DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A and DNF1

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_011093.3 Gene:DNF1 / 856913 SGDID:S000000968 Length:1571 Species:Saccharomyces cerevisiae


Alignment Length:1500 Identity:463/1500 - (30%)
Similarity:713/1500 - (47%) Gaps:312/1500 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 LNSANSNLGFIDSDTPN-TPVTPVSGLQPPASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKS 173
            ||:.:.....::.|..: .|.|...|::               |.|...:::.||:.:   .|:|
Yeast    88 LNNGSGTFDDVELDNDSGEPHTNYDGMK---------------RFRMGTKRNKKGNPI---MGRS 134

  Fly   174 RVSLLAQRGLRMTASFLRRKRTEYEDDEDFTSSAGYDADDG------ERRIINLNGPQP------ 226
            :....|::.:.             ...||||..   |.|.|      |.|.:..|.|.|      
Yeast   135 KTLKWARKNIP-------------NPFEDFTKD---DIDPGAINRAQELRTVYYNMPLPKDMIDE 183

  Fly   227 -----TKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLM 286
                 .:|..|:|.|.||:.::|||..:..||..::|.:||::.||........|....:.|||:
Yeast   184 EGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLV 248

  Fly   287 FILSVSAIKEIIEDIKRHRADNEINH--------------------------------------- 312
            .|:.::|||:.|||.:|...|.|:|:                                       
Yeast   249 VIVIITAIKDAIEDSRRTVLDLEVNNTKTHILEGVENENVSTDNISLWRRFKKANSRLLFKFIQY 313

  Fly   313 ---------------------------------RSIERLDS-------------------GS--- 322
                                             .|::.:||                   |:   
Yeast   314 CKEHLTEEGKKKRMQRKRHELRVQKTVGTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEA 378

  Fly   323 --------------WCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETN 373
                          :....|..:.||||:::..|...|||:||||:|:....|::||.|||||||
Yeast   379 NIVDRSLPPRTDCKFAKNYWKGVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETN 443

  Fly   374 LKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLR-------ETGKPPAALGNDQVL 431
            ||:||:|..|..:..:||:.|.:..||.|.|:.:||.:.|.::       |....|..:.|  ||
Yeast   444 LKVRQSLKCTNTIRTSKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINN--VL 506

  Fly   432 QRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCN 496
            .||..||||.|..|:|:::|.:||:|.||...|.|:|.:.:..|..:::.|::|..||.:||:.|
Yeast   507 LRGCTLRNTKWAMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIAN 571

  Fly   497 -LFWTRE-HSETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELVRFLQAIFINY 556
             :::.:: .|...:..|.......:.|:  ::|:   |||.:|:||||.:::|:::..||.||..
Yeast   572 GVYYDKKGRSRFSYEFGTIAGSAATNGF--VSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYG 634

  Fly   557 DIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERT----- 616
            |:.:|:.:.:.|...::.|::::||.|:||||||||||||||||||||:|.|..|....|     
Yeast   635 DVLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYTEALAG 699

  Fly   617 -----------------------------------------PEE-----SQLVQNILGR--HETS 633
                                                     |||     .:.|:::.|.  ....
Yeast   700 LRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVRDLKGASGEVQQ 764

  Fly   634 AVIEEFLELLSVCHTVIPERKENG--NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALG 696
            ...|.|:..|::||:|:.|...:.  .:...|.||||.|||..|:..|:.|..:|.|.:.|...|
Yeast   765 RCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQG 829

  Fly   697 VRKRYEVLNVLEFTSSRKRMSLIVRTP------ENKIKLFCKGADTVIYERLAPQ----GQAFRE 751
            ::|.:|:||:|||.|||||||.||:.|      |.:..|.|||||::||.||:.|    .:|..|
Yeast   830 IQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICKGADSIIYSRLSRQSGSNSEAILE 894

  Fly   752 QTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLG 816
            :|..|||::|::||||||:|..::....|::|::.:|.|:.:|.|||.:||..|:.||..|.|||
Yeast   895 KTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLG 959

  Fly   817 ATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILN-------- 873
            .||||||||||||:.|..|.:|||.:|||||||.|||||||:||.|:::.|:::::.        
Yeast   960 GTAIEDRLQDGVPDCIELLAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKE 1024

  Fly   874 -----EESLDATREVIHRHYGEFKSS------SAKD-----ANVALVIDGTTLKYAL-SCDLRND 921
                 .|.:||......:.|.....|      :.||     .|.|:||||..||.|| ..|:|..
Yeast  1025 FGSEPSEIVDALLSKYLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRK 1089

  Fly   922 FQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQ 986
            |..||..||.|:||||||.|||.||::|..|.:.:|||||||:|||||||.|:|||||:|.||.|
Yeast  1090 FLLLCKNCRAVLCCRVSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQ 1154

  Fly   987 AACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFER 1051
            |...|||:|.|||||.||:||||.|:|.|::::|...||||:...:...|:.:|:.:.|..|:|.
Yeast  1155 AVMCSDYAIGQFRYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEY 1219

  Fly  1052 WTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFL 1116
            ..:..||:.||::|...:|:.::.......:..|.||:.....|.:|.:.|..::.:.|..|:..
Yeast  1220 TYMMFYNLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIIC 1284

  Fly  1117 FWLPLAAYTKE-VIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITN-SWTWLTHLAIWGSIVLW 1179
            |:.|...|.|. ::.|:|...|:.....:..|.:.|..|....|:.. .|.|.:.|.|..|.::.
Yeast  1285 FFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIALSCLVV 1349

  Fly  1180 FGFLLIYSHV---WPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTL 1241
            |.:..|:|..   ...||.|:...|       .|.|:....:..:..||............:.|.
Yeast  1350 FAWTGIWSSAIASREFFKAAARIYG-------APSFWAVFFVAVLFCLLPRFTYDSFQKFFYPTD 1407

  Fly  1242 TEAVRE----------------TEIRRSDIS-------EVMNEPRSSDS--GFGYALGKLIRSSH 1281
            .|.|||                |:..|..::       :::.....||:  |..|:...:: :..
Yeast  1408 VEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSNYSRDSVV-TEE 1471

  Fly  1282 ILISHDHHPVSESSRTSNLRVENLEMEADTEQQQ--QSRQRQKWR--GGQVATGVARSARNSTTS 1342
            |.::..|   .|....|..:.:...|.:..|.|.  ||.|.|:.:  |...:|.| ||:.:.|..
Yeast  1472 IPMTFMH---GEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPSTNV-RSSLDRTRE 1532

  Fly  1343 PITAT 1347
            .:.||
Yeast  1533 QMIAT 1537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 20/72 (28%)
ATPase-Plipid 229..1247 CDD:273734 411/1232 (33%)
E1-E2_ATPase 286..>371 CDD:278548 35/192 (18%)
Cation_ATPase 645..741 CDD:289987 45/103 (44%)
HAD_like <942..1001 CDD:304363 38/58 (66%)
PhoLip_ATPase_C 988..1240 CDD:292829 69/256 (27%)
DNF1NP_011093.3 ATPase-Plipid 191..1413 CDD:273734 411/1232 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S688
OMA 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.660

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