Protein Alignment drk and CRK

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_058431.2
• Gene: CRK / 1398
• HGNCID: 2362
• Length: 304
• Species: Homo sapiens
• Alignment Length: 189
• Identity: 57/189 - (30%)
• Similarity: 93/189 - (49%)
• Gaps: 32/189 - (16%)

  Fly    51 NYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRD--- 112
            |:...:...||:||::|.:|..||..:..|.||:|.|.:||||:.|||.....|.|:.:...
Human     4 NFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPR 68

  Fly   113 --------------AQSKFFLWVVKFNSLNELVEYHR---------TASVSRSQD---VKLRDMI 151
                          :.|:..:...:|:||..|:|:::         ...||||:.   |.||.
Human    69 PPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQ-- 131

  Fly   152 PEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIG-NRKGIFPATYVTPY 209
            .|...|:||:||...:..:|.|::||::.:.|:.:|.|||.|.. .::|:.|..||..|
Human   132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	1/1 (100%)
		SH2_Grb2_like	56..149	CDD:199828	34/121 (28%)
		SH3_GRB2_like_C	156..208	CDD:212739	19/52 (37%)
CRK	NP_058431.2	SH2_CRK_like	5..122	CDD:198180	31/116 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..85		0/23 (0%)
		SH3_CRK_N	135..189	CDD:212692	19/53 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..229
		SH3_CRK_C	237..293	CDD:212693