Protein Alignment drk and Btk

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_038510.2
• Gene: Btk / 12229
• MGIID: 88216
• Length: 659
• Species: Mus musculus
• Alignment Length: 160
• Identity: 55/160 - (34%)
• Similarity: 92/160 - (57%)
• Gaps: 25/160 - (15%)

  Fly     2 EAIAKHDFSATADDELSFRKTQILKILNMEDDSN--WYRA-ELDGKEGLIPSNYI-----EMKNH 58
            :.:|.:|:.....::|..||.:...||   ::||  |:|| :.:|:||.||||||     .::.:
Mouse   218 KVVALYDYMPMNANDLQLRKGEEYFIL---EESNLPWWRARDKNGQEGYIPSNYITEAEDSIEMY 279

  Fly    59 DWYYGRITRADAEKLLSNK-HEGAFLIRISESSPGDFSLSVKC-----PDGV-QHFKVLRDAQSK 116
            :||...:||:.||:||..: .||.|::|.| |..|.:::||..     |.|| :|:.|....||:
Mouse   280 EWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQ 343

  Fly   117 FFLWVVK--FNSLNELVEYHRTAS---VSR 141
            ::| ..|  |:::.||:.||:..|   :||
Mouse   344 YYL-AEKHLFSTIPELINYHQHNSAGLISR 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	19/53 (36%)
		SH2_Grb2_like	56..149	CDD:199828	34/98 (35%)
		SH3_GRB2_like_C	156..208	CDD:212739
Btk	NP_038510.2	PH_Btk	6..166	CDD:269944
		Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250|UniProtKB:Q06187	12..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..210
		SH3_BTK	217..271	CDD:212839	21/55 (38%)
		SH2_Tec_Btk	274..378	CDD:198260	34/101 (34%)
		PTKc_Btk_Bmx	397..652	CDD:173657
		CAV1-binding. /evidence=ECO:0000250|UniProtKB:Q06187	581..588