DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drk and hck

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	XP_005174178.1	Gene:	hck / 101885596	ZFINID:	ZDB-GENE-090313-72	Length:	499	Species:	Danio rerio

Alignment Length:	190	Identity:	60/190 - (31%)
Similarity:	106/190 - (55%)	Gaps:	21/190 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAEL--DGKEGLIPSNYI---EMKNHDWYY 62
            |||.:|:.|..:.:|.|:|...|:||  ::...|::|.:  .|:||.|||||:   .::..:|::
Zfish    57 AIALYDYEAMHEGDLGFKKGDRLRIL--QESGEWWKAVIISTGQEGFIPSNYVAKDTLETEEWFF 119

  Fly    63 GRITRADAEK--LLSNKHEGAFLIRISESSPGDFSLSVK----CPDGVQHFKVLRDAQSKFFLWV 121
            ..::|.|||:  |.|....|:|:||.||::.|.:||||:    ..|.|:|:|:.......|::..
Zfish   120 KGVSRKDAERQLLASGNKTGSFMIRDSETTKGSYSLSVRDSDHQADTVKHYKIRTLDNGGFYISP 184

  Fly   122 -VKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYD----FVPQESGELDFRRG 176
             :.||:|.:||.:::..|....|.:....:.|:.   |..::    .:|:||.:||.|.|
Zfish   185 RITFNTLQDLVSHYKKQSDGLCQSLTSPCLSPKP---QKPWEKDAWEIPRESLKLDKRLG 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	20/51 (39%)
		SH2_Grb2_like	56..149	CDD:199828	30/99 (30%)
		SH3_GRB2_like_C	156..208	CDD:212739	8/25 (32%)
hck	XP_005174178.1	SH3	58..109	CDD:302595	20/52 (38%)
		SH2	113..215	CDD:301589	30/101 (30%)
		PTKc_Hck	222..487	CDD:270658	7/20 (35%)
		Pkinase_Tyr	234..484	CDD:285015	4/8 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910