DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cnn and Cdk5rap2

DIOPT Version :9

Sequence 1:NP_001246293.1 Gene:cnn / 36491 FlyBaseID:FBgn0013765 Length:1378 Species:Drosophila melanogaster
Sequence 2:NP_666102.2 Gene:Cdk5rap2 / 214444 MGIID:2384875 Length:1822 Species:Mus musculus


Alignment Length:1933 Identity:370/1933 - (19%)
Similarity:653/1933 - (33%) Gaps:722/1933 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 SFLEENGAAEIDRRVLRKLAEALS--KSIDDTSPGALQDVTMENSYASFDVPRPPGGGNSPLPS- 95
            |.:||.||          |...||  ..:....|..| ||..:.|          |.||..||| 
Mouse     3 SGMEEEGA----------LPGTLSGCSGLHPVLPSDL-DVISDTS----------GLGNGVLPSM 46

  Fly    96 --------QGRSVRELEEQMSALRKENFNLKLRIYFLEEGQPGARADSSTESLSKQLIDAKIEIA 152
                    :.|::::.|.|::.|:|||||||||||||||......| ..||.:.|..|:.|:|:.
Mouse    47 SEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFA-GPTEHIYKTNIELKVEVE 110

  Fly   153 TLRKTVDVKMELLKDAARAISHHEELQRKADIDSQAIIDELQEQIHAYQMAESGGQPVENIAKTR 217
            :|::.:..|.:||..|::|:   |.|..:...:.|.:.::.::::          |.||::. |:
Mouse   111 SLKRELQEKDQLLVKASKAV---ESLAERGGSEVQRVKEDARKKV----------QQVEDLL-TK 161

  Fly   218 KMLRLESEVQRLEEELVNIEARNVAARNELEFMLAERLESLTACEGKIQE--------------- 267
            ::..||.:|:..:.||     ....|..|.|..|...|||..:...|:||               
Mouse   162 RIHLLEEDVKAAQAEL-----EKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEEKDRL 221

  Fly   268 -----LAIKNSE-LVERLEKETASAESSNEAIDSLKV-------------ELEACRKENQDLVTS 313
                 |::|:.| |::.|::|.:...|.:|.:.|.::             :.|..:||.......
Mouse   222 IEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEEWQKERNHFEER 286

  Fly   314 IRTLKHDMKRQVRSM-KEAANTMDVQRQSILLLEATIKRKEKSCGSMQKNV-------------- 363
            |:.|:.|::.:.|.: .|..|.:. ..::|..|...:|.||:....:...:              
Mouse   287 IQALQEDLREKEREIATEKKNNLK-SYKAIQGLTMALKSKEREVEELDSKIKEVTTDSTKGREDP 350

  Fly   364 ---------------------LNYEALIAKLNAELETMRQQNVYFRELSENLQ---------QKE 398
                                 :..|||:|||::|..|...:|   ..|..|::         :||
Mouse   351 LKTQIPRFQLREGSEDCEAALVEKEALLAKLHSENVTKSTEN---HRLLRNVKKVTQELNDLKKE 412

  Fly   399 VRQLD-----------RGVAIVQPMRMTADAGR-FVWQSGTIVAQ--EPLPLERQSAAATSNVSV 449
            ..:|:           ||...:..:|...:..| .|.:....|.:  :.||.|.::...|....|
Mouse   413 KLRLEQALEEAHQEGNRGARTIHDLRNEVEKLRKEVSEREKAVEKHYKSLPGESKTKFHTQEQVV 477

  Fly   450 SAVRLSSGPPPD---------------QTYPVNGHDRAKYGLLQLFAAKLDWISAVPLALGHLAL 499
            .:: ..||...|               |...:...:..|:|...|...|....|.        ..
Mouse   478 RSL-TGSGSQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGSDGLITEKCSQQSP--------DS 533

  Fly   500 KIILLAMRLHSCLQNVHIPLRANRDLGAQLA-----DKICELQ-EAQEKLKERERIHEQ--ACRT 556
            |:|....:..|..:.:...|:|.:::.|.||     |.:..|| |.:|.|..|:::.:.  |.|.
Mouse   534 KLIFSKEKQQSEYEGLTGDLKAEQNIYAHLAKTQDTDSVSNLQAELKEVLALRKQLEQDVLAYRN 598

