DRSC/TRiP Functional Genomics Resources

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Protein Alignment cnn and PDE4DIP

DIOPT Version :9

Sequence 1:NP_001246293.1 Gene:cnn / 36491 FlyBaseID:FBgn0013765 Length:1378 Species:Drosophila melanogaster
Sequence 2:XP_006711705.1 Gene:PDE4DIP / 9659 HGNCID:15580 Length:2592 Species:Homo sapiens


Alignment Length:1829 Identity:352/1829 - (19%)
Similarity:635/1829 - (34%) Gaps:567/1829 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDQSKQVLRDYCGDGNGTCASSLKEIT-LIETVTSFLEENGAAEIDRRVLRKLAEALSKSIDD-- 62
            :.:.:::|:|...|.|........||. |:::|::..:|:.||      ..||.:||.:...:  
Human   783 LQRKERMLQDLLSDRNKQVLEHEMEIQGLLQSVSTREQESQAA------AEKLVQALMERNSELQ 841

  Fly    63 ----------------------------------TSPGALQ-----DVTMENSYASFDVPRPPGG 88
                                              |..|::|     |.|...:.....:||...|
Human   842 ALRQYLGGRDSLMSQAPISNQQAEVTPTGRLGKQTDQGSMQIPSRDDSTSLTAKEDVSIPRSTLG 906

  Fly    89 GNSPLPSQGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAK-IEIA 152
            ...       :|..||:::|..::|   |:|......|.|....|..|..::.::.:..: .::.
Human   907 DLD-------TVAGLEKELSNAKEE---LELMAKKERESQMELSALQSMMAVQEEELQVQAADME 961

  Fly   153 TLRKTVDVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTR 217
            :|.:.:.:|.:|:||....:...|::.....:..:.::  |:|::.:   .||.||.:....:.:
Human   962 SLTRNIQIKEDLIKDLQMQLVDPEDIPAMERLTQEVLL--LREKVAS---VESQGQEISGNRRQQ 1021

  Fly   218 KMLRLE---SEVQRLEEEL---------------------------VNIEARNVAARNELEFMLA 252
            .:|.||   .|..||.|.|                           |.:|...| .|:.||.:|.
Human  1022 LLLMLEGLVDERSRLNEALQAERQLYSSLVKFHAHPESSERDRTLQVELEGAQV-LRSRLEEVLG 1085

  Fly   253 ------ERLESLTACEG----------------KIQELAIKNS--ELVE-RLEKETASAESSNEA 292
                  .|||:|.|..|                .|:|.|..:|  :||: .|||..|:.|:.|.:
Human  1086 RSLERLNRLETLAAIGGAAAGDDTEDTSTEFTDSIEEEAAHHSHQQLVKVALEKSLATVETQNPS 1150

  Fly   293 I--------DS----------LKVE----LEACRKENQDLVTSIRTLKHDMKRQVR-----SMKE 330
            .        ||          |:.|    ||..||..::|        .::|.|:.     |:..
Human  1151 FSPPSPMGGDSNRCLQEEMLHLRAEFHQHLEEKRKAEEEL--------KELKAQIEEAGFSSVSH 1207

  Fly   331 AANTMDVQRQSILLLEATIK-------------RKEKSCGS-MQKNVLNYEALI-AKLNAELETM 380
            ..|||    .|:.|..|.:|             .::|..|. |.:.|:..|.|. :.|.||...:
Human  1208 IRNTM----LSLCLENAELKEQMGEAMSDGWEIEEDKEKGEVMVETVVTKEGLSESSLQAEFRKL 1268

  Fly   381 RQQNVYFRELSENLQQKEVRQLDRGVAIVQP--------------MRMTADAGRFVWQSGTIVAQ 431
            :.:......:...|:::.|.....|.:.:.|              ..:....|:...|....|..
Human  1269 QGKLKNAHNIINLLKEQLVLSSKEGNSKLTPELLVHLTSTIERINTELVGSPGKHQHQEEGNVTV 1333

