DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ser8 and PRSS36

DIOPT Version :9

Sequence 1:	NP_610874.1	Gene:	Ser8 / 36489	FlyBaseID:	FBgn0019928	Length:	260	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	294	Identity:	89/294 - (30%)
Similarity:	128/294 - (43%)	Gaps:	54/294 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALTNGAVIPIGLEPQTSSLG-----GRIVGGTASSIEDRPWQVSLQRSGSHFCGGSIISNNIIVT 72
            |..:.|:.|...||:....|     .|||||:.:.....||||||...|.|.||||:|:.:.:::
Human    20 AFQDSALSPTQEEPEDLDCGRPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLS 84

  Fly    73 AAHCLDTPTTVSN-------LRIRA------GSNKRTYGGVLVEVAAIKAHEAYNSNSKINDIGV 124
            ||||..|..|:..       |.:.:      |::.|.       ||||.....|:......|:.:
Human    85 AAHCFMTNGTLEPAAEWSVLLGVHSQDGPLDGAHTRA-------VAAIVVPANYSQVELGADLAL 142

  Fly   125 VRLKTKLTFGSTIKAITM--ASATPAHGSAASISGWGKTSTDGPSSA--TLLFVDTRIVGRSQCG 185
            :||.:..:.|..:..:.:  ||....||:|...:|||......|...  .|..|:.|::|.:.|.
Human   143 LRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQ 207

  Fly   186 SSTYGYGSF-----IKATMICAA--ATNKDACQGDSGGPLV--SGGQ--LVGVVSWGRDCAVANY 239
            ......|.|     |...|:||.  ...:|.||||||||||  .||:  ..|:.|:|..|...|.
Human   208 CLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNR 272

  Fly   240 PGVYANIAELRDWV--------------LQAQKT 259
            |||:..:|....|:              .|.|||
Human   273 PGVFTAVATYEAWIREQVMGSEPGPAFPTQPQKT 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ser8	NP_610874.1	Tryp_SPc	34..253	CDD:214473	78/246 (32%)
Ser8	NP_610874.1	Tryp_SPc	35..253	CDD:238113	77/245 (31%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	78/246 (32%)
		Tryp_SPc	47..289	CDD:238113	78/248 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316		4/15 (27%)
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940