  Fly   557 IQKLMQ----KLSSQEKE---------------IKKLNQ------ENEQSANKEND--------- 587
            :||.:|    ::.|:|:|               :::.||      ..|:...|.:|         
Mouse   599 LQKALQEQLSEIRSREEEPFSFYSDQTSYLSICLEEHNQFQLEHFSQEELKKKVSDLIQLVKDLH 663

  Fly   588 -----CAKTVISPSSSGRSMSDN-EASSQEMSTNLRVRYELKINEQEEKIKQLQTEVKKKTANLQ 646
                 ..||:...||.|...||. |.:.||         ||..::::|...:.:.:|:....:.|
Mouse   664 TDNQHLKKTIFDLSSVGFQGSDRLELTKQE---------ELVASKEDEDTLKFEADVETPFQSDQ 719

  Fly   647 NLVNKELWEKNREV--------------------------------------------------- 660
            :|      |::||:                                                   
Mouse   720 HL------EQSREIMEDYAEGGCKSGYGRHMDSNILGHDGAQTPGASEEHTLEDELLGLLATLFS 778

  Fly   661 ERLTKLLANQ-------------------------------QKTLPQIS---------------- 678
            ::.|.||.::                               :|.|.|::                
Mouse   779 KKATPLLESRPDLLKALGALLLERICLAEQGRPGDHLDSKTEKALQQVAVQLRDELGHSFPANSF 843

  Fly   679 ----------------------------------------------------------------- 678
                                                                             
Mouse   844 SKSYNEVKSMWGNWLVKTGDEDTVELKSVSVQTMAIEDTPHGFKPQSKRDAWAEKQEEAIFSTEL 908

  Fly   679 -EESAGEADLQQ----SFTEAEYMRALERNKLLQRKVDVLFQRLAD-DQQNSAVIGQLR---LEL 734
             .|:.||...||    ||..|....|.:...|:|.|...|.:.|.: ......|:.||:   |||
Mouse   909 ESEALGEMPGQQATHLSFPSAINPDAEKTGLLIQLKTPELLENLYNLPASPEVVVAQLQGQVLEL 973

  Fly   735 QQARTEVETADKWRLECVDVCSVLTNRLEELAGFLNSLLKHKDVLGVLAADR--RNAMR------ 791
            |:...|.:|.:|...|.:    :|...:.|.....||.|     :.|.||..  |.|.:      
Mouse   974 QRELKEFKTRNKQLHEKL----ILAEAMMEGLPVPNSAL-----VNVPAAQAVVRTAFQDNPGEQ 1029

  Fly   792 ------KAVDRSLDLSKSLNMTLNITATSLADQSLAQL--C--NLSEILYTEGDASHKTF-NSHE 845
                  ::..|..|:......:..|.:.......||.|  |  ||.::|   |.:|..|: :|..
Mouse  1030 EGPETTQSAGRDKDMDSDQYTSFEIDSEICPPDDLALLPACKENLEDLL---GPSSIATYLDSKS 1091

  Fly   846 ELHAATSMAPT-----------VENLKAENKALKKELEKRR------------------------ 875
            :|....|:..|           .|:||.:...|:.|||..|                        
Mouse  1092 QLSVKVSVNGTDQSENINIPDDTEDLKQKIHDLQTELEGYRNIIVQLLKHSQCSEAIITVLCGTE 1156

  Fly   876 -SSEGQRKERRSL-----------------------PLPSQQFDNQ-----------SESEAWSE 905
             :.:|..|.:..:                       ||..:..|.:           .|.|...|
Mouse  1157 GAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEMIDGKMLESLKQQLVDQEQELQKE 1221

  Fly   906 PDRKVSLARIG-LDETSNSL--AAPEQAISESESEGRTCATRQDRNRNSERIAQLEEQIAQKDER 967
            .|  ::|...| :.:..|..  .:|.:..|..:|:.|..:.::.:.::|..|..:..|......:
Mouse  1222 QD--LNLELFGEIHDLQNKFQDLSPSRYDSLVQSQARELSLQRQQIKDSHGICVIYRQHMSTMIK 1284

  Fly   968 MLNVQCQMVELDN----RYKQEQLRCLDITQQLEQ---------------------LRAI----- 1002
            ......|..::|:    .::::..:|..:.:|||:                     ||.:     
Mouse  1285 AFEELLQASDVDSCVAEGFREQLTQCAGLLEQLERLFLHGKSARVEPHPQNELLKGLRTVEGNLP 1349

  Fly  1003 -------------NEALTAD---------------------------------------LHAIGS 1015
                         :.||:.|                                       :..:..
Mouse  1350 YHHLLPESPEPSASHALSDDEMSEKSFLSRDPKPDSDTEKYPAMASHFPQDLLMEHIQEIRTLRK 1414

