Protein Alignment Ser8 and PLAT

DIOPT Version :10

• Sequence 1: NP_610874.1
• Gene: Ser8 / 36489
• FlyBaseID: FBgn0019928
• Length: 260
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 251
• Identity: 79/251 - (31%)
• Similarity: 119/251 - (47%)
• Gaps: 35/251 - (13%)

  Fly    34 RIVGGTASSIEDRPWQVSL----QRS-GSHF-CGGSIISNNIIVTAAHCLDTPTTVSNLRIRAGS 92
            ||.||..:.|...|||.::    :|| |..| |||.:||:..|::||||........:|.:..|
Human   310 RIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILG- 373

  Fly    93 NKRTYGGV------LVEVAAIKAHEAYNSNSKINDIGVVRLKTKLT----FGSTIKAITM--ASA 145
              |||..|      ..||.....|:.::.::..|||.:::||:..:    ..|.::.:.:  |..
Human   374 --RTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADL 436

  Fly   146 TPAHGSAASISGWGKTSTDGP-SSATLLFVDTRIVGRSQCGSSTYGYGSFIKATMICAAATNK-- 207
            .....:...:||:||.....| .|..|.....|:...|:| :|.:.....:...|:||..|..
Human   437 QLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRC-TSQHLLNRTVTDNMLCAGDTRSGG 500

  Fly   208 ------DACQGDSGGPLV--SGGQ--LVGVVSWGRDCAVANYPGVYANIAELRDWV 253
                  ||||||||||||  :.|:  |||::|||..|...:.||||..:....||:
Human   501 PQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWI 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ser8	NP_610874.1	Tryp_SPc	35..253	CDD:238113	77/248 (31%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005
		Tryp_SPc	313..559	CDD:238113	77/248 (31%)