  Fly   432 EPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGH 496
            .|.| ..||....:..:|.|.:|.:...|....|.:..                   ::|.:..|
Human  1334 RPFP-RPQSLDLGATFTVDAHQLDNQSQPRDPGPQSAF-------------------SLPGSTQH 1378

  Fly   497 LALKIILLAMRLHSCLQNVHIPLRANRDLGAQ-LADKICELQEAQEKLKER-----ERIHEQACR 555
                   |..:|..|.|..       :||..: |..:.....:|.|..|.|     |.:.:|..:
Human  1379 -------LRSQLSQCKQRY-------QDLQEKLLLSEATVFAQANELEKYRVMLTGESLVKQDSK 1429

  Fly   556 TIQKLMQKLSSQEKEIKKLNQENEQSANKE----NDCAKTVISP---SSSGRSMSDNEASSQE-- 611
            .||..:|.|..:.....:...|.|::.:.|    |...:.|:..   |..||..|...:||:.  
Human  1430 QIQVDLQDLGYETCGRSENEAEREETTSPECEEHNSLKEMVLMEGLCSEQGRRGSTLASSSERKP 1494

  Fly   612 MSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQNLVNKELWE-KNR------------EVERL 663
            :...|..:.|.::..:.|.|..|:.::|...|.||| .||.:.. |:|            .:||.
Human  1495 LENQLGKQEEFRVYGKSENILVLRKDIKDLKAQLQN-ANKVIQNLKSRVRSLSVTSDYSSSLERP 1558

  Fly   664 TKLLANQQKTLPQISEESAGEAD---LQQSFTEAEYMRALERNK----LLQRKVDV--------L 713
            .||.|  ..||...|..|..:.|   |... |.|.|...|:..|    |:||...:        |
Human  1559 RKLRA--VGTLEGSSPHSVPDEDEGWLSDG-TGAFYSPGLQAKKDLESLIQRVSQLEAQLPKNGL 1620

  Fly   714 FQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLECVDVCSVLTNRLEELAGFLNSLLKHKDV 778
            .::||::.::::..|:....:|....|:....:...|...:|.::|...::.......||:..|:
Human  1621 EEKLAEELRSASWPGKYDSLIQDQARELSYLRQKIREGRGICYLITRHAKDTVKSFEDLLRSNDI 1685

  Fly   779 ---LGVLAADRRNAMRKAVDRSLDLSKSLNMTLNITATSLADQSLAQLCNLS------------- 827
               ||       .:.|:.:.:...|::.|...|: |....:::..|.|..|:             
Human  1686 DYYLG-------QSFREQLAQGSQLTERLTSKLS-TKDHKSEKDQAGLEPLALRLSRELQEKEKV 1742

  Fly   828 -EILYTEGDA-------SHKTFNSH----------EELHAATSMAPTVENLKAENK--------- 865
             |:|..:.||       ||...:||          :||.|.:.|....|....|.|         
Human  1743 IEVLQAKLDARSLTPSSSHALSDSHRSPSSTSFLSDELEACSDMDIVSEYTHYEEKKASPSHSDS 1807

  Fly   866 --------ALKKELEKRRSSEGQRKERRSLP--LPSQQFDNQSESEAWS-----EPDRKVSLARI 915
                    .|..:.....:|:|.:.|..|.|  ||:.|...:..::|.|     ...:..||.:.
Human  1808 IHHSSHSAVLSSKPSSTSASQGAKAESNSNPISLPTPQNTPKEANQAHSGFHFHSIPKLASLPQA 1872

  Fly   916 GLDETSNSL--------------AAPEQAISESESEGRTCATRQDRNRNSERIAQLEEQIAQKDE 966
            .|....:|.              ..|..:::|::.|                :..|::|:.:...
Human  1873 PLPSAPSSFLPFSPTGPLLLGCCETPVVSLAEAQQE----------------LQMLQKQLGESAS 1921

  Fly   967 RM-----LNVQCQMVELDNRYKQEQLR-------CLDITQQLEQ-----------LRAINEALTA 1008
            .:     ..:....:|.|:.|.....:       .:::.:.||.           :|....:::.
Human  1922 TVPPASTATLLSNDLEADSSYYLNSAQPHSPPRGTIELGRILEPGYLGSSGKWDVMRPQKGSVSG 1986