  Fly  1016 HEEERM---VELQRQLELKNQQIDQ---------LKLAHSTLTADSQITEMELQALQQQMQ---- 1064
            |.||.:   .:|::|||.:..:.||         |.| ||:||::......:.:||...::    
Mouse  1415 HLEESIKTNEKLRKQLERQGSETDQGSRNVSACGLAL-HSSLTSEIHFLRKQNEALSMMLEKGSK 1478

  Fly  1065 ----EIEQLHADSVETLQSQLQKLKLDAVQQLEEHERLHREALERDWVALTTYQEQAQQLLELQR 1125
                |.|:|. :|:......|::|:|:.....||:|||.|:.:|::    ...||..:::...::
Mouse  1479 DKQKESEKLR-ESLARKAESLEQLQLEYTSVREENERLQRDIIEKE----RHNQELTEEVCSSRQ 1538

  Fly  1126 SLDYHQENEKELKQTLVENELATRALKKQLDESTLQASKAVMERTKAYNDKLQLEKRSEELRLQL 1190
            .|...||..|..:|.|.:.:...::|:.:|               |.|                 
Mouse  1539 ELSRVQEEAKSRQQLLSQKDKLLQSLQMEL---------------KVY----------------- 1571

  Fly  1191 EALKEEHQKLLQKRSNSSDVSQSGYTSEEVAVPMGPPSGQAT-----------TCKQAAAA---- 1240
            |.|.|||.:|.|..|...:.|.:.:...|....|.|.|...|           :|...::|    
Mouse  1572 EKLAEEHPRLQQDGSKCPEASDNSFDLFESTQAMAPKSASETPLLSGTDVDSLSCDSTSSATSPT 1636

  Fly  1241 -----VLGQRVNTSSPD---LGIESDAGRISSVEVSNAQRAMLKTVEMKTEGSASPKAKSEESTS 1297
                 |.|..:..|...   ||:..|...:.. ::|..| .:|..::::|:.:.||   :.....
Mouse  1637 SMPCLVAGHHMWASKSGHHMLGLIEDYDALYK-QISWGQ-TLLAKMDVQTQEALSP---TSHKLG 1696

  Fly  1298 PDSKSNV--------------------------------ATGAATVHDCAKV---DLENAELRRK 1327
            |...|:|                                ..|..::| |.::   ..||.:|.:|
Mouse  1697 PKGSSSVPLSKFLSSMNTAKLVLEKASRLLKLFWRVSVPTNGQCSLH-CEQIGEMKAENTKLHKK 1760

  Fly  1328 LIRTKRAFEDTYEKLRMANKAKAQVEKDIKNQILKTHNVLRNVRSNME 1375
            |...::..::|   .::..::|.| ||.|.:|::.||.|||..|.|:|
Mouse  1761 LFEQEKKLQNT---AKLLQQSKHQ-EKVIFDQLVITHQVLRKARGNLE 1804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cnnNP_001246293.1 Cnn_1N 101..170 CDD:285263 30/68 (44%)
HMMR_N 891..1203 CDD:292527 75/427 (18%)
FAM76 <1019..1087 CDD:292665 21/87 (24%)
Cdk5rap2NP_666102.2 Interaction with NCKAP5L. /evidence=ECO:0000250|UniProtKB:Q96SN8 57..195 48/157 (31%)
Cnn_1N 60..128 CDD:285263 30/68 (44%)
ERM 146..401 CDD:279153 53/274 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1022..1046 2/23 (9%)
Interaction with PCNT and AKAP9. /evidence=ECO:0000269|PubMed:20471352 1201..1822 122/654 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1350..1391 3/40 (8%)
PRK13923 <1438..1560 CDD:276343 32/127 (25%)
Required for centrosomal attachment, Golgi targeting and CALM1 interaction. /evidence=ECO:0000250 1655..1822 35/160 (22%)
Interaction with CDK5R1. /evidence=ECO:0000250 1655..1697 9/46 (20%)
Interaction with PCNT. /evidence=ECO:0000269|PubMed:20471352 1688..1822 28/125 (22%)
Required for centrosomal attachment, Golgi localization and CALM1 interaction. /evidence=ECO:0000250 1790..1799 5/8 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10851
eggNOG 1 0.900 - - E1_2BXW1
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 149 1.000 Inparanoid score I4370
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005726
OrthoInspector 1 1.000 - - oto94588
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4875
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.980

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