DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnn and si:ch211-242b18.1

DIOPT Version :9

Sequence 1:	NP_001246293.1	Gene:	cnn / 36491	FlyBaseID:	FBgn0013765	Length:	1378	Species:	Drosophila melanogaster
Sequence 2:	XP_005160852.1	Gene:	si:ch211-242b18.1 / 566905	ZFINID:	ZDB-GENE-030131-1518	Length:	2239	Species:	Danio rerio

Alignment Length:	1533	Identity:	314/1533 - (20%)
Similarity:	549/1533 - (35%)	Gaps:	494/1533 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RVLRKLAEALSKSIDDTSPGALQDVTMENSYASFDVPRPPGGGNSPLPSQGRSVRELEEQMSALR 111
            :|.||:..:.|........|::||.|.|.      ||..|    .|.|.:.....||:
Zfish   197 KVPRKVGRSTSCGPSTRYSGSVQDNTEET------VPSAP----PPEPIENNQSCELK------- 244

  Fly   112 KENFNLKLRIYFLEEGQPGARADSSTESLSK------------QLIDAKIEIATLRKT------- 157
                            ..|....||.|||..            .|::::.|.:.:|:.
Zfish   245 ----------------PVGVSPASSVESLDTAVDVTQESYLKLPLLESEEEQSVVRRPESKPGSV 293

  Fly   158 --VDVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTRKML 220
              :||.:.|||...   .|..:.||.:.|.               .:.::...|:|:.....::.
Zfish   294 CGLDVALSLLKSCE---YHPLQSQRGSRIP---------------VLLKTNTTPMESPYPLLQVP 340

  Fly   221 RLESEVQRLEEELVNIEARNVAARNELEFMLAER----LESLTACEGKIQELAIKNSELVERL-- 279
            .:|.|.. |..:|.::.:   :.:.||:..|||.    |:....|         |.|.|.:||
Zfish   341 HIEMECP-LFPQLPDVPS---SIQQELQLELAEMEDQWLDDYVQC---------KPSGLPKRLIE 392

  Fly   280 EKETASAESSNEAIDSLKVELEACRKENQDLVTSIRTLK----------HDMKRQVRSMKEAANT 334
            |::...||..|.|...:. ||:..:::.|.|.|.||..:          .||:.::||::|||..
Zfish   393 EQQCHLAEYENAAGQCVN-ELQKAQQQVQSLQTKIRDSEASNKKLQQKLRDMENELRSVREAACG 456

  Fly   335 MDVQRQSILLLEATIKRKEKSCGSMQKNVLNYEALIAKLNAELETMRQQNVYFRELSENLQQKEV 399
               |..:|..|..::..|:.....:|:.:...:.|:..|       :|||.:::     |||::
Zfish   457 ---QETTIQTLGDSLSTKDYEITDLQRVIEEQKELLCSL-------KQQNNHYQ-----LQQQQ- 505

  Fly   400 RQLDRGVAIVQPMRMTADAGRFVWQSGTIVAQEPLP----LERQSAAATSNVSVSAVRLSSGPPP 460
                  |:.|.|..:.||.  ...|.....||..|.    .::||.....:::.:..||.:
Zfish   506 ------VSGVTPSHLQADL--LDLQGSLFSAQLELQGLQRTQQQSQRREDDLTRANQRLQT---- 558

  Fly   461 DQTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLRANRDL 525
            |....|..|..|:                                              :.|:||
Zfish   559 DLQGAVQRHREAE----------------------------------------------KHNQDL 577

  Fly   526 GAQLADKICELQEAQEKL----KERERIHEQACRTIQKLMQKLSSQEKEIKKLNQ----ENEQSA 582
            ...|.....:|.:.:||.    ::||...|:..:||::|...|..:|:.::..::    :.|.:.
Zfish   578 LTALESARAKLLQTEEKWRDEGRQRENEVEEREKTIRELKTSLEHKERLVQDYSELVDGQKEPAG 642

  Fly   583 NKENDCAKTVISPSSSGRSMSDNEASSQEMSTNLRVR---YELKINEQEEKIKQLQTEVKKKTAN 644
            |::|                     ..|::...::.|   .|..::|:...::|.:.|::|
Zfish   643 NRDN---------------------LIQKLKQRIQERDRALERAVDEKFTCMEQKEDEMRK---- 682

  Fly   645 LQNLVNKELWEKNREVERLTKLLANQQKTLPQISEESAGEA-DLQQ------------SFTEAEY 696
            ||.|    |.||.|::|:|..:|:|.::|:..:.....|:. :|:|            |..|..|
Zfish   683 LQLL----LREKERDLEKLRCVLSNNEETIMSLEMLLRGKGLELEQVCEAWRSAQGVHSEREESY 743

  Fly   697 MRAL-ERNKLLQRKVDVLFQRLADDQQNSAVI--------GQL------RLELQQARTEVETADK 746
            ||:| ||:.|:.:....|..|..:.::.:||:        |::      ||:|::...:...:|:
Zfish   744 MRSLRERDALISQLQTSLHTRTKEAEEMTAVLLSKVSVGAGEVAEELKSRLQLKERLFQELLSDR 808

