Protein Alignment drk and Crkl

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_031790.2
• Gene: Crkl / 12929
• MGIID: 104686
• Length: 303
• Species: Mus musculus
• Alignment Length: 165
• Identity: 45/165 - (27%)
• Similarity: 81/165 - (49%)
• Gaps: 18/165 - (10%)

  Fly    60 WYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKF 124
            ||.|.:||.:|:..|..:..|.||:|.|.:.|||:.|||.....|.|:.:......:|.:...:|
Mouse    14 WYMGPVTRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEF 78

  Fly   125 NSLNELVEYHRTASVSRSQDVKLRDMIP---------------EEML--VQALYDFVPQESGELD 172
            :.|..|:|:::...:..:..::.....|               ||.|  |:.||||...::.:|.
Mouse    79 DHLPALLEFYKIHYLDTTTLIEPAPRYPSPPVGSVSAPNLPTAEENLEYVRTLYDFPGNDAEDLP 143

  Fly   173 FRRGDVITVTDRSDENWWNG-EIGNRKGIFPATYV 206
            |::|:::.:.::.:|.||:. ....|.|:.|..||
Mouse   144 FKKGELLVIIEKPEEQWWSARNKDGRVGMIPVPYV 178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738
		SH2_Grb2_like	56..149	CDD:199828	25/88 (28%)
		SH3_GRB2_like_C	156..208	CDD:212739	17/54 (31%)
Crkl	NP_031790.2	SH2_CRK_like	6..106	CDD:198180	25/91 (27%)
		SH3_CRK_N	126..180	CDD:212692	16/53 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..203
		SH3_CRK_C	237..293	CDD:212693