DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cbs and golga1

DIOPT Version :9

Sequence 1:	NP_610875.1	Gene:	cbs / 36492	FlyBaseID:	FBgn0086757	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_957132.2	Gene:	golga1 / 393811	ZFINID:	ZDB-GENE-040426-1237	Length:	862	Species:	Danio rerio

Alignment Length:	872	Identity:	220/872 - (25%)
Similarity:	358/872 - (41%)	Gaps:	287/872 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFATLKNKIKEETGDDVVQSANQRYPGNNNNNYRLRSRR--VSINSNSADDVGGGGFYNE---SE 60
            |||.||.|:.||.   .....:.|.|       |..|:.  .|:.::|.||....|..:.   |.
Zfish     1 MFAKLKKKLAEEA---ATAPRSGRIP-------RSMSKESITSVGADSGDDFASDGSSSRDDFSS 55

  Fly    61 QLCELRSQCNELTTKLSTVTQGLQQLQEEKTRVD---------------------KTNEI-LLES 103
            |:.....|..:|..|||...:.|:.:|:.|.:::                     :||.. :.|:
Zfish    56 QIQRRNDQIRKLEAKLSDYAEQLRLMQKTKEKLEIALEKYQDSSMRKLQDQNESFQTNRAKMAEA 120

  Fly   104 VRVAQTQKD------IYCEEQEK--------------------------IQNLQQIEIDKLKNLL 136
            :.:|..:||      :...||||                          ::..||.|:.|:|::|
Zfish   121 MSLALEKKDQEWMEKLASLEQEKLSLTSRLDEMTEQSLSLFQKRDDLDELEGFQQQELAKVKHML 185

  Fly   137 SFREQE---------------SVDRMGL---------------------MRQQTQQIESLSE--- 162
            ..||::               :..|:.|                     .:.|.|:.|.|||
Zfish   186 LRREEQLNQREKELKLRGEELNTARLTLGKTQDKLYELGEEHEEICRTNSQLQAQRDELLSEKEE 250

  Fly   163 -------------ELERLRPIESVAED-----------------LRDELEQLRHSTQQEKNLLTT 197
                         ||::|  |:.|:||                 |:.|..:|:...:|.||.:..
Zfish   251 AERRVVDLERREQELQQL--IQQVSEDFQKAQSNAEALEKSMEHLQSEHNKLKLQHEQHKNKVAV 313

  Fly   198 T-------LAAVQEENRHLKKRMKIVEESRLESLGKLNSEQQVQALIREHKLLEQHLEEAHLQLS 255
            |       |:.:||:...|::|::          ...:.::.:|.|::|...|||.||||..:|.
Zfish   314 TEEERERILSDLQEKAASLERRLE----------ANFSQDEHLQELLKEKSSLEQRLEEARGELL 368

  Fly   256 DIKGSWSGQNLALETQVSRLSKQVAEETTEKRKALKSRDDAIES-RKQVSFELEKAKDEIKQRDD 319
            ..|.|.:....:||.||||.:..:.:..|    .:|.:||:.:: |::...::...:..:....:
Zfish   369 QEKTSHTTAVSSLEAQVSRQNASIIDLQT----LVKHKDDSSKAYRERTDAQISDLEQRLADCAE 429

  Fly   320 KVKLLEEEI-------DELSVALKECREENEQQVLFER----NKSQNLETEV----KDLKTRLTA 369
            |:|.|::::       |:|.:...|.||..:|||..:|    .|:..||.|:    :|.:|....
Zfish   430 KMKSLQQQLKDSQMHTDKLQMEWSEERERLQQQVSTQRQRGLEKTARLEEELLAVQRDRETEANK 494

  Fly   370 ADDRF--------------SEYSSNAEQVAQKL---RVQVTEKQ-------EQLDETIMQLEIER 410
            ..|..              .|..|..|.:..:|   |.:::.:|       :.|:||..|.|..:
Zfish   495 YQDNLRLLEEEKNSLLRSKGETDSTVESLTAELEQSRAEMSSRQTVSVEIAKALEETRKQREELQ 559

  Fly   411 EE--KMTAILRNA--EIAQ-SEDI---------LRQQLRLERSEASDLQ---------------E 446
            ::  |||..|..|  |::: |:|:         |:::|:..||..|.||               |
Zfish   560 QQVSKMTESLVKAEQEVSRLSQDLGVKEEEVNALKEELQAARSSLSSLQAECESRRLEAEEKERE 624

  Fly   447 RNNQLVRDISEARQTLQQVSS---------------TAQDNADK-------------LTEFERV- 482
            .|:||.....|..:..||:||               ||..:||:             |.:.::|
Zfish   625 HNSQLTSLQQEVLRQTQQLSSYQSRVSDLESEVLSLTAHSHADECEGEQNGTVTVSDLDQLQKVN 689

  Fly   483 ---QLEIIEKNKTIKTLNQRLIDLKKTVQKEL--------------------RSAQISTDSESHP 524
               :.::.|||||||.|.|||.:||:|:||||                    |||:.:......|
Zfish   690 KDLEQQLAEKNKTIKQLQQRLAELKRTLQKELKLKPDPDSEMKERLQDGRQERSAEKTVLETPMP 754

  Fly   525 TTTPGHRISSSSLEAFSTGD---KGNCVIMD--EVNFQYLKHVIVKFLTSREVEARHLVRAVSTL 584
            |..|...:..|......|.:   ..:..|.|  |:||:|||||::||::|||.||..|:||||.|
Zfish   755 TAAPSPALGLSQTPGPITPNTTVTNSSDITDTREINFEYLKHVVLKFMSSREAEAFQLIRAVSVL 819

  Fly   585 LQLTTEEEKLLHDTLNWKMSWFGMKPT 611
            |..:.|||.:|..||.:||||||.||:
Zfish   820 LHFSKEEEDMLKQTLEYKMSWFGSKPS 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbs	NP_610875.1	AmyAc_family	<276..>372	CDD:298606	23/111 (21%)
cbs	NP_610875.1	Grip	553..598	CDD:197860	26/44 (59%)
golga1	NP_957132.2	Filament	416..647	CDD:278467	54/230 (23%)
		TTKRSYEDQ	<453..643	CDD:287216	46/189 (24%)
		MreC	<679..>732	CDD:302802	20/52 (38%)
		GRIP	789..830	CDD:279767	24/40 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6475
eggNOG	1	0.900	-	-		E1_KOG0992
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	167	1.000	Inparanoid score	I4150
OMA	1	1.010	-	-		QHG47149
OrthoDB	1	1.010	-	-		D414719at33208
OrthoFinder	1	1.000	-	-		FOG0007916
OrthoInspector	1	1.000	-	-		oto40593
orthoMCL	1	0.900	-	-		OOG6_108912
Panther	1	1.100	-	-	LDO	PTHR23157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5125
SonicParanoid	1	1.000	-	-		X5869
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870