Protein Alignment cnn and cdk5rap2

DIOPT Version :10

• Sequence 1: NP_001246293.1
• Gene: cnn / 36491
• FlyBaseID: FBgn0013765
• Length: 1378
• Species: Drosophila melanogaster
• Sequence 2: XP_009293383.1
• Gene: cdk5rap2 / 334460
• ZFINID: ZDB-GENE-030131-6392
• Length: 2913
• Species: Danio rerio
• Alignment Length: 1565
• Identity: 325/1565 - (20%)
• Similarity: 580/1565 - (37%)
• Gaps: 425/1565 - (27%)

  Fly    17 GTCASSLKEITLIETVTSFLEENGAAEIDRRVLRKLAEALSKSID----------------DTSP 65
            |.|...|:.|...:.....|:|..||::.:  |.|..:.|...|.                |..|
Zfish    52 GKCVFLLERIVQCDVTIGQLQETHAAQLQQ--LEKERDGLKTQITNKYRQHNPTGSKLLKWDVQP 114

  Fly    66 GALQDVTMENSYASFDVPRPPGGGNSPLPSQGRSVREL-------EEQMS-ALR----------- 111
            ||.  :.......|...|:|.....|.:....|..|::       |::.: :||
Zfish   115 GAC--LYTPKQLQSMQCPQPKQSQISDIQETTRRNRKVVSANLGCEKKFAGSLRRCVSLEPLCKV 177

  Fly   112 ------KENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAKIEIATLRKTVDVKMELLKDAAR 170
                  :...|.:|:...:...:|        .|||:..:|...:.::|.:::.::...|::...
Zfish   178 GTDRSHRSKLNSRLKAADVPAPRP--------RSLSRDYLDVVNKKSSLSRSISLQSVALENTDH 234

  Fly   171 AISHHEELQR---KADIDSQAIIDELQEQIHAYQ----MAESGG-------QPVENIAKTRK--- 218
            |:.......|   .|.::..:::.::.:.:...|    :...||       .|:.:.|.|.|
Zfish   235 ALIRQTRPFRGSTPAAVEKTSLVFDILQLLKIVQGVRFVPRCGGSRIPVLKHPLHSHANTHKGGV 299

  Fly   219 --MLRLESEVQRLEEELVNIEARNVAARNELEFMLAERLESLTACEGKIQELAIKNSELVERLEK 281
              ..|:|..::.:|:|. |.:.|.:            :.|.:...:.::..|..|..:|.|.|.|
Zfish   300 SWKSRVERNLREMEDEF-NDDYRPL------------KREIIVDRQNELSRLEQKTRQLTEELNK 351

  Fly   282 ETASAESSNEAIDSLKVELEACRKENQDLVTSIRTLKHDMKRQVRSMKEAANTM--DVQRQSILL 344
            ...:.::..:|:|.::.|.:|...|.|             ||::....|..|::  |...|.:.|
Zfish   352 AKNNGQTLKDALDEMEKEKKALSDELQ-------------KREIELSTEKKNSLKRDKAIQGLTL 403

  Fly   345 LEATIKRKEKSCGSMQKNVLNYEALIAKLNAELETMRQQNVYFRELSENLQQKEVRQLDRGVAIV 409
            .   :|.|||....:..::...:..:||....|...:.|..:..|..::|..::..:|.
Zfish   404 F---LKEKEKEIEDLSGDLEEKDQALAKAREALHKAKLQKYHGAEDQQSLLLEQQAELS------ 459

  Fly   410 QPMRMTADAGRFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDRAKY 474
               |:.|:|     .|..:.||.   |:|...:..|.:|
Zfish   460 ---RLQAEA-----HSSLLEAQR---LQRVLGSRDSELS-------------------------- 487

  Fly   475 GLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLRANRDLGAQ-------LADK 532
             |||  .|||.                  |...|....|......:...||..|       |||:
Zfish   488 -LLQ--QAKLQ------------------LEQELEQLQQQKKKGDKTINDLQNQLKKLNGTLADR 531

  Fly   533 ICELQEAQEKLKERERIHEQACRTIQKLMQKLSSQEKEIKKLNQENEQSANKENDCAKTVISPSS 597
            ...|.  |::|:::|:|     |..::.||  ::.|:....||.:::|..:..|     ::....
Zfish   532 ENALD--QQRLEQQEQI-----RASEQKMQ--NAMERLTASLNHKDQQLQDYMN-----MVRDLE 582

  Fly   598 SGRSMSDNEASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQ------NLVNKELWEK 656
            ..||..:.:    .|...||.|.       :||.|.|:..:.:|.|.::      :|:...|.||
Zfish   583 KNRSQEEGD----PMLAKLRARL-------KEKEKALEKALDEKFAAVEEKENEIHLLQLSLREK 636

  Fly   657 NREVERLTKLLANQQKTLPQ----ISEESAGEADLQQSF------------TEAEYMRAL-ERNK 704
            .|:||||..||::.::|:..    |.|.   :.:|||..            ||....||| |::.
Zfish   637 ERDVERLNNLLSHNEETINSFDAVIKER---DLELQQLLNSLKNLQRSKDETEENLHRALREKDA 698

  Fly   705 LLQRKVDVLFQRLAD-DQQNSAVIGQ-------------LRLELQQARTEVETADKWRLECVDVC 755
            ::|.....|..:..| ::..:.|:.|             .||::.:|.......|:.||
Zfish   699 IIQHLQQALDNKTKDMEEMANRVLNQSESQGRDLAEQMSQRLKVTEAMLSEAVKDRERL------ 757

