DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cnn and cdk5rap2

DIOPT Version :9

Sequence 1:	NP_001246293.1	Gene:	cnn / 36491	FlyBaseID:	FBgn0013765	Length:	1378	Species:	Drosophila melanogaster
Sequence 2:	XP_009293383.1	Gene:	cdk5rap2 / 334460	ZFINID:	ZDB-GENE-030131-6392	Length:	2913	Species:	Danio rerio

Alignment Length:	1565	Identity:	325/1565 - (20%)
Similarity:	580/1565 - (37%)	Gaps:	425/1565 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GTCASSLKEITLIETVTSFLEENGAAEIDRRVLRKLAEALSKSID----------------DTSP 65
            |.|...|:.|...:.....|:|..||::.:  |.|..:.|...|.                |..|
Zfish    52 GKCVFLLERIVQCDVTIGQLQETHAAQLQQ--LEKERDGLKTQITNKYRQHNPTGSKLLKWDVQP 114

  Fly    66 GALQDVTMENSYASFDVPRPPGGGNSPLPSQGRSVREL-------EEQMS-ALR----------- 111
            ||.  :.......|...|:|.....|.:....|..|::       |::.: :||
Zfish   115 GAC--LYTPKQLQSMQCPQPKQSQISDIQETTRRNRKVVSANLGCEKKFAGSLRRCVSLEPLCKV 177

  Fly   112 ------KENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAKIEIATLRKTVDVKMELLKDAAR 170
                  :...|.:|:...:...:|        .|||:..:|...:.::|.:::.::...|::...
Zfish   178 GTDRSHRSKLNSRLKAADVPAPRP--------RSLSRDYLDVVNKKSSLSRSISLQSVALENTDH 234

  Fly   171 AISHHEELQR---KADIDSQAIIDELQEQIHAYQ----MAESGG-------QPVENIAKTRK--- 218
            |:.......|   .|.::..:::.::.:.:...|    :...||       .|:.:.|.|.|
Zfish   235 ALIRQTRPFRGSTPAAVEKTSLVFDILQLLKIVQGVRFVPRCGGSRIPVLKHPLHSHANTHKGGV 299

  Fly   219 --MLRLESEVQRLEEELVNIEARNVAARNELEFMLAERLESLTACEGKIQELAIKNSELVERLEK 281
              ..|:|..::.:|:|. |.:.|.:            :.|.:...:.::..|..|..:|.|.|.|
Zfish   300 SWKSRVERNLREMEDEF-NDDYRPL------------KREIIVDRQNELSRLEQKTRQLTEELNK 351

  Fly   282 ETASAESSNEAIDSLKVELEACRKENQDLVTSIRTLKHDMKRQVRSMKEAANTM--DVQRQSILL 344
            ...:.::..:|:|.::.|.:|...|.|             ||::....|..|::  |...|.:.|
Zfish   352 AKNNGQTLKDALDEMEKEKKALSDELQ-------------KREIELSTEKKNSLKRDKAIQGLTL 403

  Fly   345 LEATIKRKEKSCGSMQKNVLNYEALIAKLNAELETMRQQNVYFRELSENLQQKEVRQLDRGVAIV 409
            .   :|.|||....:..::...:..:||....|...:.|..:..|..::|..::..:|.
Zfish   404 F---LKEKEKEIEDLSGDLEEKDQALAKAREALHKAKLQKYHGAEDQQSLLLEQQAELS------ 459

  Fly   410 QPMRMTADAGRFVWQSGTIVAQEPLPLERQSAAATSNVSVSAVRLSSGPPPDQTYPVNGHDRAKY 474
               |:.|:|     .|..:.||.   |:|...:..|.:|
Zfish   460 ---RLQAEA-----HSSLLEAQR---LQRVLGSRDSELS-------------------------- 487

  Fly   475 GLLQLFAAKLDWISAVPLALGHLALKIILLAMRLHSCLQNVHIPLRANRDLGAQ-------LADK 532
             |||  .|||.                  |...|....|......:...||..|       |||:
Zfish   488 -LLQ--QAKLQ------------------LEQELEQLQQQKKKGDKTINDLQNQLKKLNGTLADR 531

  Fly   533 ICELQEAQEKLKERERIHEQACRTIQKLMQKLSSQEKEIKKLNQENEQSANKENDCAKTVISPSS 597
            ...|.  |::|:::|:|     |..::.||  ::.|:....||.:::|..:..|     ::....
Zfish   532 ENALD--QQRLEQQEQI-----RASEQKMQ--NAMERLTASLNHKDQQLQDYMN-----MVRDLE 582

  Fly   598 SGRSMSDNEASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQ------NLVNKELWEK 656
            ..||..:.:    .|...||.|.       :||.|.|:..:.:|.|.::      :|:...|.||
Zfish   583 KNRSQEEGD----PMLAKLRARL-------KEKEKALEKALDEKFAAVEEKENEIHLLQLSLREK 636

  Fly   657 NREVERLTKLLANQQKTLPQ----ISEESAGEADLQQSF------------TEAEYMRAL-ERNK 704
            .|:||||..||::.::|:..    |.|.   :.:|||..            ||....||| |::.
Zfish   637 ERDVERLNNLLSHNEETINSFDAVIKER---DLELQQLLNSLKNLQRSKDETEENLHRALREKDA 698

  Fly   705 LLQRKVDVLFQRLAD-DQQNSAVIGQ-------------LRLELQQARTEVETADKWRLECVDVC 755
            ::|.....|..:..| ::..:.|:.|             .||::.:|.......|:.||
Zfish   699 IIQHLQQALDNKTKDMEEMANRVLNQSESQGRDLAEQMSQRLKVTEAMLSEAVKDRERL------ 757

