Protein Alignment cnn and pde4dip

DIOPT Version :10

• Sequence 1: NP_001246293.1
• Gene: cnn / 36491
• FlyBaseID: FBgn0013765
• Length: 1378
• Species: Drosophila melanogaster
• Sequence 2: XP_031756145.1
• Gene: pde4dip / 780348
• XenbaseID: XB-GENE-982015
• Length: 2517
• Species: Xenopus tropicalis
• Alignment Length: 1950
• Identity: 350/1950 - (17%)
• Similarity: 637/1950 - (32%)
• Gaps: 746/1950 - (38%)

  Fly     1 MDQSKQVLRDYCGD---------GNGTCASSL------KEITL---------IETVTSFLEENGA 41
            :.|.|.::|:...|         ||....:||      |::.|         :|.:...:||...
 Frog   675 IQQLKMIIREKQRDLERLQSVLSGNEETINSLDNLMKSKDLELEHISAAYKNLEWLKQEMEEKNQ 739

  Fly    42 AEIDRR--VLRKLAEAL---SKSIDDTSPGALQDVTMENSYASFDVPRP------------PGGG 89
            ..:..|  ::::|.:||   ||.|.|.....||    ::...|||:.:.            ....
 Frog   740 RSLKERDSIIQQLQQALQDRSKEIQDMMATFLQ----KSEMGSFDLIQELQACLECKEKMLQEAL 800

  Fly    90 NSPLPSQGRSVRELEEQMSALRKENFNLKLRIYF------LEEGQ-------------------- 128
            ::........:|||||.::::..|    |:..:|      |:|.|
 Frog   801 HNRSQQADEHMRELEELLTSMASE----KMGQWFVCKSCALKEKQNSEMDQSPACQKTVKQLAKA 861

  Fly   129 ---------------------PGARADSSTESLSKQLIDAK--------------IEIATLRKTV 158
                                 |.....:.||:|..:|..||              ||::.|:..:
 Frog   862 KPLSDHPISVCVTSLSADLKDPAVAQSNQTEALESELAKAKDDLQLVLRKERENQIEVSALQSVI 926

  Fly   159 DVKMELLKDAA-------RAISHHEELQRKADIDSQAI-------IDELQEQIHAY--QMAESG- 206
            ..:.|.|::.|       |:|...|:|.:  |:..|.:       ::.|.:::.:.  ::|.||
 Frog   927 REQSEQLQEQAADMDALNRSIQIKEDLIK--DLQMQLVDPEEVPTVEHLTQEVLSLKEKLAISGV 989

  Fly   207 GQPVENIAKTRKMLRLESEV----------------------------------QRLEEELVNIE 237
            .:|...|...:|:.:|..|:                                  ..|:|||:..:
 Frog   990 PEPEHGIDHYQKLSKLLEELVADRSRLNDALHAEKQLYSSLVQFHSDPDSIKRTSALQEELLTAQ 1054

  Fly   238 ARNVAARNELEFMLAERLESLTACEG-------------KIQELAIKNSELVERLEKET------ 283
            .......:.|| |..|||..|.:..|             .:.|  ..:|:..:.:|.:|
 Frog  1055 TLTCQLEDTLE-MATERLRQLDSERGLTAITFGGLKEDNDVDE--DSSSQFSDSIEDDTDYQSNG 1116

  Fly   284 ASAESSNEAIDS----------LKVELEACRKENQDLVTSIRTLKHDMKRQVRSMKEAANTMDVQ 338
            ...:...:::||          |:.||.:.|.|.|. |..::|...:..|.::|..|.|...|..
 Frog  1117 QGPKPQADSMDSAPIVANGDKDLQNELLSVRNELQQ-VMEVKTKTEEELRILKSRLEEAGISDAA 1180

  Fly   339 --RQSILLL-----EATIKRKEKSCGSMQKNVLNYEALIAK--LNAELE----TMRQQNVYFREL 390
              |.::.:|     |..::.:.:..|..:...:..|.|...  |..||.    .|||.....:.|
 Frog  1181 DFRNALQILCQKRNEWNVEMESEKLGQWEDEKMEEEGLSVDKGLRVELRKLQGKMRQAETVIKHL 1245

