DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnn and pde4dip

DIOPT Version :9

Sequence 1:	NP_001246293.1	Gene:	cnn / 36491	FlyBaseID:	FBgn0013765	Length:	1378	Species:	Drosophila melanogaster
Sequence 2:	XP_031756145.1	Gene:	pde4dip / 780348	XenbaseID:	XB-GENE-982015	Length:	2517	Species:	Xenopus tropicalis

Alignment Length:	1950	Identity:	350/1950 - (17%)
Similarity:	637/1950 - (32%)	Gaps:	746/1950 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDQSKQVLRDYCGD---------GNGTCASSL------KEITL---------IETVTSFLEENGA 41
            :.|.|.::|:...|         ||....:||      |::.|         :|.:...:||...
Frog   675 IQQLKMIIREKQRDLERLQSVLSGNEETINSLDNLMKSKDLELEHISAAYKNLEWLKQEMEEKNQ 739

  Fly    42 AEIDRR--VLRKLAEAL---SKSIDDTSPGALQDVTMENSYASFDVPRP------------PGGG 89
            ..:..|  ::::|.:||   ||.|.|.....||    ::...|||:.:.            ....
Frog   740 RSLKERDSIIQQLQQALQDRSKEIQDMMATFLQ----KSEMGSFDLIQELQACLECKEKMLQEAL 800

  Fly    90 NSPLPSQGRSVRELEEQMSALRKENFNLKLRIYF------LEEGQ-------------------- 128
            ::........:|||||.::::..|    |:..:|      |:|.|
Frog   801 HNRSQQADEHMRELEELLTSMASE----KMGQWFVCKSCALKEKQNSEMDQSPACQKTVKQLAKA 861

  Fly   129 ---------------------PGARADSSTESLSKQLIDAK--------------IEIATLRKTV 158
                                 |.....:.||:|..:|..||              ||::.|:..:
Frog   862 KPLSDHPISVCVTSLSADLKDPAVAQSNQTEALESELAKAKDDLQLVLRKERENQIEVSALQSVI 926

  Fly   159 DVKMELLKDAA-------RAISHHEELQRKADIDSQAI-------IDELQEQIHAY--QMAESG- 206
            ..:.|.|::.|       |:|...|:|.:  |:..|.:       ::.|.:::.:.  ::|.||
Frog   927 REQSEQLQEQAADMDALNRSIQIKEDLIK--DLQMQLVDPEEVPTVEHLTQEVLSLKEKLAISGV 989

  Fly   207 GQPVENIAKTRKMLRLESEV----------------------------------QRLEEELVNIE 237
            .:|...|...:|:.:|..|:                                  ..|:|||:..:
Frog   990 PEPEHGIDHYQKLSKLLEELVADRSRLNDALHAEKQLYSSLVQFHSDPDSIKRTSALQEELLTAQ 1054

  Fly   238 ARNVAARNELEFMLAERLESLTACEG-------------KIQELAIKNSELVERLEKET------ 283
            .......:.|| |..|||..|.:..|             .:.|  ..:|:..:.:|.:|
Frog  1055 TLTCQLEDTLE-MATERLRQLDSERGLTAITFGGLKEDNDVDE--DSSSQFSDSIEDDTDYQSNG 1116

  Fly   284 ASAESSNEAIDS----------LKVELEACRKENQDLVTSIRTLKHDMKRQVRSMKEAANTMDVQ 338
            ...:...:::||          |:.||.:.|.|.|. |..::|...:..|.::|..|.|...|..
Frog  1117 QGPKPQADSMDSAPIVANGDKDLQNELLSVRNELQQ-VMEVKTKTEEELRILKSRLEEAGISDAA 1180

  Fly   339 --RQSILLL-----EATIKRKEKSCGSMQKNVLNYEALIAK--LNAELE----TMRQQNVYFREL 390
              |.::.:|     |..::.:.:..|..:...:..|.|...  |..||.    .|||.....:.|
Frog  1181 DFRNALQILCQKRNEWNVEMESEKLGQWEDEKMEEEGLSVDKGLRVELRKLQGKMRQAETVIKHL 1245