  Fly   756 SVLTNR--LEELAGFLNSLLKHKDVLGVLAADRRNAMRKAVDRS---LDLSKSLNMT-------- 807
             |..|:  :|.|...::|    ||.|  |............|||   |||.|.|:.|
Zfish   758 -VTENQTAVENLLATISS----KDQL--LKESMERHTHTLSDRSAEMLDLRKQLSDTQQQLRNAQ 815

  Fly   808 -LNITATSLADQSLAQLCNLSEILYTEGDA---------SHKTFNSHEELHAATSMAPTVENLKA 862
             ||..||......:|:|    ..:.:|.||         ..|..:...|:.:..:..|.|..|:.
Zfish   816 RLNAAATQDGHLEIAEL----RAMLSEKDALINKLLERGQEKDRSILFEMKSGEAPPPQVLELRQ 876

  Fly   863 ENKALKKELEKRRSSEGQRKERRSLPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSN----- 922
            ..:.|:::||:|.:...:|.....|.:     |..::..|       |.|.|..|.:|..
Zfish   877 TIELLQEKLEEREAELSRRNSEEMLDV-----DAVTKKSA-------VLLKRELLQKTDALNAAL 929

  Fly   923 --------SLAAPEQAISESES--EGRTC---ATRQDRNRNSERIAQLEEQIAQK-DERMLNVQC 973
                    |||..:.::||.|:  ||:|.   :.....|...|.|.:|..:::|: |.|:...:.
Zfish   930 KRENQLKISLAELQSSLSELEARLEGQTANIESLTSTLNTKEEIITELHHRLSQRGDSRVPLTRD 994

  Fly   974 QMVEL-DNRYKQEQLRCLDIT------QQLE-----QLRA----INEALTADLHAIGSHEEERMV 1022
            |..:| ::.|....|...:.|      |||:     .||:    :|.||.|:.|...
Zfish   995 QASQLGESEYSPSSLPQRETTIIGGDRQQLDVASLSDLRSEQAELNRALRAEQHLYS-------- 1051

  Fly  1023 ELQRQLELKNQQIDQLKLAHSTLTADSQITEMELQA---LQQQMQEIEQLHADSVETLQSQLQKL 1084
            :|.|.:: :...:::|           |:.::||.|   |:||::...|::::..:.||:::.:.
Zfish  1052 DLIRAVK-ERDSVERL-----------QVLQLELTAVALLRQQLESGVQMNSELRDQLQTEIHRT 1104

  Fly  1085 KLDAVQQLEEHERLHREALE--RDW-VALTTYQEQAQQ----LLELQRSLD-------------- 1128
            |........|.:.| |:|||  :.| |:|.....|.|.    :.:...|:|
Zfish  1105 KQREGSNPSELQTL-RDALEEAQRWNVSLQARLGQIQNRGGGVGQANDSVDTLSMIGDQTSYMSI 1168

  Fly  1129 -YHQENEKELKQTLVENELATRALKKQLDESTLQASKAVMERTKAYN-----------DKLQLEK 1181
             ..:..|:||....|: :|..:.|:.:...:.||....::|:....|           |.:.|..
Zfish  1169 CVGEGPEEELLHMTVD-QLRLKVLELEAVNAELQKKLVLLEKDTVGNAPIGSHSQKEPDLIDLST 1232

  Fly  1182 RSEELRLQLEALKEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATTCKQAAAAVLGQRV 1246
            .:::.:.|.:...||...||  .||..:..:.|..|.:..|.|..||...   ||.:|      |
Zfish  1233 PTKQPQRQQKPTSEEGASLL--ASNVKERCEDGDRSSKDRVKMNQPSQMQ---KQLSA------V 1286

  Fly  1247 NTSSPDLGIESDAGRISSV-------EVSNAQRAMLKTVE--------MKTEGSASPKAKSEEST 1296
            ..:|...|.||:...:.|:       .||..:..:.|...        :|.|.:...|..:|.|.
Zfish  1287 QPTSKFPGDESEKAELKSLLSDCGAESVSQLREQVAKLRSEASELRGLLKEENATESKESAESSG 1351

  Fly  1297 SPDSKSNVATGAATVHDCAKVDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQIL 1361
            ..||..:       :|...||....|...||:||        :.|.::...:....:.|.|..:.
Zfish  1352 ESDSHGD-------LHHTVKVLRSEARSHRKIIR--------FLKEQLERNSDGVTQLDTKVMVS 1401

  Fly  1362 KTHNV 1366
            ...||
Zfish  1402 MAGNV 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:462333	13/93 (14%)
		Smc	<138..>404	CDD:440809	53/286 (19%)
		SMC_prok_B	498..1200	CDD:274008	186/839 (22%)
		Smc	<929..>1247	CDD:440809	83/375 (22%)
cdk5rap2	XP_009293383.1	SMYLE_N	1..>102	CDD:465822	12/51 (24%)
		SMC_prok_B	<303..1002	CDD:274008	184/848 (22%)
		EnvC	914..>1160	CDD:443969	62/266 (23%)
		COG2433	<1312..>1443	CDD:441980	23/110 (21%)
		SMC_prok_B	<2388..>2652	CDD:274008