  Fly   391 SENLQQKEVRQLDRGVAIVQPMRMTADAGRFVWQSGTIVAQEPLPLER-QSAAATSNVSVSAVRL 454
            .|.|                .:.....||.|   :..::....:.:|| ::..|::.:..|||
 Frog  1246 KEQL----------------ALNSQDGAGTF---NPDLIVSMAVEIERLKTEKASATMKRSAV-- 1289

  Fly   455 SSGPPPDQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPL 519
            .:..|.::|                .....:|.|:..:.           ....|...|..|:
 Frog  1290 VNEQPEEET----------------SKRHCNWNSSGDVG-----------EPEKHGTKQKPHV-- 1325

  Fly   520 RANRDLG------------------AQLADKICELQEAQEKL-KERERIH--------------- 550
             ..::||                  ::||.::.:.||.|:|| |....:|
 Frog  1326 -VQKELGSDWQENEANLEVQTMQLRSELAQRVRQNQELQDKLVKSEATVHAQTDQLKQYRGLLNE 1389

  Fly   551 ---EQACRTIQKLMQKLSSQ-----EKEIKKLNQENEQSANKENDCAKTVIS-------PSS--- 597
               ||..:.:|...|.|..:     |.|:     :.|:|.:.|.:..:.:.|       |||
 Frog  1390 SLVEQDSKQVQVDFQDLGYETCGRSENEV-----DREESTSPEYEEHEELFSENSLMEEPSSPYK 1449

  Fly   598 ------SGRSMSDNEASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQNLVNK----- 651
                  :...:.:||....:.:.:.....::.:.:|.  :|.|:.:::|....:.||.::
 Frog  1450 GWSPLVTSSPLKNNECGQNDWTLDWEKSEDVTVLQQH--VKNLKVQLQKAQKVISNLQSRARSFS 1512

  Fly   652 -----------------------------ELWEKNREVERLTKLLANQQKTLPQISEE-SAGEAD 686
                                         |.|:.:       .:..|..|.|.|:.:. |..||.
 Frog  1513 ASSDYANHHRLKHSVSFHGSTSHSITDEDEGWQSD-------TVGVNSTKDLEQLVQRVSMLEAQ 1570

  Fly   687 LQQSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLEC 751
            |.||..:......: ::.....|.|.|.|..|.:      :..||.:|::.|:
 Frog  1571 LHQSHRDVGAQDQI-KSATWPGKYDSLIQAQARE------LSLLRQKLREGRS------------ 1616

  Fly   752 VDVCSVLTNRLEELAGFLNSLLKHKDV-------------LGVLAADRRNAMRKAVDRS------ 797
              ||.:||..|.:.......||:..|:             .|...|:|.|....:.:||
 Frog  1617 --VCHILTQHLGDTIKSFEELLRANDIDYYMGQGFREQLTQGTQLAERLNNKLNSKERSDVDDKS 1679

  Fly   798 ------LDLSKSLNMTLNIT------------------ATSLADQSLA-------QLCN------ 825
                  :.|||.|.....|.                  |.|.:|||..       ||.|
 Frog  1680 RHELLAIRLSKELQQKDKIIESLQSKLEGHSLTPSSSHAISESDQSDRTSFVSDDQLSNNDDLDG 1744

  Fly   826 ---------------LSEILYTEGDASH----KTFNSHE-----ELHAATSMAPTVENLKA---- 862
                           :::.::.:..|||    ....|||     :||..::...:.|.|:.
 Frog  1745 CSEVATASDYTRSTHVADAIHIDNVASHPAKPSLSTSHEVQQQPKLHVKSAQPHSAETLQGHFIP 1809

  Fly   863 -----------------------------------------ENKALKKELEKRRSSEGQRKERRS 886
                                                     |...|:|:|.:            |
 Frog  1810 PPSSVNVLSAALPPSAPFPPFGAHPPMVSGPPVFSLAEVQQELHILQKQLAE------------S 1862

  Fly   887 LPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPE---QAISESESEGRTCATR---- 944
            :|:.|...              :.:.|.....:|:.|...|.   |.:.:..|   |.||:
 Frog  1863 MPMASSAI--------------RPAHASTSFFDTTTSSVFPSYFPQPLHDIPS---TTATQNAPG 1910

