Protein Alignment Golgin97 and Ccdc186

DIOPT Version :10

• Sequence 1: NP_610875.1
• Gene: Golgin97 / 36492
• FlyBaseID: FBgn0086757
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_739563.1
• Gene: Ccdc186 / 213993
• MGIID: 2445022
• Length: 917
• Species: Mus musculus
• Alignment Length: 714
• Identity: 147/714 - (20%)
• Similarity: 279/714 - (39%)
• Gaps: 197/714 - (27%)

  Fly    12 ETGDDVVQSANQRYPGNNNNNYRLRSRRVSINSNSADDVGGGGFYNESEQLCELRSQCNE----- 71
            |||.:::...:.|.....|.:    ..::.:..:...|.|.|      |..|.....|.|
Mouse    57 ETGAELLSLDSDRILCQTNEH----CSQIEVQESHIPDCGSG------ENSCANTDTCPEDSGQI 111

  Fly    72 -------LTTKLS-------TVTQGLQQLQEE--------KTR------VDKTNEILLESVRVAQ 108
                   .|.::|       ||||.|.:|:..        ||.      .|.|.:::.| ::...
Mouse   112 DDFPGGDFTEQVSKTKEPEQTVTQILAELKSSAPAEAANPKTASASLYDTDCTRKLISE-MKTVS 175

  Fly   109 TQKDIYCEEQEKIQNLQQIEIDKLKNLLSFREQ------ESVDRMGLMRQQT--QQIESLSEELE 165
            ...|:..|.:.::.:.:..|..::.|.|:..||      :.|....|.::.|  |.|:......|
Mouse   176 ASDDLLGEIESELLSAEFAEGHQVPNGLNKGEQALALFEKCVHSRYLQQELTVKQLIKENKNHQE 240

  Fly   166 RLRPIESVAEDLRDELEQLRHSTQQEKNLLTTTLAAVQEENRHLK--KRMKIVEESRLESLGKLN 228
            .:..|.|..:.||:||.:...:.:|..|.:......::|.|:.:|  |...:.::...:     |
Mouse   241 LILNICSEKDSLREELRKRTETEKQHMNTIKQLELRIEELNKEIKASKDQLVAQDVTAK-----N 300

  Fly   229 SEQQVQALIREHKLLEQHLEEAHLQLSDIKGSWSGQNLALETQVSRLSKQVAEETTEKR----KA 289
            :.||:      ||.:.|.:::|                         :|:..|...||.    |.
Mouse   301 AIQQI------HKEMAQRMDQA-------------------------NKKCEEARQEKEAMVMKY 334

  Fly   290 LKSRDDAIESRKQ----------VSFELEKAKDEIKQRDDKVKLLEE-------EIDELSVALKE 337
            ::...:|::.||:          .|.||||..::|||...:...|::       |...|...:::
Mouse   335 VRGEKEALDLRKEKETLERKLRDASKELEKNTNKIKQLSQEKGRLQQLYESKEGETTRLIREIEK 399

  Fly   338 CREENEQQVLFERNKSQNLETEV---KDLKTRLTAADDRFSEYSSNAEQVAQ------------- 386
            .:||...||:..:.....|:.|:   |:.|.:|.....:.::....|||:.|
Mouse   400 LKEEMNSQVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAEQIRQNCQDMIKTYQESE 464

  Fly   387 ---------KLRVQVTEKQEQLDETIMQLEIEREEKMTAILRNAEIAQSEDILR------QQLRL 436
                     ||||...|.::|:.|...|||          :.:|:|.:.||:.|      .:||.
Mouse   465 EIKSNELDAKLRVTKGELEKQMQEKSDQLE----------MHHAKIKELEDLKRTFKEGMDELRT 519

  Fly   437 ERSEASDLQERNNQLVRDISEARQTLQQVSSTAQDNAD--KLTEFERVQL-----EIIEKNKTIK 494
            .|::|..|::...:...::|:.|:.:.:..|..|:..|  |:|:....||     ||....:.::
Mouse   520 LRTKAKCLEDERLRTEDELSKYREIINRQKSEIQNLLDKVKITDQLHEQLQSGKQEIEHLKEEME 584

  Fly   495 TLNQRLIDLKKTV------QKEL---------RSAQISTDSESHPTTTPGHRISSSSLEAFSTGD 544
            :||..:.||:|.:      :.||         ::||:.::|.:..:.......:.|.|::
Mouse   585 SLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESSALQSQVDNLSCTESQLQS----- 644

  Fly   545 KGNCVIMDEVNFQYLKHVIVKFLTSREVEARHL----------VRAVSTLL-----QLTTEEEK 593
              .|..|.:.| :.|:..::|....|:.|.:.|          |:|:||.:     :|.|:..|
Mouse   645 --QCQQMGQAN-RNLESKLLKEEELRKEEVQTLQAELSAAQTEVKALSTQVEELKDELVTQRRK 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Golgin97	NP_610875.1	SMC_prok_B	<71..465	CDD:274008	100/488 (20%)
		Grip	553..598	CDD:197860	13/56 (23%)
Ccdc186	NP_739563.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..118		3/20 (15%)
		SMC_prok_B	<264..593	CDD:274008	78/374 (21%)
		EnvC	527..>726	CDD:443969	39/187 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..769		2/5 (40%)