Protein Alignment drk and CSK

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_004374.1
• Gene: CSK / 1445
• HGNCID: 2444
• Length: 450
• Species: Homo sapiens
• Alignment Length: 144
• Identity: 53/144 - (36%)
• Similarity: 85/144 - (59%)
• Gaps: 11/144 - (7%)

  Fly     2 EAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELD-GKEGLIPSNYIEMKN-------- 57
            |.|||::|..||:.:|.|.|..:|.|:.:..|.|||:|:.. |:||:||:||::.:.
Human    13 ECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKL 77

  Fly    58 --HDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLW 120
              ..|::|:|||..||:||.....|.||:|.|.:.|||::|.|.|...|:|::::..|.......
Human    78 SLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDE 142

  Fly   121 VVKFNSLNELVEYH 134
            .|.|.:|.:|||::
Human   143 EVYFENLMQLVEHY 156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	23/51 (45%)
		SH2_Grb2_like	56..149	CDD:199828	29/89 (33%)
		SH3_GRB2_like_C	156..208	CDD:212739
CSK	NP_004374.1	Interaction with PTPN22. /evidence=ECO:0000250|UniProtKB:P41241	9..70		24/56 (43%)
		SH3_CSK	11..67	CDD:212703	24/53 (45%)
		SH2_csk_like	78..175	CDD:198190	29/79 (37%)
		PTKc_Csk	188..443	CDD:133213