  Fly   391 SENLQQKEVRQLDRGVAIVQPMRMTADAGRFVWQSGTIVAQEPLPLER-QSAAATSNVSVSAVRL 454
            .|.|                .:.....||.|   :..::....:.:|| ::..|::.:..|||
Frog  1246 KEQL----------------ALNSQDGAGTF---NPDLIVSMAVEIERLKTEKASATMKRSAV-- 1289

  Fly   455 SSGPPPDQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPL 519
            .:..|.::|                .....:|.|:..:.           ....|...|..|:
Frog  1290 VNEQPEEET----------------SKRHCNWNSSGDVG-----------EPEKHGTKQKPHV-- 1325

  Fly   520 RANRDLG------------------AQLADKICELQEAQEKL-KERERIH--------------- 550
             ..::||                  ::||.::.:.||.|:|| |....:|
Frog  1326 -VQKELGSDWQENEANLEVQTMQLRSELAQRVRQNQELQDKLVKSEATVHAQTDQLKQYRGLLNE 1389

  Fly   551 ---EQACRTIQKLMQKLSSQ-----EKEIKKLNQENEQSANKENDCAKTVIS-------PSS--- 597
               ||..:.:|...|.|..:     |.|:     :.|:|.:.|.:..:.:.|       |||
Frog  1390 SLVEQDSKQVQVDFQDLGYETCGRSENEV-----DREESTSPEYEEHEELFSENSLMEEPSSPYK 1449

  Fly   598 ------SGRSMSDNEASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQNLVNK----- 651
                  :...:.:||....:.:.:.....::.:.:|.  :|.|:.:::|....:.||.::
Frog  1450 GWSPLVTSSPLKNNECGQNDWTLDWEKSEDVTVLQQH--VKNLKVQLQKAQKVISNLQSRARSFS 1512

  Fly   652 -----------------------------ELWEKNREVERLTKLLANQQKTLPQISEE-SAGEAD 686
                                         |.|:.:       .:..|..|.|.|:.:. |..||.
Frog  1513 ASSDYANHHRLKHSVSFHGSTSHSITDEDEGWQSD-------TVGVNSTKDLEQLVQRVSMLEAQ 1570

  Fly   687 LQQSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLEC 751
            |.||..:......: ::.....|.|.|.|..|.:      :..||.:|::.|:
Frog  1571 LHQSHRDVGAQDQI-KSATWPGKYDSLIQAQARE------LSLLRQKLREGRS------------ 1616

  Fly   752 VDVCSVLTNRLEELAGFLNSLLKHKDV-------------LGVLAADRRNAMRKAVDRS------ 797
              ||.:||..|.:.......||:..|:             .|...|:|.|....:.:||
Frog  1617 --VCHILTQHLGDTIKSFEELLRANDIDYYMGQGFREQLTQGTQLAERLNNKLNSKERSDVDDKS 1679

  Fly   798 ------LDLSKSLNMTLNIT------------------ATSLADQSLA-------QLCN------ 825
                  :.|||.|.....|.                  |.|.:|||..       ||.|
Frog  1680 RHELLAIRLSKELQQKDKIIESLQSKLEGHSLTPSSSHAISESDQSDRTSFVSDDQLSNNDDLDG 1744

  Fly   826 ---------------LSEILYTEGDASH----KTFNSHE-----ELHAATSMAPTVENLKA---- 862
                           :::.::.:..|||    ....|||     :||..::...:.|.|:.
Frog  1745 CSEVATASDYTRSTHVADAIHIDNVASHPAKPSLSTSHEVQQQPKLHVKSAQPHSAETLQGHFIP 1809

  Fly   863 -----------------------------------------ENKALKKELEKRRSSEGQRKERRS 886
                                                     |...|:|:|.:            |
Frog  1810 PPSSVNVLSAALPPSAPFPPFGAHPPMVSGPPVFSLAEVQQELHILQKQLAE------------S 1862

  Fly   887 LPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPE---QAISESESEGRTCATR---- 944
            :|:.|...              :.:.|.....:|:.|...|.   |.:.:..|   |.||:
Frog  1863 MPMASSAI--------------RPAHASTSFFDTTTSSVFPSYFPQPLHDIPS---TTATQNAPG 1910

