DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cbs and GOLGA1

DIOPT Version :9

Sequence 1:NP_610875.1 Gene:cbs / 36492 FlyBaseID:FBgn0086757 Length:611 Species:Drosophila melanogaster
Sequence 2:NP_002068.2 Gene:GOLGA1 / 2800 HGNCID:4424 Length:767 Species:Homo sapiens


Alignment Length:796 Identity:209/796 - (26%)
Similarity:347/796 - (43%) Gaps:233/796 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFATLKNKIKEETGDDVVQSANQRYPGNNNNNYRLRSRR--VSINSNSADDVGGGGFYNE---SE 60
            |||.||.||.|||      :..|| ||......|..|:.  .|:.::|.||....|..:.   |.
Human     1 MFAKLKKKIAEET------AVAQR-PGGATRIPRSVSKESVASMGADSGDDFASDGSSSREDLSS 58

  Fly    61 QLCELRSQCNELTTKLSTVTQGLQQLQEEKTRVDKTNEILLE-----SVRVAQTQKDIY------ 114
            ||.....|..:|..:||...:.::.||:.|.::    ||.||     |:|..|.|.:.:      
Human    59 QLLRRNEQIRKLEARLSDYAEQVRNLQKIKEKL----EIALEKHQDSSMRKFQEQNETFQANRAK 119

  Fly   115 -----------------------------------------------CEEQEKIQNLQQIEIDKL 132
                                                           .:|.::::..||.|:.|:
Human   120 MAEGLALALARKDQEWSEKMDQLEKEKNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKI 184

  Fly   133 KNLLSFREQESVDRM---------GLMRQQTQQIES------LSEELERLRPIESVAEDLRDE-- 180
            |::| .:::||:.:|         .|.|.|.:.:.|      ||::||.|:...|..|:.||.  
Human   185 KHML-LKKEESLGKMEQELEARTRELSRTQEELMNSNQMSSDLSQKLEELQRHYSTLEEQRDHVI 248

  Fly   181 ------------LEQLRHSTQQEKNLLTTTLAAVQEENR-------HLKKRMKIVEESRLESLGK 226
                        |||.....|.....|:..|..|..|.:       ||::::..:|: |||.  .
Human   249 ASKTGAESKITALEQKEQELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEK-RLEQ--N 310

  Fly   227 LNSEQQVQALIREHKLLEQHLEEAHLQLSDIKGSWSGQNLALETQVSRLSK--QVAEETTEKRKA 289
            |:.|:.:|.|::|..|.||:||:...||...:.|.:.....|||:|..|.:  |.:||..::.|.
Human   311 LSGEEHLQELLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKG 375

  Fly   290 LKS--------------------------------RDDAIESRKQVSFELEKAKDEIKQRDDKVK 322
            :.:                                |..|:|: :.|:.|..:|.|: ...:..::
Human   376 IVAAQETQIQELAAANQESSHVQQQALALEQQFLERTQALEA-QIVALERTRAADQ-TTAEQGMR 438

  Fly   323 LLEEEIDELSVALKECREENEQQVLFERNKSQNLETEVKDLKTRLTAAD---------------- 371
            .||:|    :.||||||.|.|:.:       ||.:.|:|.||...:..:                
Human   439 QLEQE----NAALKECRNEYERSL-------QNHQFELKKLKEEWSQREIVSVAMAQALEEVRKQ 492

  Fly   372 -DRFSEYSSNAEQVAQKLRVQVTEKQE---QLDETIMQLE------------IEREEKMTAILRN 420
             :.|.:.::|...:..:....:.||.|   |.::.|:|||            ::.|.:....|:.
Human   493 REEFQQQAANLTAIIDEKEQNLREKTEVLLQKEQEILQLERGHNSALLQIHQLQAELEALRTLKA 557

  Fly   421 AE---IAQSEDILRQQLRLERSEASDLQERN--NQLVRD----ISEARQT---------LQQVSS 467
            .|   :|:.||:||.:..|: :||..:.|.:  ::.::|    :..|.:|         |.|:..
Human   558 EEAAVVAEQEDLLRLRGPLQ-AEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDLTQLQK 621

  Fly   468 TAQDNADKLTEFERVQLEIIEKNKTIKTLNQRLIDLKKTVQKELRSAQISTDSESHPT-TTPGHR 531
            ..||          ::.:::|||||||.:.||:::|:||:||||:   |..|:|.... ..||..
Human   622 EKQD----------LEQQLLEKNKTIKQMQQRMLELRKTLQKELK---IRPDNELFEVREKPGPE 673

  Fly   532 ISSSSLEAFSTGDKGNCVIMD--EVNFQYLKHVIVKFLTSREVEARHLVRAVSTLLQLTTEEEKL 594
            :::.:....:..|     :.|  |:||:|||||::||::.||.||.||::|||.||..:.|||.:
Human   674 MANMAPSVTNNTD-----LTDAREINFEYLKHVVLKFMSCRESEAFHLIKAVSVLLNFSQEEENM 733

  Fly   595 LHDTLNWKMSWFGMKP 610
            |.:||.:||||||.||
Human   734 LKETLEYKMSWFGSKP 749

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cbsNP_610875.1 AmyAc_family <276..>372 CDD:298606 28/146 (19%)
Grip 553..598 CDD:197860 25/44 (57%)
GOLGA1NP_002068.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..58 12/51 (24%)
SMC_prok_B <121..447 CDD:274008 69/335 (21%)
Smc <249..649 CDD:224117 99/426 (23%)
Grip 692..737 CDD:197860 25/44 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..767 2/2 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 105 1.000 Domainoid score I6686
eggNOG 1 0.900 - - E1_KOG0992
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 173 1.000 Inparanoid score I4093
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47149
OrthoDB 1 1.010 - - D414719at33208
OrthoFinder 1 1.000 - - FOG0007916
OrthoInspector 1 1.000 - - oto90301
orthoMCL 1 0.900 - - OOG6_108912
Panther 1 1.100 - - LDO PTHR23157
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5125
SonicParanoid 1 1.000 - - X5869
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

Return to query results.
Submit another query.