DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cbs and golga1

DIOPT Version :9

Sequence 1:	NP_610875.1	Gene:	cbs / 36492	FlyBaseID:	FBgn0086757	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_002941692.1	Gene:	golga1 / 100492910	XenbaseID:	XB-GENE-995783	Length:	835	Species:	Xenopus tropicalis

Alignment Length:	840	Identity:	202/840 - (24%)
Similarity:	342/840 - (40%)	Gaps:	253/840 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFATLKNKIKEETGDDVVQSANQRYPGNNNNNYRLRSRR--VSINSNSADDVGGGGFYNE---SE 60
            ||..||.||.||       :|....||......|..||.  .|..::|.||....|..:.   |.
Frog     1 MFTKLKKKIAEE-------AAVAPRPGGAARIPRTISRESITSAGADSGDDFASDGSSSREDLSS 58

  Fly    61 QLCELRSQCNELTTKLSTVTQGLQQLQEEKTRVDKTNEILLE-----SVRVAQTQKDIY------ 114
            |:.....|...|..||....:.::.||:.|.::    |:.||     |:|..|.|.:.|
Frog    59 QISRKNEQIRRLEAKLMEYAEQVRNLQKMKDKL----EVALEKHQDSSMRKFQEQNEAYQANRAK 119

  Fly   115 ----------CEEQEKIQNLQQIEIDKLK-----------NLLSFREQESVDRM-GLMRQQTQQI 157
                      .::||.::.|..:|.:|.|           |:..|:::|.:|.: |..:|:..:|
Frog   120 MAEGFALALEKKDQEWMEKLADLEEEKKKLSDQLVSMTKQNMSFFKKREDLDELEGFQQQELAKI 184

  Fly   158 ESLSEELERLRPIESVAEDLRDELEQLRHS--TQQEKNLLTTTLAA----VQEENRHL------- 209
            :.:..:.|.:  :..:.|||:.:.|:...|  ..|:.:.|:..|:|    :||||..|
Frog   185 KHMLLQKEEM--LWKIEEDLKRQREEAEASLVELQDSSCLSAKLSADIQKLQEENTELAQKRSEL 247

  Fly   210 ------------------------------------------KKRMKIVE--------------- 217
                                                      ||::..|:
Frog   248 VAAQEGATIKITELEDRQTELQDFIQRLSLDLQEAQSSASSCKKKLNSVQADYEDLSLQHSQLKA 312

  Fly   218 ----------------ESRLESL-----GKLNSEQQVQALIREHKLLEQHLEEAHLQLSDIKGSW 261
                            :.::.||     |..:.|:.:|||::|...||..|.|:..:|.:.|...
Frog   313 KMSTEAESKEVLIMRLQEKVSSLEKTLDGTYSGEEGLQALLKEKNDLEVRLNESKQELLEGKAMH 377

  Fly   262 SGQNLALETQVSRLSKQVA----------EETTEKRKALKSRDDAIESRKQVSFE-LEKAKDEIK 315
            ......||.|.::|:.::.          ||.|..::...|....||.:.:.:.| |:|.::|:.
Frog   378 KDTICQLENQAAKLTSRIQEMENVLHQKDEELTLFKQKSASELKEIEQKLETTHEKLQKQEEELN 442

  Fly   316 QRDDKVKLLEEEID--------ELSVALKECRE------------------------------EN 342
            :|:.::|.|:.:::        :|:....:|.|                              |.
Frog   443 ERESQIKSLQSDLESECSRLTQQLNSVKHQCAEKVERLEAQVSALEGAREFDKAAAQHQVKQLEQ 507

  Fly   343 EQQVLFERNKS-----QNLETEVKDLKTRLTAADDRFSEYSSNAEQV-AQKLRVQ---------V 392
            :..:|.|||:.     ::.|.|.:.::..|::.:....|.:...|:. .||..:|         :
Frog   508 DNTLLKERNEELERALRHQEAEQEKMREELSSRETVSVEIAKALEETRKQKEELQQQVASLSNII 572

  Fly   393 TEKQEQLDETIMQLEIEREEKMT------AIL------------RNAEIAQSEDILRQQLRLERS 439
            ||.:::|.:....|:.:.||..:      |||            ...::.|||:...:|:|..|.
Frog   573 TENEKELAQRTEALQGKEEEAASLKRDYDAILLQVSQHQSQLETYKTQMEQSEESTEKQVRTMRM 637

  Fly   440 EASDLQERNNQLVRDISEARQTLQQVS--------STAQD-----NADKLTEFERVQLE----II 487
            :   |||....|:...|:.....::||        |.||:     .|..:.:.::..||    |.
Frog   638 Q---LQEHKQALLTSESQVSSLQEEVSALHEHLHGSNAQELNGDVTAGDIAQLQKENLEMGQQIA 699

  Fly   488 EKNKTIKTLNQRLIDLKKTVQKELRSAQISTDSESHPTTTPGHRISSSSLEAFSTGDKGNCVIMD 552
            |||||||.|.||:.:||||:||||:.......:|......|...:.|.::       ..|..:.|
Frog   700 EKNKTIKQLQQRMAELKKTLQKELKIKPEPEVNEVQEKQNPEPALPSLTV-------TNNADLND 757

  Fly   553 --EVNFQYLKHVIVKFLTSREVEARHLVRAVSTLLQLTTEEEKLLHDTLNWKMSWFGMKP 610
              |:||:|||||::||:::||.||.||::|||.||..:.|||.||.:||.:||||||.||
Frog   758 SREINFEYLKHVVLKFMSARETEAFHLIKAVSVLLNFSVEEENLLKETLEYKMSWFGSKP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cbs	NP_610875.1	AmyAc_family	<276..>372	CDD:298606	24/149 (16%)
cbs	NP_610875.1	Grip	553..598	CDD:197860	26/44 (59%)
golga1	XP_002941692.1	Smc	<50..721	CDD:224117	138/679 (20%)
golga1	XP_002941692.1	Grip	760..805	CDD:197860	26/44 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6868
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I3994
OMA	1	1.010	-	-		QHG47149
OrthoDB	1	1.010	-	-		D414719at33208
OrthoFinder	1	1.000	-	-		FOG0007916
OrthoInspector	1	1.000	-	-		oto104107
Panther	1	1.100	-	-	LDO	PTHR23157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5125
SonicParanoid	1	1.000	-	-		X5869
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110