DRSC/TRiP Functional Genomics Resources

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Protein Alignment drk and abl1

DIOPT Version :10

Sequence 1:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster
Sequence 2:XP_002936228.2 Gene:abl1 / 100490771 XenbaseID:XB-GENE-6054675 Length:1128 Species:Xenopus tropicalis


Alignment Length:140 Identity:53/140 - (37%)
Similarity:82/140 - (58%) Gaps:5/140 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKN----HDWYYGR 64
            :|.:||.|:.|:.||..|.:.|::|....:..|..|:....:|.:|||||...|    |.||:|.
 Frog    94 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSPEKHSWYHGP 158

  Fly    65 ITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWV-VKFNSLN 128
            ::|..||.|||:...|:||:|.||||||..|:|::....|.|:::...:..|.::.. .:||:|.
 Frog   159 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSDSRFNTLA 223

  Fly   129 ELVEYHRTAS 138
            |||.:|.|.|
 Frog   224 ELVHHHSTVS 233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 16/48 (33%)
SH2_Grb2_like 56..149 CDD:199828 35/88 (40%)
SH3_GRB2_like_C 156..208 CDD:212739
abl1XP_002936228.2 SH3_Abl 92..145 CDD:212784 18/50 (36%)
SH2_ABL 150..243 CDD:198189 34/84 (40%)
PTKc_Abl 262..524 CDD:270645
F_actin_bind 1003..1128 CDD:471692
Blue background indicates that the domain is not in the aligned region.

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