  Fly  1009 DLHAIGSHE-------------EERMVELQRQLELKNQQI---DQLK--LAHS-TLTA------- 1047
            ||.: ||..             ||.:.|::...:...:.|   |:|:  |.|. |.||       
Human  1987 DLSS-GSSVYQLNSKPTGADLLEEHLGEIRNLRQRLEESICINDRLREQLEHRLTSTARGRGSTS 2050

  Fly  1048 ---------------DSQITEMELQALQQQMQEIEQLHADSVETLQSQLQKLKLDAVQQLE---E 1094
                           ::::...:.:.||.|:..:.:.|:...|:|:..|...: ..:|:||   |
Human  2051 NFYSQGLESIPQLCNENRVLREDNRRLQAQLSHVSREHSQETESLREALLSSR-SHLQELEKELE 2114

  Fly  1095 HERLHREALERDWVALTTYQEQAQQLLELQRSLDYHQENEKELKQTLVENELATRALKKQLDE-- 1157
            |:::.|:.|..|      .:|:.|::|..:......|||:..|:..||       .|::|.:|  
Human  2115 HQKVERQQLLED------LREKQQEVLHFREERLSLQENDSRLQHKLV-------LLQQQCEEKQ 2166

  Fly  1158 ---STLQASKAVMER--------TKAY-----------NDKLQLEKRSEELRLQLE-------AL 1193
               .:||:...:.|.        .|||           :|...|......||.|||       .|
Human  2167 QLFESLQSELQIYEALYGNSKKGLKAYSLDACHQIPLSSDLSHLVAEVRALRGQLEQSIQGNNCL 2231

  Fly  1194 KEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATTCKQAAAAVLGQRVNTSSPDLGIESD 1258
            :.:.|:.|:..:..:.:|.|.......|  ...|..:....:.:|.:...:.|..:||.|...|.
Human  2232 RLQLQQQLESGAGKASLSPSSINQNFPA--STDPGNKQLLLQDSAVSPPVRDVGMNSPALVFPSS 2294

  Fly  1259 AGRISSVEVSNAQRA---------MLKTVEMKTEGSASP-------------------------- 1288
            |......|.....||         ::|| ..|.||.|:.                          
Human  2295 ASSTPGSETPIINRANGLGLDTSPVMKT-PPKLEGDATDGSFANKHGRHVIGHIDDYSALRQQIA 2358

  Fly  1289 ----------------------KAKSEESTSPDSKSNVATGAATVHDCAK--------------- 1316
                                  :|:..|.........:.:..:.:|...:               
Human  2359 EGKLLVKKIVSLVRSACSFPGLEAQGTEVLGSKGIHELRSSTSALHHALEESASLLTMFWRAALP 2423

  Fly  1317 --------------VDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVL 1367
                          .:.|..|||.|:.:.:|..:.|.|.|:.||:.|..:|:.|.:|:.:||:||
Human  2424 STHIPVLPGKVGESTERELLELRTKVSKQERLLQSTTEHLKNANQQKESMEQFIVSQLTRTHDVL 2488

  Fly  1368 RNVRSNMEN 1376
            :..|:|:|:
Human  2489 KKARTNLES 2497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnnNP_001246293.1 Cnn_1N 101..170 CDD:285263 15/69 (22%)
HMMR_N 891..1203 CDD:292527 76/428 (18%)
FAM76 <1019..1087 CDD:292665 17/95 (18%)
PDE4DIPXP_006711705.1 zf-AD 4..74 CDD:285071
TMPIT 405..>500 CDD:285135
COG1340 414..714 CDD:224259
SMC_prok_B 518..1282 CDD:274008 107/532 (20%)
DUF1220 1726..1787 CDD:284231 12/60 (20%)
SPICE <2092..2155 CDD:292306 18/69 (26%)
eIF_4EBP 2278..>2325 CDD:283183 11/47 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I11023
eggNOG 1 0.900 - - E1_2BXW1
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 167 1.000 Inparanoid score I4165
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR46501
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4875
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
66.080

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