  Fly   756 SVLTNR--LEELAGFLNSLLKHKDVLGVLAADRRNAMRKAVDRS---LDLSKSLNMT-------- 807
             |..|:  :|.|...::|    ||.|  |............|||   |||.|.|:.|
Zfish   758 -VTENQTAVENLLATISS----KDQL--LKESMERHTHTLSDRSAEMLDLRKQLSDTQQQLRNAQ 815

  Fly   808 -LNITATSLADQSLAQLCNLSEILYTEGDA---------SHKTFNSHEELHAATSMAPTVENLKA 862
             ||..||......:|:|    ..:.:|.||         ..|..:...|:.:..:..|.|..|:.
Zfish   816 RLNAAATQDGHLEIAEL----RAMLSEKDALINKLLERGQEKDRSILFEMKSGEAPPPQVLELRQ 876

  Fly   863 ENKALKKELEKRRSSEGQRKERRSLPLPSQQFDNQSESEAWSEPDRKVSLARIGLDETSN----- 922
            ..:.|:::||:|.:...:|.....|.:     |..::..|       |.|.|..|.:|..
Zfish   877 TIELLQEKLEEREAELSRRNSEEMLDV-----DAVTKKSA-------VLLKRELLQKTDALNAAL 929

  Fly   923 --------SLAAPEQAISESES--EGRTC---ATRQDRNRNSERIAQLEEQIAQK-DERMLNVQC 973
                    |||..:.::||.|:  ||:|.   :.....|...|.|.:|..:::|: |.|:...:.
Zfish   930 KRENQLKISLAELQSSLSELEARLEGQTANIESLTSTLNTKEEIITELHHRLSQRGDSRVPLTRD 994

  Fly   974 QMVEL-DNRYKQEQLRCLDIT------QQLE-----QLRA----INEALTADLHAIGSHEEERMV 1022
            |..:| ::.|....|...:.|      |||:     .||:    :|.||.|:.|...
Zfish   995 QASQLGESEYSPSSLPQRETTIIGGDRQQLDVASLSDLRSEQAELNRALRAEQHLYS-------- 1051

  Fly  1023 ELQRQLELKNQQIDQLKLAHSTLTADSQITEMELQA---LQQQMQEIEQLHADSVETLQSQLQKL 1084
            :|.|.:: :...:::|           |:.::||.|   |:||::...|::::..:.||:::.:.
Zfish  1052 DLIRAVK-ERDSVERL-----------QVLQLELTAVALLRQQLESGVQMNSELRDQLQTEIHRT 1104

  Fly  1085 KLDAVQQLEEHERLHREALE--RDW-VALTTYQEQAQQ----LLELQRSLD-------------- 1128
            |........|.:.| |:|||  :.| |:|.....|.|.    :.:...|:|
Zfish  1105 KQREGSNPSELQTL-RDALEEAQRWNVSLQARLGQIQNRGGGVGQANDSVDTLSMIGDQTSYMSI 1168

  Fly  1129 -YHQENEKELKQTLVENELATRALKKQLDESTLQASKAVMERTKAYN-----------DKLQLEK 1181
             ..:..|:||....|: :|..:.|:.:...:.||....::|:....|           |.:.|..
Zfish  1169 CVGEGPEEELLHMTVD-QLRLKVLELEAVNAELQKKLVLLEKDTVGNAPIGSHSQKEPDLIDLST 1232

  Fly  1182 RSEELRLQLEALKEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQATTCKQAAAAVLGQRV 1246
            .:::.:.|.:...||...||  .||..:..:.|..|.:..|.|..||...   ||.:|      |
Zfish  1233 PTKQPQRQQKPTSEEGASLL--ASNVKERCEDGDRSSKDRVKMNQPSQMQ---KQLSA------V 1286

  Fly  1247 NTSSPDLGIESDAGRISSV-------EVSNAQRAMLKTVE--------MKTEGSASPKAKSEEST 1296
            ..:|...|.||:...:.|:       .||..:..:.|...        :|.|.:...|..:|.|.
Zfish  1287 QPTSKFPGDESEKAELKSLLSDCGAESVSQLREQVAKLRSEASELRGLLKEENATESKESAESSG 1351

  Fly  1297 SPDSKSNVATGAATVHDCAKVDLENAELRRKLIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQIL 1361
            ..||..:       :|...||....|...||:||        :.|.::...:....:.|.|..:.
Zfish  1352 ESDSHGD-------LHHTVKVLRSEARSHRKIIR--------FLKEQLERNSDGVTQLDTKVMVS 1401

  Fly  1362 KTHNV 1366
            ...||
Zfish  1402 MAGNV 1406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cnn	NP_001246293.1	Cnn_1N	101..170	CDD:285263	13/93 (14%)
		HMMR_N	891..1203	CDD:292527	82/382 (21%)
		FAM76	<1019..1087	CDD:292665	14/70 (20%)
cdk5rap2	XP_009293383.1	zf-AD	5..>63	CDD:285071	4/10 (40%)
		Smc	325..1126	CDD:224117	211/958 (22%)
		FH2	<357..434	CDD:302999	19/92 (21%)
		SMC_prok_B	800..>1613	CDD:274008	146/671 (22%)
		MIT_CorA-like	<874..>969	CDD:294313	23/106 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9874
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4513
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005726
OrthoInspector	1	1.000	-	-		oto39862
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46501
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.150