Protein Alignment cnn and cdk5rap2

DIOPT Version :10

• Sequence 1: NP_001246293.1
• Gene: cnn / 36491
• FlyBaseID: FBgn0013765
• Length: 1378
• Species: Drosophila melanogaster
• Sequence 2: NP_001039129.1
• Gene: cdk5rap2 / 733952
• XenbaseID: XB-GENE-5725315
• Length: 859
• Species: Xenopus tropicalis
• Alignment Length: 1197
• Identity: 245/1197 - (20%)
• Similarity: 432/1197 - (36%)
• Gaps: 437/1197 - (36%)

  Fly   100 VRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAKIEIATLRKTVDVKMEL 164
            :::.|:|::.|:||||||||||||||| |...:.|||.|.|.:..|:.|:|..||:..:..|..|
 Frog     1 MKDFEKQIADLKKENFNLKLRIYFLEE-QVQQKCDSSNEDLYRMNIELKVESETLKHDLQEKQHL 64

  Fly   165 LKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTRKMLRLESEVQRL 229
            |..|::|:                                      ||:|
 Frog    65 LIKASKAL--------------------------------------ENLA--------------- 76

  Fly   230 EEELVNIEARNVAARNELEFMLAERLESLTACEGKIQELAIKNSELVERLEKETASAESSNEAID 294
                           .|.||.:.:..|.   |...:|.|..:.:..:..||||.|:|   ||..|
 Frog    77 ---------------GENEFKMIQVKED---CNKNLQSLEYELNRKISVLEKEVATA---NEEAD 120

  Fly   295 SLKVELEACRK-----ENQDLVTSI-----RTLKHDMKRQVRSMKEAANTMDVQRQSILLLEATI 349
            .:...|:..||     ||:.|..||     ||:::: .|.:.|           ::|.:.||:.|
 Frog   121 KIAQLLDQERKQRSALENKPLAVSILCERGRTIENE-NRYLNS-----------KESSVSLESQI 173

  Fly   350 KRKEKSCGSMQKNVLNYEALIAKLNAELETMRQQNVYFRELSENLQQKEVRQLDRGVAIVQPMRM 414
                        :|.||  ||.|.:..::.:.    :..|.|             ||.:||
 Frog   174 ------------SVTNY--LIQKDDLGMDLLS----FSHEKS-------------GVDLVQ---- 203

  Fly   415 TADAGRFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDRAKYGLLQL 479
                                          :::|..|..::|.                   ||:
 Frog   204 ------------------------------NDISEDAHNVASD-------------------LQI 219

  Fly   480 FAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLRANRDLGAQLADKICELQEAQEKLK 544
               |||          |:..||                                   .|.|::|:
 Frog   220 ---KLD----------HMEKKI-----------------------------------SELQQELR 236

  Fly   545 ERE---RIHEQAC----RTIQKLMQKLSSQEKEIKKLNQENEQSANKENDCAKTVISPSSSGRSM 602
            |:|   .:||:..    :|||.|...|.::|||.::.........|.:.|       .|.|..:.
 Frog   237 EKETELALHEENAVKRDKTIQGLTLALKNREKEEQRKTYLRTSFLNVKED-------KSYSQFTK 294

  Fly   603 SDN-EASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKK------KTA----------------- 643
            |:| |...:|.::..::..|::.|:|:..:  ||.|:.|      :||
 Frog   295 SENSEGHQKEFNSQNKLEKEIQCNQQQSTV--LQEEINKSKFENDETASFFGDATSYLSICLDPS 357

  Fly   644 --------NLQNLVN------KELWEKNREVERLT------KLLANQQKTLPQISEESAGEADLQ 688
                    :|||:|.      ||: :|:..:|::|      |...|...|:.:.:::|.
 Frog   358 SGDQLSVEDLQNMVAQLMNKIKEM-QKSPGLEKVTECSCHFKSTDNNSSTISKFAKKSK------ 415

