DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cid and CENPA

DIOPT Version :9

Sequence 1:	NP_523730.2	Gene:	cid / 36495	FlyBaseID:	FBgn0040477	Length:	225	Species:	Drosophila melanogaster
Sequence 2:	NP_001800.1	Gene:	CENPA / 1058	HGNCID:	1851	Length:	140	Species:	Homo sapiens

Alignment Length:	132	Identity:	48/132 - (36%)
Similarity:	67/132 - (50%)	Gaps:	7/132 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 RRMTVQQESKTRAAGPVAAQNQTRRRKA--ANPMSRAKRMD---REIRRLQHHPGTLIPKLPFSR 155
            ||....:..:.|:..|......:||..:  |:....::|..   :|||:||.....||.||||||
Human     5 RRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHLLIRKLPFSR 69

  Fly   156 LVREFIVKYSDDEPLRVTEGALLAMQESCEMYLTQRLADSYMLTKHRNRVTLEVRDMALMAYICD 220
            |.||..||::..........||||:||:.|.:|.....|:|:||.|..||||..:|:.|...|
Human    70 LAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVTLFPKDVQLARRI-- 132

  Fly   221 RG 222
            ||
Human   133 RG 134

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cid	NP_523730.2	H4	135..219	CDD:419976	37/83 (45%)
CENPA	NP_001800.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		8/40 (20%)
		H3	34..137	CDD:128705	42/103 (41%)
		Important for flexibility of DNA ends that protrude from nucleosomes. /evidence=ECO:0000269\|PubMed:27499292	39..54		4/14 (29%)
		CATD. /evidence=ECO:0000269\|PubMed:15282608, ECO:0000269\|PubMed:7962047	75..116		14/40 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1745
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11426
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910