Protein Alignment cnn and Pde4dip

DIOPT Version :10

• Sequence 1: NP_001246293.1
• Gene: cnn / 36491
• FlyBaseID: FBgn0013765
• Length: 1378
• Species: Drosophila melanogaster
• Sequence 2: NP_001276630.1
• Gene: Pde4dip / 83679
• MGIID: 1891434
• Length: 2463
• Species: Mus musculus
• Alignment Length: 1637
• Identity: 344/1637 - (21%)
• Similarity: 607/1637 - (37%)
• Gaps: 578/1637 - (35%)

  Fly    75 NSYASFDVPRPPGGGNSPLPSQGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTES 139
            :|..:|:.|        || .|.:::|:.|:.::.|:||||:|||||||||| :...:.:.|.|.
Mouse   109 HSLRAFEKP--------PL-VQTQALRDFEKHLNDLKKENFSLKLRIYFLEE-RMQQKYEVSRED 163

  Fly   140 LSKQLIDAKIEIATLRKTV-DVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQI-HAYQ- 201
            :.|:.|:.|:|:.:|::.: |.|..|.|..|.|    |:|..:.:.:.:..::|.|::. |.|:
Mouse   164 VYKRNIELKVEVESLKRELQDRKQHLDKTWADA----EDLNSQNEAELRRQVEERQQETEHVYEL 224

  Fly   202 -------------MAESGGQPVENIAKTRKMLRLESEVQRLEEELVNIEARNVAARN-------- 245
                         :|::....:|.:.:..|...||     |.|...|      ||:|
Mouse   225 LGNKIQLLQEEPRLAKNEATEMETLVEAEKRCNLE-----LSERWTN------AAKNREDAAGDQ 278

  Fly   246 ----ELEFMLAER-------LESLTACEGKIQELAIKNSELVERLEKETASAE------------ 287
                :....||:|       .:||.|.||.:::|:.:..:|:..|| |.||.|
Mouse   279 EKPDQYSEALAQRDRRIEELRQSLAAQEGLVEQLSQEKRQLLHLLE-EPASMEVQPVPKGLPTQQ 342

  Fly   288 -------------SSNEAIDSLKVELEACRKENQDLVTSIRTLKHDMKRQVRSMKEAANTMDVQR 339
                         .|...:..|:.:::.....|:.|...:    :|:..:::|.:|::...|...
Mouse   343 KPDLHETPTTQPPVSESHLAELQDKIQQTEATNKILQEKL----NDLSCELKSAQESSQKQDTTI 403

  Fly   340 QSILLLEATIKRKEKSCGSMQKNVLNYEALIAKLNAELETMR-------------QQNVYFRELS 391
            ||   |:..:|.:|.....:.:.:......:|||...|...:             ||.|...:|.
Mouse   404 QS---LKEMLKSRESETEELYQVIEGQNDTMAKLREMLHQSQLGQLHSSEGIAPAQQQVALLDLQ 465

  Fly   392 ENL--QQKEVRQLDRGVAIVQPMRMTADAGRFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRL 454
            ..|  .|.|:::|.|  .:.|..|..||..|.| |.....|||   .|.|..||..
Mouse   466 SALFCSQLEIQRLQR--LVRQKERQLADGKRCV-QLVEAAAQE---REHQKEAAWK--------- 515

  Fly   455 SSGPPPDQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPL 519
                          |::                 .:..||.|       |...|||..|.:|: |
Mouse   516 --------------HNQ-----------------ELRKALQH-------LQGELHSKSQQLHV-L 541

  Fly   520 RANR------------DLGAQLADKICELQEAQEKL------------------KERERIHEQAC 554
            .|.:            .|...|:.|...:||.||.|                  |.|:||.::|.
Mouse   542 EAEKYNEIRTQGQNIQHLSHSLSHKEQLIQELQELLQYRDNADKTLDTNEVFLEKLRQRIQDRAV 606

  Fly   555 RTIQKLMQKLSSQEKEIKKLNQENEQSANKEND-----CAKTVISPSSSGRSMSDNEASSQEMST 614
            ...:.:.:|.|:.|::.|:|.|......::::|     |.            :|.|||:.|.|.:
Mouse   607 ALERVIDEKFSALEEKDKELRQLRLAVRDRDHDLERLRCV------------LSANEATMQSMES 659

  Fly   615 NLRVRYELKINEQEEKIKQLQTEVKKKTANLQNL--VNKEL------WEKNRE--VERLTKLLAN 669
            .||.|               ..||::.||..|||  :.:||      |:|.:|  :::|...|.:
Mouse   660 LLRAR---------------GLEVEQLTATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHD 709

  Fly   670 QQKTLPQIS-----EESAGEADLQQSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQ 729
            :.|.:..:|     :...|::::.:...:.           |||| :.:.|.|..|:...||..:
Mouse   710 RNKEVEDLSATLLCKLGPGQSEVAEELCQR-----------LQRK-ERMLQDLLSDRNKQAVEHE 762

  Fly   730 LRLELQQARTEVETADKWRLECVDVCSVLTNRLEELAGFLNSLLKHKDVLGVLAADRRNAMRKAV 794
            :                                 |:.|.|.|       :|....:|:.|..|.|
Mouse   763 M---------------------------------EIQGLLQS-------MGTREQERQAAAEKMV 787

