Protein Alignment cnn and Pde4dip

DIOPT Version :9

• Sequence 1: NP_001246293.1
• Gene: cnn / 36491
• FlyBaseID: FBgn0013765
• Length: 1378
• Species: Drosophila melanogaster
• Sequence 2: XP_017446558.1
• Gene: Pde4dip / 64183
• RGDID: 708410
• Length: 2587
• Species: Rattus norvegicus
• Alignment Length: 1678
• Identity: 357/1678 - (21%)
• Similarity: 621/1678 - (37%)
• Gaps: 559/1678 - (33%)

  Fly    30 ETVTS-------FLEENGAAEIDRRVLRKLAEALSKSIDDTSPGALQDV---------TMENSYA 78
            |.|:|       |.||:|  |:..|...  |.|......|..|.....|         ...:|..
  Rat   126 EAVSSAPWMRHYFGEEDG--EMVPRTSN--AAAFLSDTKDRGPPVQSQVWRSAEKVPFGQAHSLR 186

  Fly    79 SFDVPRPPGGGNSPLPSQGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQ 143
            :|:.|        || .|.:::|:.|:.::.|:||||:|||||||||| :...:.:.|.|.:.|:
  Rat   187 AFEKP--------PL-VQTQALRDFEKHLNDLKKENFSLKLRIYFLEE-RMQQKYEVSREDVYKR 241

  Fly   144 LIDAKIEIATLRKTV-DVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQI-HAYQMAESG 206
            .|:.|:|:.:|::.: |.|..|.|..|    ..|:|..:.:.:.:..::|.|::. |.|::.::.
  Rat   242 NIELKVEVESLKRELQDRKQHLHKTWA----DEEDLNSQNEAELRRQVEEPQQETEHVYELLDNN 302

  Fly   207 GQ--------------PVENIAKTRKMLRLESEVQRLEEELVNIE---------ARNVAARNELE 248
            .|              .:|.:.:..|...||.. :|.::...|.|         .:..||..:.:
  Rat   303 IQLLQEESRFAKDEATQMETLVEAEKGCNLELS-ERWKDATKNREDAPGDQVKLDQYSAALAQRD 366

  Fly   249 FMLAERLESLTACEGKIQELAIKNSELVERLEK----------------------ETASAESSNE 291
            ..:.|..:||.|.||.:::|:.:..:|:..||:                      ||.:.:.|
  Rat   367 RRIEELRQSLAAQEGLVEQLSREKQQLLHLLEEPGGMEVQPMPKGLPTQQKPDLNETPTTQPS-- 429

  Fly   292 AIDSLKVELEACRKENQDLVTS--IRTLKHDMKRQVRSMKEAANTMDVQRQSILLLEATIKRKEK 354
            ..||...||:  .|..|..||:  ::...:||..::||.:|::...|...||   |:..:|.:|.
  Rat   430 VSDSHLAELQ--DKIQQTEVTNKILQEKLNDMSCELRSAQESSQKQDTTIQS---LKEMLKSRES 489

  Fly   355 SCGSMQKNVLNYEALIAKLNAELETMR-------------QQNVYFRELSENL--QQKEVRQLDR 404
            ....:.:.:......:|||...|...:             ||.|...:|...|  .|.|:::|.|
  Rat   490 ETEELYQVIEGQNDTMAKLREMLHQSQLGQLQSSEGIAPAQQQVALLDLQSALFCSQLEIQKLQR 554

  Fly   405 GVAIVQPMRMTADAGRFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGH 469
              .:.|..|..|| |:...|.....|||   .|:|..||..                       |
  Rat   555 --LLRQKERQLAD-GKRCMQFVEAAAQE---REQQKEAAWK-----------------------H 590

  Fly   470 DRAKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLRANR----------- 523
            ::                 .:..||.|       |...|||..|.:|: |.|.:
  Rat   591 NQ-----------------ELRKALQH-------LQGELHSKSQQLHV-LEAEKYNEIRTQGQNI 630

  Fly   524 -DLGAQLADKICELQEAQEKL------------------KERERIHEQACRTIQKLMQKLSSQEK 569
             .|...|:.|...:||.||.|                  |.|:||.::|....:.:.:|.|:.|:
  Rat   631 QHLSHSLSHKEQLIQELQELLQYRDTTDKTLDTNEVFLEKLRQRIQDRAVALERVIDEKFSALEE 695

  Fly   570 EIKKLNQENEQSANKEND-----CAKTVISPSSSGRSMSDNEASSQEMSTNLRVRYELKINEQEE 629
            :.|:|.|......::::|     |.            :|.|||:.|.|.:.||.|
  Rat   696 KDKELRQLRLAVRDRDHDLERLRCV------------LSANEATMQSMESLLRAR---------- 738

  Fly   630 KIKQLQTEVKKKTANLQNL--VNKEL------WEKNRE--VERLTKLLANQQKTLPQISEESAGE 684
                 ..||::.||..|||  :.:||      |:|.:|  :::|...|.::.|.:..:|
  Rat   739 -----GLEVEQLTATCQNLQWLKEELETKFGHWQKEQESIIQQLQTSLHDRNKEVEDLS------ 792

  Fly   685 ADLQQSFTEAEYMRALERNKLLQRKVDVLFQRLADDQQNSAVIGQLRLELQQARTEVETADKWRL 749
            |.|.......:...|.|..:.||||..|| |.|..|:...|:..::
  Rat   793 ATLLHKLGPGQSEVAEELCQRLQRKERVL-QDLLSDRNKQAMEHEM------------------- 837

