similarity: 109/220 - (49%)
• Gaps: 40/220 - (18%)

  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAE--LDGKEGLIPSNYI----EMKNHDWYY 62
            :|.:|:.|...::|||:|...:.:|  |:...|::|.  ...|||.|||||:    .::..:|::
Mouse    82 VALYDYEAIHREDLSFQKGDQMVVL--EEAGEWWKARSLATKKEGYIPSNYVARVNSLETEEWFF 144

  Fly    63 GRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSVK-----CPDGVQHFKVLRDAQSKFFLW 120
            ..|:|.|||:  |......|:|:||.||::.|.:||||:     ..|.|:|:|:.......|::.
Mouse   145 KGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYIS 209

  Fly   121 V-VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYD----FVPQESGELDFRRGDVIT 180
            . ..|:||.|||.:::.......|.:.:..:.|:.   |..::    .:|:||.:::.:.|
Mouse   210 PRSTFSSLQELVLHYKKGKDGLCQKLSVPCVSPKP---QKPWEKDAWEIPRESLQMEKKLG---- 267

  Fly   181 VTDRSDENWWNGEIGNRKGIFPATY 205
                      .|:.|.   ::.|||
Mouse   268 ----------AGQFGE---VWMATY 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	18/50 (36%)
		SH2_Grb2_like	56..149	CDD:199828	30/100 (30%)
		SH3_GRB2_like_C	156..208	CDD:212739	10/54 (19%)
Hck	NP_034537.2	SH3	80..135	CDD:473055	19/54 (35%)
		SH2_Src_HCK	138..241	CDD:198226	30/102 (29%)
		Protein Kinases, catalytic domain	252..522	CDD:473864	9/45 (20%)