DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbc and CG8414

DIOPT Version :9

Sequence 1:	NP_610876.1	Gene:	cbc / 36494	FlyBaseID:	FBgn0033842	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_611084.2	Gene:	CG8414 / 36774	FlyBaseID:	FBgn0034073	Length:	995	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	97/464 - (20%)
Similarity:	168/464 - (36%)	Gaps:	138/464 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDQGKDYTLESDSELRFEIE-QKDAKVLVSLVSGFAELFGT----------ELVKKKQYEFGVGA 56
            |:..|::|......::...: |.:|.||:...:...:|..|          .||......||...
  Fly   538 EELNKNFTRAQLDRIKTSFQRQTNAIVLLHRNTSAQQLVDTFGKHMAQNVFPLVNSSNRPFGQSE 602

  Fly    57 KVAIFTYQGCVLHVSGKMDVCYISKETPMVQYVNCHAALEQFRMEAEEKDRYGPVAMVVGPMDVG 121
                 |...|::..|.:      |:...:.|..|      :.:|.|..:      .:|.|...||
  Fly   603 -----TLLHCLIQSSDQ------SRTLQVPQVWN------KLQMHATSR------IIVAGGKGVG 644

  Fly   122 KSTLCRILLNYAVRVGRRP--LYADLDVGQGSIAISGSVATILIERPANVEEGFAKTAPLVYH-- 182
            ||:|.|.|:|.  .:|:.|  |..|||:||..|.:..:::..:|:.|. :..||      :|:
  Fly   645 KSSLLRYLINR--NLGQFPSMLLIDLDIGQPEIFVPQTISCTVIDEPL-LGPGF------LYNRQ 700

  Fly   183 ------FGHKSPSGNSVLYNAVVSKMAEVTLQSLNSNKRTKSSGIIINTCGWVKGSG---YAHLL 238
                  .||.    |.||.....::.....:|::.::.:..:...:|||.|:.||.|   .|.|:
  Fly   701 PEHAIVVGHT----NIVLCAEQYARAVIQLVQNIQNDAKYSNIPWLINTMGYNKGFGIELMALLV 761

  Fly   239 HAAKAYGACAI----------FVLDQERL-------YNE---LLRDVPKG-----VHVVLLPKSG 278
            ...:......|          .|||:..|       |:.   .:.::||.     :..|...:.|
  Fly   762 DRIRPTDLVQIASPIPINNFDSVLDRNSLSQIKPIIYSAEEFKINEIPKYTLHKLISAVPAREKG 826

  Fly   279 GVVERSKELRHEARDQRIKEYFYGNTRAPFYPFSFEVKFQDLRLYKIGAPPLPDSCMPIGMKAED 343
            .....:|::|:.....|:.....||.::                       |.| |.|:|:..|.
  Fly   827 TWSLSAKDMRYSNLLARLSSCLTGNAKS-----------------------LTD-CQPLGVSLES 867

  Fly   344 NKTKVVAVTPTPALIHHVLALSFAESVEDDVIG--TNVAGFC--------C-----VTEVDMERQ 393
            .|            |.|..:.::  |.|:.:.|  .||...|        |     |..:|.||:
  Fly   868 LK------------ILHPTSKNY--SREELIRGMEANVVYLCHHGAGLPQCLGIGVVRAIDYERK 918

  Fly   394 AVMLLSPQP 402
            .:.|:...|
  Fly   919 ELYLVPAMP 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbc	NP_610876.1	CLP1_N	9..102	CDD:293181	18/103 (17%)
		CLP1	11..412	CDD:227910	94/456 (21%)
		CLP1_P	116..301	CDD:293183	51/222 (23%)
		Clp1	309..420	CDD:284274	22/109 (20%)
CG8414	NP_611084.2	HC2	41..>163	CDD:284736
		RNA_pol_3_Rpc31	<255..333	CDD:288542
		P-loop_NTPase	639..824	CDD:304359	47/197 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12755
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940