  Fly   689 QSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQLRLELQQARTEVETADKWRLECVD 753
                    :..|.:..|..:|:..|:.|.|:              :...:.|::|. |:..:||:
 Frog   416 --------IPVLRKKPLCIKKIPELYSRTAN--------------VTAPQEELQTC-KFENDCVE 457

  Fly   754 VCSVLTNRL-------EELAGFLNSLLKHKDVLGVLAADRRNAMRKAVD---RSLDLSKSLNMTL 808
            ....|:|.|       |.|..  |.:|..::.|..||    |.::...|   :|.|:.|::..:.
 Frog   458 NDECLSNELWHAHEEREHLKA--NKILVKEEHLVPLA----NGIKAQSDHCEQSFDMEKTITNSS 516

  Fly   809 NITATSLADQSLAQLC------NLSEILYTEGDA---SHKTFNSHEELHAATSMAPTVENLKAEN 864
            :..|....:.:..:||      |..::|....|.   ...|.|..|.||...:..|.:||....|
 Frog   517 SFVANDEINNAEQELCAMHYEKNAEDVLELVTDCYDNCTNTKNEMEFLHNLGAETPKIENNSPVN 581

  Fly   865 KALKKELEKRRSSEGQRKERRSLPLPSQ-QFDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPE 928
            :...::.    |:|           ||. ::|...:::|     |::|:.|
 Frog   582 ECTLEDF----SNE-----------PSHARYDLLVQAQA-----RELSVQR-------------- 612

  Fly   929 QAISESESEGRTCATRQDRNRNSERIAQLEEQIAQKDERMLNVQCQMVELDNRYKQEQLRCLDIT 993
            |.|.||......|      .:|..::.:..:::.:..:            .:.|..|..:. .:.
 Frog   613 QKIKESHILSVIC------YKNCIKVLKAFDELLEASD------------VDYYVAESFQA-HLN 658

  Fly   994 QQLEQLRAINEALTADLHAIGSHEEERMVELQRQLELKNQQIDQ-----LKLAHSTLTADSQITE 1053
            |.|:.::.:...|..|..|...|...:.......|...:.:.|:     |.||.......:||
 Frog   659 QFLQWIKNVEYKLGYDEDAYSEHSANKSYNPSCLLPGHDMRGDESGSPVLGLAEGYCAILNQI-- 721

  Fly  1054 MELQALQQQMQEI--EQLHADSVETLQSQLQKL---KLDAVQQ-LEEHERLHREALERDW-VALT 1111
            ::...|.|:|:..  ..:|:.::: :..:.||.   ||...|| ||:    .|..::|.| |.|.
 Frog   722 LDGGDLLQEMENYLDHSVHSSAIQ-VTDEFQKYFYEKLHRTQQSLED----ARHMMKRHWRVPLP 781

  Fly  1112 TYQEQAQQLLELQRSLDYHQENEKEL----KQTLVENELATRA--LKKQLDESTLQASKAVMERT 1170
            .....:|.:.|       .:|:.||:    .:.|.:|..:...  |:||..|.|   .|::::..
 Frog   782 NDLNHSQAIYE-------GEESNKEMFRLQNKVLEDNPFSVEGFYLEKQAVEET---DKSILDHL 836

  Fly  1171 KAYNDKLQLEKRSEELRLQLEALKEEH 1197
             |...|:....||   .|:::.:|:.|
 Frog   837 -ALTYKVLKTARS---NLEMQVIKKNH 859

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:462333	33/68 (49%)
		Smc	<138..>404	CDD:440809	55/275 (20%)
		SMC_prok_B	498..1200	CDD:274008	155/789 (20%)
		Smc	<929..>1247	CDD:440809	58/287 (20%)
cdk5rap2	NP_001039129.1	Cnn_1N	2..70	CDD:462333	33/68 (49%)
		PRK05771	19..>297	CDD:235600	103/503 (20%)