DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment drk and grap

DIOPT Version :9

Sequence 1:	NP_476858.1	Gene:	drk / 36497	FlyBaseID:	FBgn0004638	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_001332868.1	Gene:	grap / 100127598	XenbaseID:	XB-GENE-6258733	Length:	219	Species:	Xenopus tropicalis

Alignment Length:	218	Identity:	122/218 - (55%)
Similarity:	146/218 - (66%)	Gaps:	11/218 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRI 65
            |||.|.::|..|..|||.|:|..|:||||||||.||::|||.|:||.||.|||::|.|.||.|||
Frog     1 MEATAIYNFKTTERDELPFKKGDIIKILNMEDDQNWFKAELFGREGYIPKNYIKVKPHPWYAGRI 65

  Fly    66 TRADAEK-LLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQS--KFFLWVVKFNSL 127
            :|..||: ||.....||||||.|||||||||:||.....|||||||||.:|  |::||..|||||
Frog    66 SRQVAEEILLKRNFVGAFLIRDSESSPGDFSISVNYGHHVQHFKVLRDTESNGKYYLWEAKFNSL 130

  Fly   128 NELVEYHRTASVSRSQDVKLRDMIPEEM-----LVQALYDFVPQESGELDFRRGDVITVTDRSDE 187
            ||||:|:|..|:::..:|.|.|   ||.     .|||.|||.|.:...|.|||||:|.|.|.||.
Frog   131 NELVDYYRRHSIAKFHEVFLCD---EEQKRKIRYVQARYDFTPDQPTGLFFRRGDIIEVLDCSDP 192

  Fly   188 NWWNGEIGNRKGIFPATYVTPYH 210
            |||.|.|....|:||..||.|.|
Frog   193 NWWRGRISGVTGMFPQNYVHPIH 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
drk	NP_476858.1	SH3_GRB2_like_N	2..53	CDD:212738	30/50 (60%)
		SH2_Grb2_like	56..149	CDD:199828	56/95 (59%)
		SH3_GRB2_like_C	156..208	CDD:212739	28/51 (55%)
grap	NP_001332868.1	SH3_GRAP_N	2..55	CDD:212881	32/52 (62%)
		SH2_Grb2_like	56..152	CDD:199828	56/95 (59%)
		SH3_GRAP_C	161..213	CDD:212884	28/51 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46063
OrthoDB	1	1.010	-	-		D1091250at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.030