DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cbc and Clp1

DIOPT Version :9

Sequence 1:	NP_610876.1	Gene:	cbc / 36494	FlyBaseID:	FBgn0033842	Length:	423	Species:	Drosophila melanogaster
Sequence 2:	NP_001009599.1	Gene:	Clp1 / 311166	RGDID:	1307679	Length:	425	Species:	Rattus norvegicus

Alignment Length:	426	Identity:	237/426 - (55%)
Similarity:	313/426 - (73%)	Gaps:	9/426 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEDQGKD------YTLESDSELRFEIEQKDAKVLVSLVSGFAELFGTELVKKKQYEFGVGAKVA 59
            |||:...|      :.||.::|||||:|...: |.:.|::|.||:|||||.:.|::.|..|||||
  Rat     1 MSEESNDDKKPTTKFELERETELRFEVEASQS-VQLELLAGMAEIFGTELTRNKKFTFDAGAKVA 64

  Fly    60 IFTYQGCVLHVSGKMDVCYISKETPMVQYVNCHAALEQFRMEAEEKDRYGPVAMVVGPMDVGKST 124
            :||:.||.|.:||:.:|.|:||:|||:.|:|.|.||||.|.:||:::..||..|||||.||||||
  Rat    65 VFTWHGCSLQLSGRTEVAYVSKDTPMLLYLNTHTALEQMRRQAEKEEERGPRVMVVGPTDVGKST 129

  Fly   125 LCRILLNYAVRVGRRPLYADLDVGQGSIAISGSVATILIERPANVEEGFAKTAPLVYHFGHKSPS 189
            :||:|||||||:||||.|.:|||||||::|.|::..:.|||||:|||||:..||||||||..:|.
  Rat   130 VCRLLLNYAVRLGRRPTYVELDVGQGSVSIPGTMGALYIERPADVEEGFSIQAPLVYHFGSTTPG 194

  Fly   190 GNSVLYNAVVSKMAEVTLQSLNSNKRTKSSGIIINTCGWVKGSGYAHLLHAAKAYGACAIFVLDQ 254
            .|..|||.:.|::|:|..|....|:|...||.:|||||||||.||..|:|||.|:....:.||||
  Rat   195 TNIKLYNKITSRLADVFNQRCEVNRRASVSGCVINTCGWVKGYGYQALVHAASAFEVDVVVVLDQ 259

  Fly   255 ERLYNELLRDVPKGVHVVLLPKSGGVVERSKELRHEARDQRIKEYFYGNTRAPFYPFSFEVKFQD 319
            |||||||.||:|..|..||||||||||||||:.|.|.||:||:||||| .|..|||.:|.|||.|
  Rat   260 ERLYNELKRDLPHFVRTVLLPKSGGVVERSKDFRRECRDERIREYFYG-FRGCFYPHAFNVKFSD 323

  Fly   320 LRLYKIGAPPLPDSCMPIGMKAEDNKTKVVAVTPTPALIHHVLALSFAESVEDDVIGTNVAGFCC 384
            :::||:|||.:||||:|:||..|||:.|:|.|||...::||:|::|.||..|:::..|:||||..
  Rat   324 VKIYKVGAPTIPDSCLPLGMSQEDNQLKLVPVTPGRDMVHHLLSVSTAEGTEENLSETSVAGFIV 388

  Fly   385 VTEVDMERQAVMLLSPQPRPLPPNALLLWSELQFMD 420
            ||.||:|.|...:|||.|||||.|.||: .:::|||
  Rat   389 VTSVDVEHQVFTVLSPAPRPLPKNFLLI-MDIRFMD 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbc	NP_610876.1	CLP1_N	9..102	CDD:293181	47/92 (51%)
		CLP1	11..412	CDD:227910	229/400 (57%)
		CLP1_P	116..301	CDD:293183	115/184 (63%)
		Clp1	309..420	CDD:284274	57/110 (52%)
Clp1	NP_001009599.1	CLP1	14..423	CDD:227910	231/411 (56%)
Clp1	NP_001009599.1	CLP1_P	121..306	CDD:406878	115/184 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353431
Domainoid	1	1.000	247	1.000	Domainoid score	I2096
eggNOG	1	0.900	-	-		E1_COG5623
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4975
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1400
OMA	1	1.010	-	-		QHG53868
OrthoDB	1	1.010	-	-		D370259at33208
OrthoFinder	1	1.000	-	-		FOG0003461
OrthoInspector	1	1.000	-	-		oto95613
orthoMCL	1	0.900	-	-		OOG6_101503
Panther	1	1.100	-	-	LDO	PTHR12755
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3913
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770