  Fly   795 DRSLDLSKSLNMTLNITATSLADQSLAQLCNLSEILYTEGDASHKTFNSHEELHAATSMAPTVEN 859
            ...::.:..|             |:|.|.....|::     .|.:||.|::.. ..||:.|
Mouse   788 QAFMERNSEL-------------QALRQYLGGKELM-----TSSQTFISNQPA-GVTSIGP---- 829

  Fly   860 LKAENKALKKELEKRRSSEGQRKERRSLPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSNSL 924
                             ..|::.::.|:.:||:  |:.:...|..|    .|:.|..|.: |:::
Mouse   830 -----------------HHGEQTDQGSMQMPSR--DDSTSLTAREE----ASIPRSTLGD-SDTV 870

  Fly   925 AAPEQAISESESEGRTCATRQDRNRNSE-RIAQLEEQIAQKDERMLNVQCQMVELDNRYKQEQLR 988
            |..|:.:|.::.|....|.::   |.|: .::.|:..:|.::|.:   |.|..:|::..:..|::
Mouse   871 AGLEKELSNAKEELELMAKKE---RESQMELSALQSMMAMQEEEL---QVQAADLESLTRNVQIK 929

  Fly   989 ---CLDITQQL---EQLRAINEALTADLHAIGSHEEERMVELQRQLEL---KNQQ--------ID 1036
               ..|:..||   |.:.|: |.||.::..:  .|:...||.|.| |:   |.||        :|
Mouse   930 EDLIKDLQMQLVDPEDIPAM-ERLTQEVLLL--REKVASVEPQGQ-EVSGNKRQQLLLMLEGLVD 990

  Fly  1037 QLKLAHSTLTADSQI-------------------TEMELQALQQQMQEIEQLHADSVETLQSQLQ 1082
            :....:..|.|:.|:                   .::||:..|.....:|::...|:|.| |:|:
Mouse   991 ERSRLNEALQAERQLYSSLVKFHAQPENSERDGTLQVELEGAQVLRTRLEEVLGRSLERL-SRLE 1054

  Fly  1083 KL---------------KLDAVQQLEE------HERLHREALERDWVALTTYQEQ---------- 1116
            .|               ..:....:||      |::|.:.|||:   :|.|.:.|
Mouse  1055 SLAAIGGATAGNETEDTSTEFTDSIEEEAAHTSHQQLIKVALEK---SLATMETQNICLQPPSPV 1116

  Fly  1117 --------AQQLLELQRSLDYHQENE-------KELK---------------QTLVENELATRAL 1151
                    .:::|.|:..:..|.|.:       ||||               .|::...|....|
Mouse  1117 GEDSNRCLQEEMLHLRAEIHQHLEEKRKAEVELKELKAQIEEAGFSSVSHIRNTMLSLCLENAEL 1181

  Fly  1152 KKQ------------------------------LDESTLQAS-KAVMERTK-AYND----KLQLE 1180
            |:|                              |:|::|||. :.|..:.| |||.    |.||.
Mouse  1182 KEQMGEAMSDGWEVEEDKEKGEVMLETVVAKGCLNENSLQAEFRKVQGKLKSAYNIINLLKEQLL 1246

  Fly  1181 KRSEE----------LRLQLEA----------LKEEHQKLLQKRS-------------------- 1205
            .||.|          :||..|.          .|.:||:  |:.:
Mouse  1247 LRSSEGNSKEMPELLVRLAREVDRMNTGLPSLGKHQHQE--QENTTTARPGSRPQSLPLGAALSV 1309

  Fly  1206 ------NSSDVSQSGYTSEEVAVPMGPP--SGQATTCKQ-----------AAAAVLGQRVNTSSP 1251
                  |.|....||: ..|.::|....  ..|...|:|           :.|.|..| .|....
Mouse  1310 DGYQLENKSQAQDSGH-QPEFSLPGSTKHLRSQLAQCRQRYQDLQEKLLISEATVFAQ-ANQLEK 1372

  Fly  1252 DLGIESDAGRISSVEVSNAQ-RAMLKTVEMKTEGSASPKAKSEESTSPDSKSN-------VATGA 1308
            ...:.|:    |.|:..:.| :..|:.:..:|.|.:..:|:.||:|||:.:.:       :..|.
Mouse  1373 YRAVFSE----SLVKQDSKQIQVDLQDLGYETCGRSENEAEREETTSPECEEHNNLRPVVLMEGL 1433

  Fly  1309 AT---------VHDCAKVDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTH 1364
            .:         |...||..|||...:::..|.....:|: ..||       :..:|:|.|:...:
Mouse  1434 CSEQGYLDPVLVSPPAKKPLENKPGKQEEFRAHGTPDDS-SLLR-------KDIRDLKAQLQNAN 1490

  Fly  1365 NVLRNVRSNMEN 1376
            .|::|:||.:.:
Mouse  1491 KVIQNLRSRVRS 1502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:462333	28/69 (41%)
		Smc	<138..>404	CDD:440809	70/340 (21%)
		SMC_prok_B	498..1200	CDD:274008	186/905 (21%)
		Smc	<929..>1247	CDD:440809	101/510 (20%)
Pde4dip	NP_001276630.1	Cnn_1N	126..193	CDD:462333	28/67 (42%)
		SMC_prok_B	<151..419	CDD:274008	60/291 (21%)
		SMC_prok_B	360..1160	CDD:274008	202/1000 (20%)
		SMC_prok_B	875..>1613	CDD:274008	133/658 (20%)
		Olduvai	1677..1742	CDD:429104
		Smc	<1963..>2202	CDD:440809