DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and Fer

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:NP_001033086.2 Gene:Fer / 14158 MGIID:105917 Length:823 Species:Mus musculus


Alignment Length:102 Identity:30/102 - (29%)
Similarity:58/102 - (56%) Gaps:5/102 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 MKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFL 119
            :..||||:|.|.|.:|::||  |.:|.||:|.|...||::.|||......:|| :::...:.:..
Mouse   456 LAEHDWYHGAIPRIEAQELL--KQQGDFLVRESHGKPGEYVLSVYSDGQRRHF-IIQFVDNLYRF 517

  Fly   120 WVVKFNSLNELVEYHRTAS--VSRSQDVKLRDMIPEE 154
            ....|:::.:|:::|....  :::...|.|.:.||::
Mouse   518 EGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKD 554

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738
SH2_Grb2_like 56..149 CDD:199828 28/94 (30%)
SH3_GRB2_like_C 156..208 CDD:212739
FerNP_001033086.2 Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250 1..300
F-BAR_Fer 5..238 CDD:153370
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..408
SH2_Fps_family 454..539 CDD:198224 26/85 (31%)
Protein Kinases, catalytic domain 567..817 CDD:473864
Blue background indicates that the domain is not in the aligned region.

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