  Fly   750 ECVDVCSVLTNRLEELAGFLNSLLKHKDVLGVLAADRRNAMRKAVDRSLDLSKSLNMTLNITATS 814
                          |:.|.|.|       :|....:|:....|.|...::.:..|
  Rat   838 --------------EVQGLLQS-------MGTREQERQAVAEKMVQAFMERNSEL---------- 871

  Fly   815 LADQSLAQLCNLSEILYTEGDASHKTFNSHEELHAATSMAPTVENLKAENKALKKELEKRRSSEG 879
               |:|.|.....|::     |:.:.|.|::.. .|||:.|                     ..|
  Rat   872 ---QALRQYLGGKELM-----AASQAFISNQPA-GATSVGP---------------------HHG 906

  Fly   880 QRKERRSLPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPEQAISESESEGRTCATR 944
            ::.::.|..:||:  |:.:...|..|    .|:.|..|.: |:::|..|:.:|.::.|....|.:
  Rat   907 EQTDQGSTQMPSR--DDSTSLTAREE----ASIPRSTLGD-SDTVAGLEKELSNAKEELELMAKK 964

  Fly   945 QDRNRNSE-RIAQLEEQIAQKDERMLNVQCQMVELDNRYKQEQLR---CLDITQQL---EQLRAI 1002
            :   |.|: .::.|:..:|.::|.:   |.|..:|::..:..|::   ..|:..||   |.:.|:
  Rat   965 E---RESQIELSALQSMMAVQEEEL---QVQAADLESLTRNIQIKEDLIKDLQMQLVDPEDMPAM 1023

  Fly  1003 NEALTADLHAIGSHEEERMVELQRQLELKNQQIDQLKLAHSTLTADSQITEMELQALQQQMQEIE 1067
             |.||.::..:  .|:...||.|.|...:|::...|.:....:...|::.| .|||.:|....:.
  Rat  1024 -ERLTQEVLLL--REKVASVEPQGQEGSENRRQQLLLMLEGLVDERSRLNE-ALQAERQLYSSLV 1084

  Fly  1068 QLHA---------------DSVETLQSQLQKL---KLDAVQQLE--------------------- 1093
            :.||               :..:.|:|:|:::   .|:.:.:||
  Rat  1085 KFHAQPETSERDRTLQVELEGAQVLRSRLEEVLGRSLERLSRLETLAAIGGATAGDETEDTSTQF 1149

  Fly  1094 -----------EHERLHREALERDWVALTTYQEQ------------------AQQLLELQRSLDY 1129
                       .|::|.:.:||:   :|||.:.|                  .:::|.|:..:..
  Rat  1150 TDSIEEEAAHNSHQQLIKVSLEK---SLTTMETQNTCLQPPSPVGEDGNRHLQEEMLHLRAEIHQ 1211

  Fly  1130 HQENE-------KELK---------------QTLVENELATRALKKQ------------------ 1154
            |.|.:       ||||               .|::...|....||:|
  Rat  1212 HLEEKRKAEAELKELKAQIEEAGFSSVSHIRNTMLSLCLENAELKEQMGEAMSDGWEVEEDKEKG 1276

  Fly  1155 ------------LDESTLQAS-KAVMERTK-AYND----KLQLEKRSEE----------LRLQLE 1191
                        |.|.:|||. :.|..|.| |||.    |.||..||.|          :||..|
  Rat  1277 EVMVETVVAKGGLSEDSLQAEFRKVQGRLKSAYNIINLLKEQLVLRSSEGNTKEMPEFLVRLARE 1341

  Fly  1192 A--------LKEEHQKLLQKR-------------------------SNSSDVSQSGYTSEEVAVP 1223
            .        ..|:||...|:.                         .|.|....||: ..:.::|
  Rat  1342 VDRMNMGLPSSEKHQHQEQENMTARPGPRPQSLKLGTALSVDGYQLENKSQAQDSGH-QPQFSLP 1405

  Fly  1224 MGPP--SGQATTCKQ-----------AAAAVLGQRVNTSSPDLGIESDAGRISSVEVSNAQ-RAM 1274
            ....  ..|...|:|           :.|.|..| .|.......|.|:    |.|:..:.| :..
  Rat  1406 GSTKHLRSQLAQCRQRYQDLQEKLLISEATVFAQ-ANQLEKYRAILSE----SLVKQDSKQIQVD 1465

  Fly  1275 LKTVEMKTEGSASPKAKSEESTSPDSKSN-------VATGAAT---------VHDCAKVDLENAE 1323
            |:.:..:|.|.:..:|:.||:|||:.:.:       :..|..:         |....|..|||..
  Rat  1466 LQDLGYETCGRSENEAEREETTSPECEEHGNLRPVVLVEGLCSEQGYLDPVLVSSPVKKPLENKP 1530

  Fly  1324 LRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNMEN 1376
            .:|:..:.:...:|: ..||       :..:|:|.|:...:.|::|:||.:.:
  Rat  1531 GKREEFQAQGTSDDS-SLLR-------KDIRDLKAQLQNAYKVIQNLRSRVRS 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:285263	28/69 (41%)
		HMMR_N	891..1203	CDD:292527	95/462 (21%)
		FAM76	<1019..1087	CDD:292665	17/85 (20%)
Pde4dip	XP_017446558.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10737
eggNOG	1	0.900	-	-		E1_2BXW1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4301
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46501
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.050