Protein Alignment drk and btk

DIOPT Version :10

• Sequence 1: NP_476858.1
• Gene: drk / 36497
• FlyBaseID: FBgn0004638
• Length: 211
• Species: Drosophila melanogaster
• Sequence 2: NP_001123732.1
• Gene: btk / 100170477
• XenbaseID: XB-GENE-6451230
• Length: 649
• Species: Xenopus tropicalis
• Alignment Length: 147
• Identity: 43/147 - (29%)
• Similarity: 78/147 - (53%)
• Gaps: 15/147 - (10%)

  Fly     2 EAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRA-ELDGKEGLIPSNYI-----EMKNHDW 60
            :.:|.:||:.....:|...|.:...:|.....:.|.|| :.:|.||.||.||:     .::.::|
 Frog   210 KVVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNPWLRARDKNGLEGYIPGNYVTEAQDPLEIYEW 274

  Fly    61 YYGRITRADAEKLL-SNKHEGAFLIRISESSPGDFSLSVKCPDG----VQHFKVLRDAQSKFFLW 120
            |...:||:.||||| :...||.|::|.| |..|.:::||.....    ::|:.|.....::::|
 Frog   275 YSKNMTRSQAEKLLRAEDKEGGFIVRDS-SKAGKYTVSVYAKSSGEGIIRHYVVCEAPGNQYYL- 337

  Fly   121 VVK--FNSLNELVEYHR 135
            ..|  ::|:.||:.||:
 Frog   338 AEKHLYSSIPELITYHQ 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	15/51 (29%)
		SH2_Grb2_like	56..149	CDD:199828	27/87 (31%)
		SH3_GRB2_like_C	156..208	CDD:212739
btk	NP_001123732.1	PH_Btk	8..167	CDD:269944
		SH3_BTK	209..264	CDD:212839	16/53 (30%)
		SH2_Tec_Btk	267..370	CDD:198260	27/90 (30%)
		Protein Kinases, catalytic domain	388..638	CDD:473864