DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cbs and CCDC186

DIOPT Version :9

Sequence 1:	NP_610875.1	Gene:	cbs / 36492	FlyBaseID:	FBgn0086757	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001308758.1	Gene:	CCDC186 / 55088	HGNCID:	24349	Length:	898	Species:	Homo sapiens

Alignment Length:	771	Identity:	158/771 - (20%)
Similarity:	298/771 - (38%)	Gaps:	237/771 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PGNNNNNYRLRSRRVSINSNSADDVGGG----------------------GFY-------NESEQ 61
            |..:||       |:....|...|.|||                      |.:       ||:||
Human    56 PNEHNN-------RIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQ 113

  Fly    62 -----LCELRS-----QCNELT---------------TKLSTVTQGLQQLQEEKTRVDKT----- 96
                 |.||||     ..||.|               :|:.:|:.....|:|.::.:..|
Human   114 KVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEH 178

  Fly    97 ------NE-----ILLESVRVAQTQKDIYCEEQEKIQNL-------QQI------EIDKLKNLLS 137
                  |:     :|.|     :..:|.|.:::..|:.|       |::      |.|.|:..|.
Human   179 RVPNGMNKGEHALVLFE-----KCVQDKYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELK 238

  Fly   138 FREQESVDRMGLMRQQTQQIESLSEELERLRPIESVAEDL--RDELEQLR--------------H 186
            .|.:.....|..::|...:||.|::|::..|. :.:|:|:  ::.::||.              .
Human   239 KRTETEKQHMNTIKQLESRIEELNKEVKASRD-QLIAQDVTAKNAVQQLHKEMAQRMEQANKKCE 302

  Fly   187 STQQEKNLLTTTLAAVQEENRHLKKRMKIVEE-------------SRLESL----GKLN-----S 229
            ..:|||..:.......::|:..|:|..:.:|:             ::::.|    |:|:     .
Human   303 EARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETK 367

  Fly   230 EQQVQALIREHKLLEQHLEEAHLQLSDIKGSWSGQNLALETQVSRLSKQVAEETTEKRKALKSRD 294
            |.:...||||...|::.: .:|:    ||..|:...|..|....:.:|...:|||.|....|...
Human   368 EGETTRLIREIDKLKEDI-NSHV----IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEA 427

  Fly   295 DAIESRKQVSFELEKAKDEIKQRDDKVKL----------LEEEIDELSVALKECREENEQQVLFE 349
            |.|....|...:..:..:|||..:...||          ::|:.|:|.:...:.:|..:.:..|:
Human   428 DQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFK 492

  Fly   350 R--NKSQNLETEVKDLKTRLTAADDRFSEYS-----------------SNAEQVAQKLR------ 389
            .  ::.:.|.|:||.|:......:|..|:|.                 ..|:|:.::|:
Human   493 EGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEI 557

  Fly   390 VQVTEKQEQLDETI--MQLEIE----RE-------EKMTAILRNAEIAQSEDILRQQLRLERSEA 441
            ..:.|:.|.|:..|  :|.:||    ||       |::|:  :||::....:.|:.|........
Human   558 ENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTS--KNAQLQSESNSLQSQFDKVSCSE 620

  Fly   442 SDLQERNNQLVRDISEARQT-LQQVSSTAQDNADKLTEFERVQLEIIEKNKTIKTLNQRLIDLK- 504
            |.||.:..|:       :|| :...|...::...:..|.:.:|.|:..:...:|.|:.::.:||
Human   621 SQLQSQCEQM-------KQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKD 678

  Fly   505 -------------KTVQKELRSA-----QISTDSESHPTTTPGHRISSS-SLEAFSTGD------ 544
                         |.:.|:|:.|     |:.:.|.....::.|.|.||| ||.|.|:.:
Human   679 ELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVSSMGSRSSSSGSLNARSSAEDRSPEN 743

  Fly   545 KGNCVIMDEVNFQYLKH--VIVKFLTSREVEAR----------HLVRAVSTLLQLT 588
            .|:.|.:|  ||..:..  :|.:.:..::..||          |:.:.|..:.:.|
Human   744 TGSSVAVD--NFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKT 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbs	NP_610875.1	AmyAc_family	<276..>372	CDD:298606	24/107 (22%)
cbs	NP_610875.1	Grip	553..598	CDD:197860	8/48 (17%)
CCDC186	NP_001308758.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..95		5/26 (19%)
		SMC_N	208..>594	CDD:330553	80/391 (20%)
		SMC_N	454..>737	CDD:330553	62/291 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..749		12/46 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0992
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900