  Fly   945 ----QDRNRNSERIAQLEEQIAQKDERMLNVQCQMVELDNRYKQ-EQLRCLDITQQ-LEQLRAIN 1003
                :....||..:..::..:...:.   ||........:.|:. .:|...|:.:: |.::|.:.
Frog  1911 FRAAETGFSNSSGLWDMQHLVRPVNG---NVHGDASSGSSGYQSASKLTGSDLLEEHLAEIRNLR 1972

  Fly  1004 EALTADLHAIGSHEEERMVELQRQLELKNQQIDQLKLA------------HS-----TLTADSQI 1051
            ::|...:|.     .:|   |:.|||      |:|..|            |.     .|:.:::.
Frog  1973 QSLEESIHM-----NDR---LRAQLE------DKLTAATKGSGPPTNIYIHGLESLPQLSNENRA 2023

  Fly  1052 TEMELQALQQQMQEIEQLHADSVETLQ-------SQLQKLKLDAVQQLEEHERLHREALERDWVA 1109
            ...|..:||.::.:|.:.:...:|.||       :||:.::.|..|:.:|.::|..|
Frog  2024 LREENLSLQVRINQISRDYFKELENLQKLLSSSRAQLKNVETDLEQKTQESKKLQEE-------- 2080

  Fly  1110 LTTYQEQAQQLLELQRSLDYHQENEKELKQ--TLVENELATRALKKQLDE-----STLQASKAVM 1167
               ..::.|::|.||:....:||....|:.  ||:|         :||:|     :::|:...|.
Frog  2081 ---LDQKQQEILHLQKERQSNQEKSNRLQHQATLLE---------QQLNENCQLVNSMQSELQVY 2133

  Fly  1168 ERTKAYNDKLQLEKRS-------------EELRLQLEALKEEHQKLLQK----RSNSSDVSQSGY 1215
            ||... :.||.|...|             .||..::.:|:.:.:|.:|.    |.|.....:..:
Frog  2134 ERLYG-SSKLVLSAFSGETYHSLPANYDFSELLSEVRSLRSQMEKSIQVNTSIRHNLEKQLEGSF 2197

  Fly  1216 TSEEVAVPMGPPS-GQATTCKQAAAAVLGQRVNTSSP--DLGIESDAGRISSVEVSNAQR----- 1272
            .:.|    |.|.| .....|:..|...|.|....|.|  |:|:.|.:....|....||..
Frog  2198 GANE----MRPSSINIFPLCEHTAKKQLFQDPIPSPPVRDVGMHSPSTFFPSSSFLNASHTAPVL 2258

  Fly  1273 --AMLKTVEMKTEGSASPKAKSE--ESTSPD---------------------------------- 1299
              ::|...:..:..|||.::|||  |..:||
Frog  2259 DLSLLNKAQEASCNSASGESKSEKLEGDAPDGSFANKNGRHVIGHIDDFTALKQQILEGKMLIQK 2323

  Fly  1300 ------SKSNVA-------------------TGAATVHDCAK----------------------- 1316
                  |..|:|                   :..:|:|...|
Frog  2324 METIMQSSLNIAFLEIHGTKALDYGSIKRLFSTTSTLHQILKESASLLGMFWRAALPNTQSATQQ 2388

  Fly  1317 ------VDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNME 1375
                  :..|..:|:.||...:.|.::..|.|:..|:||..:|..|.:|:.:||:||:..|||:|
Frog  2389 KKEEQAMKEEICQLKNKLKEQEVALQEAKEHLKSTNRAKESMEHFIVSQLTRTHDVLKKTRSNLE 2453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:285263	24/136 (18%)
		HMMR_N	891..1203	CDD:292527	70/368 (19%)
		FAM76	<1019..1087	CDD:292665	19/91 (21%)
pde4dip	XP_031756145.1	SMYLE_N	1..388	CDD:408397
		Smc	415..1241	CDD:224117	108/579 (19%)
		DUF1220	1681..1735	CDD:399619	10/53 (19%)
		Smc	<1936..>2194	CDD:224117	61/295 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46501
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100