  Fly   747 WR------------LECV---------------DVCSVLTNRLEEL---AGFLNSLLKHKDVLGV 781
            .|            |..:               .|.:..|.||:||   .|..|..|..:|...:
Zfish   809 SRQTQEHHSQVQDLLNTISSREHYIKDSAGRVGQVMAEQTARLQELRKQLGSANPELTQEDTQAL 873

  Fly   782 LAADRRNAMRKAVDRSLDLSKSLNMTLNITATSLADQSLAQLCNLSEILYTEGDASHKTFNSHEE 846
            :     :.::..:.|..:....|:: |..|..|..||...|..:|        ||..:|.:..||
Zfish   874 M-----DELQMTLRREREAQTQLSI-LRATLASYQDQLQTQTSDL--------DALSRTASVKEE 924

  Fly   847 LHAATSM-------APTVENLKAENKALKKELEKRRSSEGQRKERRSLPLPSQQ----------- 893
            :.....|       .|.||.|..|.:.|::::|.:.:|....|:....||.|.:
Zfish   925 IIKDLQMQLVEPSDLPLVERLTQELQLLREKVESQEASCNNHKQALLDPLVSMETGQAVQPHADF 989

  Fly   894 --FDNQSESEAWSEPDRKVSLARIGLDETSNSLAAPEQAISESESEGRTCATRQDRNRNSERIAQ 956
              |.:....|...|.|.....|..|.||                             :.|:|.||
Zfish   990 GGFTSDDGEEEEDEEDCNSEFAGSGEDE-----------------------------KRSKRTAQ 1025

  Fly   957 LEEQIAQKDERMLNVQCQMVELDNRYKQEQLR-CLD----------ITQQLEQLRAINEALTADL 1010
                             .:|.|.:..:.:.|| |.|          :.|.:||.||:
Zfish  1026 -----------------SLVSLQSCDQHQGLRGCQDAVAEGPGLAEVKQLVEQKRAV-------- 1065

  Fly  1011 HAIGSHEEERMVELQRQLELKN-QQIDQLKLAHSTLTADSQITE--MELQALQQQMQEIEQLHAD 1072
                   |..::||:.|||... ..:.|::.|..||.:.::..:  |.||.:.|:.....|| .|
Zfish  1066 -------ERELMELKSQLEKAGFSSLSQMRKAFFTLRSQNEELKGLMNLQNVGQKSTSCGQL-VD 1122

  Fly  1073 SV-------ETLQSQLQKLKLDAVQQLEEHERLHREALERDWVALTTYQEQAQQLLELQ------ 1124
            :|       |:.:.|..:||.|..|..:|    .||..||..|:..|.|.||:||.:.:
Zfish  1123 TVGAKGKERESAREQTVQLKSDLAQVQQE----SRELQERLMVSEATVQAQAEQLKDYRELLTET 1183

  Fly  1125 -------------RSLDY----HQENEKELKQT----LVENELATRALKKQLDESTLQASKAVME 1168
                         :.|.|    ..|||.|.:.|    ..:.||.| :|..:...|...|..|...
Zfish  1184 SVQQDSKQVQVDIQDLGYETCGRSENEAEREDTSSPEFDDLELCT-SLSYRDAGSQWWAGPATHN 1247

  Fly  1169 RTKAYNDKLQLEKRSEELRLQLEALKEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATT 1233
            ..|..:|...|::..|:||.||              |.|..:.:|.........|:|.|
Zfish  1248 SGKPEHDVTYLQQLVEDLRGQL--------------SRSQALIRSLQAQMRDCTPVGTP------ 1292

  Fly  1234 CKQAAAAVLGQRVN----------TSSPDLGIESDAGRISSVEVSNAQRAMLKTVEMKTEGSASP 1288
                      ::||          |:..|.|.:|..|..|........|.:.:.|...|  |...
Zfish  1293 ----------RKVNWGLDNSETQSTAEEDEGWQSSDGFGSLPRQPKQDRELQELVSRVT--SLEE 1345

  Fly  1289 KAKSEESTSPDSKSNVATGAATVHDCAKVDL-------ENAELRRKL--------IRTKRAFE-- 1336
            :.:..:..:.|.|:....|        |.|.       |.:.||:|:        |.|:...:
Zfish  1346 QLRKGKGHADDGKNGNWPG--------KFDTLIQAQARELSHLRQKMREGRGMCHILTQHLGDTT 1402

  Fly  1337 DTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNM 1374
            .|:|:|..:|.....:.:..::|:.::.::.:.|.:.:
Zfish  1403 KTFEELLRSNDIDYYMGQSFRDQLSQSISLAQRVSTKI 1440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:285263	16/89 (18%)
		HMMR_N	891..1203	CDD:292527	82/372 (22%)
		FAM76	<1019..1087	CDD:292665	21/77 (27%)
si:ch211-242b18.1	XP_005160852.1	zf-AD	10..84	CDD:285071
		Apolipoprotein	766..959	CDD:279749	41/206 (20%)
		SMC_prok_B	810..>1486	CDD:274008	155/752 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BXW1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46501
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.000