  Fly   945 ----QDRNRNSERIAQLEEQIAQKDERMLNVQCQMVELDNRYKQ-EQLRCLDITQQ-LEQLRAIN 1003
                :....||..:..::..:...:.   ||........:.|:. .:|...|:.:: |.::|.:.
 Frog  1911 FRAAETGFSNSSGLWDMQHLVRPVNG---NVHGDASSGSSGYQSASKLTGSDLLEEHLAEIRNLR 1972

  Fly  1004 EALTADLHAIGSHEEERMVELQRQLELKNQQIDQLKLA------------HS-----TLTADSQI 1051
            ::|...:|.     .:|   |:.|||      |:|..|            |.     .|:.:::.
 Frog  1973 QSLEESIHM-----NDR---LRAQLE------DKLTAATKGSGPPTNIYIHGLESLPQLSNENRA 2023

  Fly  1052 TEMELQALQQQMQEIEQLHADSVETLQ-------SQLQKLKLDAVQQLEEHERLHREALERDWVA 1109
            ...|..:||.::.:|.:.:...:|.||       :||:.::.|..|:.:|.::|..|
 Frog  2024 LREENLSLQVRINQISRDYFKELENLQKLLSSSRAQLKNVETDLEQKTQESKKLQEE-------- 2080

  Fly  1110 LTTYQEQAQQLLELQRSLDYHQENEKELKQ--TLVENELATRALKKQLDE-----STLQASKAVM 1167
               ..::.|::|.||:....:||....|:.  ||:|         :||:|     :::|:...|.
 Frog  2081 ---LDQKQQEILHLQKERQSNQEKSNRLQHQATLLE---------QQLNENCQLVNSMQSELQVY 2133

  Fly  1168 ERTKAYNDKLQLEKRS-------------EELRLQLEALKEEHQKLLQK----RSNSSDVSQSGY 1215
            ||... :.||.|...|             .||..::.:|:.:.:|.:|.    |.|.....:..:
 Frog  2134 ERLYG-SSKLVLSAFSGETYHSLPANYDFSELLSEVRSLRSQMEKSIQVNTSIRHNLEKQLEGSF 2197

  Fly  1216 TSEEVAVPMGPPS-GQATTCKQAAAAVLGQRVNTSSP--DLGIESDAGRISSVEVSNAQR----- 1272
            .:.|    |.|.| .....|:..|...|.|....|.|  |:|:.|.:....|....||..
 Frog  2198 GANE----MRPSSINIFPLCEHTAKKQLFQDPIPSPPVRDVGMHSPSTFFPSSSFLNASHTAPVL 2258

  Fly  1273 --AMLKTVEMKTEGSASPKAKSE--ESTSPD---------------------------------- 1299
              ::|...:..:..|||.::|||  |..:||
 Frog  2259 DLSLLNKAQEASCNSASGESKSEKLEGDAPDGSFANKNGRHVIGHIDDFTALKQQILEGKMLIQK 2323

  Fly  1300 ------SKSNVA-------------------TGAATVHDCAK----------------------- 1316
                  |..|:|                   :..:|:|...|
 Frog  2324 METIMQSSLNIAFLEIHGTKALDYGSIKRLFSTTSTLHQILKESASLLGMFWRAALPNTQSATQQ 2388

  Fly  1317 ------VDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNME 1375
                  :..|..:|:.||...:.|.::..|.|:..|:||..:|..|.:|:.:||:||:..|||:|
 Frog  2389 KKEEQAMKEEICQLKNKLKEQEVALQEAKEHLKSTNRAKESMEHFIVSQLTRTHDVLKKTRSNLE 2453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:462333	24/136 (18%)
		Smc	<138..>404	CDD:440809	72/372 (19%)
		SMC_prok_B	498..1200	CDD:274008	169/976 (17%)
		Smc	<929..>1247	CDD:440809	76/376 (20%)
pde4dip	XP_031756145.1	SMYLE_N	1..388	CDD:465822
		Smc	<390..1020	CDD:440809	65/354 (18%)
		SMC_prok_B	<533..822	CDD:274008	31/150 (21%)
		SMC_N	669..1443	CDD:481474	149/837 (18%)
		EnvC	<1959..>2118	CDD:443969	41/192 (21%)
		EnvC	2044..>2194	CDD:443969	38/170 (22%)