DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cbs and Golga1

DIOPT Version :9

Sequence 1:	NP_610875.1	Gene:	cbs / 36492	FlyBaseID:	FBgn0086757	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_036018584.1	Gene:	Golga1 / 76899	MGIID:	1924149	Length:	784	Species:	Mus musculus

Alignment Length:	789	Identity:	211/789 - (26%)
Similarity:	344/789 - (43%)	Gaps:	228/789 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFATLKNKIKEETGDDVVQSANQRYPGNNNNNYRLRSRR--VSINSNSADDVGGGGFYNE---SE 60
            |||.||.||.|||      :..|| ||......|..|:.  .|:.::|.||....|..:.   |.
Mouse     1 MFAKLKKKIAEET------AVAQR-PGGTTRIPRSVSKESVASMGADSGDDFASDGSSSREDLSS 58

  Fly    61 QLCELRSQCNELTTKLSTVTQGLQQLQEEKTRVDKTNEILLE-----SVRVAQTQKDIY------ 114
            ||.....|..:|..:||...:.::.||:.|.::    ||.||     |:|..|.|.:.:
Mouse    59 QLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKL----EIALEKHQDSSMRKFQEQNETFQASRAK 119

  Fly   115 ----------CEEQEKIQNLQQIEIDK---------LKN--LLSFREQESVDR------------ 146
                      .::||..:.::|:|.||         :||  |..|::::.:|.
Mouse   120 MAEGLALALARKDQEWSEKMEQLEKDKRFLTSQLQEVKNQSLSLFQKRDEIDELEGFQQQEISKV 184

  Fly   147 ----------MGLMRQQ----TQQIESLSEEL-----------ERLRPIE---SVAEDLRDEL-- 181
                      :|.|.|:    |:::....|||           |||..::   |..|:.||.|
Mouse   185 KHMLLKKEECLGKMEQELDARTRELNRTQEELVTSNQLSSDLNERLEELQRHCSTLEEQRDHLTA 249

  Fly   182 ----------------EQLRHSTQQEKNLLTTTLAAVQEENR---HLKKRMKIVEESRLESLGKL 227
                            ::|:...||....|....|..||:.:   ||:::: |..|.|||.  .|
Mouse   250 SKAGAEHKIVVLEQKEQELQAIIQQHSIDLQKVTAETQEKEKVITHLQEKV-IFLEKRLEQ--NL 311

  Fly   228 NSEQQVQALIREHKLLEQHLEEAHLQLSDIKGSWSGQNLALETQVSRL--SKQVAEE-TTEKRKA 289
            :.|..||.|::|..:.||:||:...||...:.|.:.....|||:|..|  |.|.||| .::.|..
Mouse   312 SGEDHVQELLKEKTVAEQNLEDTRQQLLAARNSHTKALYLLETRVKDLERSLQAAEEQLSQSRNV 376

  Fly   290 LKSRDDAIE-----------SRKQVSFELEKAKDEIKQRDDKVKLLEE--------------EID 329
            :..::..|:           |::||....:..::.|...:.:::.||:              ::.
Mouse   377 VADQEAQIQKLITTNQENSLSQQQVLALEQHCRERIHALEAQIEALEQTRVADQIASEQGMLQLQ 441

  Fly   330 ELSVALKECREENEQQVLFERNKSQNLETEVKDLKTRLTAADDRFSEYSSNAEQVAQKLRVQVTE 394
            :.:|||||.|.|.|..:       |:.:.|:|.||       |.:|:....:..:||.|. :|.:
Mouse   442 QENVALKESRNECEHSL-------QHHQLELKKLK-------DEWSQREIVSVAMAQALE-EVRK 491

  Fly   395 KQEQLDETIMQLEIEREEKMTAILRNAE-IAQSEDILRQQLRLERSEASDLQERNNQLVRDISEA 458
            ::|:..:...:|....|||..::....| :.|.|..|||   ||:..:|.|.:. ::|.|:: ||
Mouse   492 QREEFQQQATELTAIIEEKNQSLCEKDEALLQKEQELRQ---LEKGHSSALLQM-HKLQREL-EA 551

  Fly   459 RQTLQQ---------------------VSSTAQDNAD-------------------KLTEFERVQ 483
            .:|.:.                     |.|.|..|::                   |..:.|:..
Mouse   552 LKTCKAQEAMPATTGEDCLPLQGQEPLVISKAMQNSEYELPAAEGTPNGEVGASDLKQLQKEKQD 616

  Fly   484 LE--IIEKNKTIKTLNQRLIDLKKTVQKELRSAQISTDSE----------SHPTTTPGHRISSSS 536
            ||  :|||||.:|.:.||:::||||:||||:   |..|||          ..|...|....::..
Mouse   617 LEQQLIEKNKIMKQMQQRMLELKKTLQKELK---IRPDSELFEVREKTGPEIPNMAPSVTNNTDL 678

  Fly   537 LEAFSTGDKGNCVIMDEVNFQYLKHVIVKFLTSREVEARHLVRAVSTLLQLTTEEEKLLHDTLNW 601
            .:|            .|:||:|||||::||::.||.||.||::|||.||..:.|||.:|.:||.:
Mouse   679 TDA------------REINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENMLKETLEY 731

  Fly   602 KMSWFGMKP 610
            |:|::|:.|
Mouse   732 KVSFWGLLP 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbs	NP_610875.1	AmyAc_family	<276..>372	CDD:298606	26/121 (21%)
cbs	NP_610875.1	Grip	553..598	CDD:197860	25/44 (57%)
Golga1	XP_036018584.1	SMC_prok_B	<151..504	CDD:274008	85/370 (23%)
		pneumo_PspA	441..>671	CDD:411490	68/252 (27%)
		Grip	683..728	CDD:197860	25/44 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10917
eggNOG	1	0.900	-	-		E1_KOG0992
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	173	1.000	Inparanoid score	I4070
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47149
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007916
OrthoInspector	1	1.000	-	-		oto93883
orthoMCL	1	0.900	-	-		OOG6_108912
Panther	1	1.100	-	-	LDO	PTHR23157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5125
SonicParanoid	1	1.000	-	-		X5869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860