Protein Alignment ATP8A and NEO1

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_012216.1
• Gene: NEO1 / 854763
• SGDID: S000001310
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 1228
• Identity: 357/1228 - (29%)
• Similarity: 575/1228 - (46%)
• Gaps: 201/1228 - (16%)

  Fly    64 DFESLEHLTPRASDGLDEQLAASVSHSVHSGGSVTLCGPPDHSSIHLNSANSNLGFIDSDT---- 124
            |.||.|   .|..|.||       :.|.||..|            |..|:|::...:..|.
Yeast    61 DRESFE---MRTVDDLD-------NFSNHSSDS------------HRKSSNTDTHPLMYDNRLSQ 103

  Fly   125 -PNTPVTPVSGLQPPASVSTSVGGTLSSRRRSSNRKDSK-GSILSRQSGKSRVSLLAQRGLRMTA 187
             .|...|.::. .||:|.:......||..:.|:.:..|| ||.:.
Yeast   104 DDNFKFTNIAS-SPPSSSNNIFSKALSYLKVSNTKNWSKFGSPIE-------------------- 147

  Fly   188 SFLRRKRTEYEDDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQ 252
              |..:..|.|...|.|..  ||.:               :|.:|.::.|||:.::|:|..|:||
Yeast   148 --LSDQHIEREIHPDTTPV--YDRN---------------RYVSNELSNAKYNAVTFVPTLLYEQ 193

  Fly   253 FRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEIN------ 311
            |:.:.|.:||::|:.|.:|.:......:.:|||.|:|:|:..||.|:||:|.|.|.|.|
Yeast   194 FKFFYNLYFLVVALSQAVPALRIGYLSSYIVPLAFVLTVTMAKEAIDDIQRRRRDRESNNELYHV 258

  Fly   312 ---HRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETN 373
               :|||...|           |.|||:|||......||||:||.||||....||:|..|||||:
Yeast   259 ITRNRSIPSKD-----------LKVGDLIKVHKGDRIPADLVLLQSSEPSGESFIKTDQLDGETD 312

  Fly   374 LKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILR 438
            .|:|.|.|.|..|.|...:.|:.  |....|.:.:::|.|.:.........|..|..|....:|.
Yeast   313 WKLRVACPLTQNLSENDLINRIS--ITASAPEKSIHKFLGKVTYKDSTSNPLSVDNTLWANTVLA 375

  Fly   439 NTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTN--TQIL--MLFMILISLCIISGLCNLFW 499
            ::.:....|||:|::|:...|:|:|.:|...::...|  ::||  .:|.:.|.|...:|..|
Yeast   376 SSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLELEINSISKILCACVFALSILLVAFAGFHN--- 437

  Fly   500 TREHSETDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEE 564
                  .|||:            ::|.:.||::.:||:||:|.|:|.:.:.|    :.||  |::
Yeast   438 ------DDWYI------------DILRYLILFSTIIPVSLRVNLDLAKSVYA----HQIE--HDK 478

  Fly   565 SNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILG- 628
            :....:.|||.:.|:||.::|:.||||||||||.|:.||..:....||:|.....|..||:::.
Yeast   479 TIPETIVRTSTIPEDLGRIEYLLSDKTGTLTQNDMQLKKIHLGTVSYTSETLDIVSDYVQSLVSS 543

  Fly   629 ---------------RHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKF 678
                           |.:.|..:.:.:..|::||.|.| ..|:..:.|.||||||.|:|:..:..
Yeast   544 KNDSLNNSKVALSTTRKDMSFRVRDMILTLAICHNVTP-TFEDDELTYQAASPDEIAIVKFTESV 607

  Fly   679 GYIFDTRTPKYVEI--NALGVRKRYEVLNVLEFTSSRKRMSLIVRTPE-NKIKLFCKGADTVIYE 740
            |.....|....:.:  ...|....||:|.|..|.|..|||.:|||..: ::.....||||||: .
Yeast   608 GLSLFKRDRHSISLLHEHSGKTLNYEILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVM-S 671

  Fly   741 RLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDA- 804
            ::........|:|    ...|.:|||||.:....:...:|:::.:.::.||:::.||:.::...
Yeast   672 KIVESNDWLEEET----GNMAREGLRTLVIGRKKLNKKIYEQFQKEYNDASLSMLNRDQQMSQVI 732

  Fly   805 ANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDI 869
            ...:|::|.|||.|.:||:||..|..:|..|.:|||.||:|||||.|||..:..|.:|||....:
Yeast   733 TKYLEHDLELLGLTGVEDKLQKDVKSSIELLRNAGIKIWMLTGDKVETARCVSISAKLISRGQYV 797

  Fly   870 IILNEESLDATREVIHRHYGEFKSSS--AKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVV 932
            ..:.:         :.|..|.|....  ..:.|..|:|||.:|...|. ....:|.|:.:....|
Yeast   798 HTITK---------VTRPEGAFNQLEYLKINRNACLLIDGESLGMFLK-HYEQEFFDVVVHLPTV 852

  Fly   933 ICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQ 997
            |.||.:|.|||:|..::.:.|......||||.|||:|||.|:||:||.|.||.||:.|:|:||.|
Yeast   853 IACRCTPQQKADVALVIRKMTGKRVCCIGDGGNDVSMIQCADVGVGIVGKEGKQASLAADFSITQ 917

  Fly   998 FRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFT 1062
            |.:|..|||.||..:|.|.:||..:..::.:.:.:.:..:::.|.:....|::.|.:..|...:|
Yeast   918 FCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYSICSLFEPIALYQGWLMVGYATCYT 982

  Fly  1063 AMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKE 1127
            ..|.|::.|......:.|.| ||.|||.....|..:.|.|::|:..:|.....:
Yeast   983 MAPVFSLTLDHDIEESLTKI-YPELYKELTEGKSLSYKTFFVWVLLSLFQGSVI----------- 1035

  Fly  1128 VIWSDGKTS----DYLLMGNLVYTYVIVTVCLKAGLITNSWTW-----LTHLAIWGSIVLWFGFL 1183
            .::|...||    |:..|..:.:|.::|...:...|  ..:||     :|.:|.          |
Yeast  1036 QLFSQAFTSLLDTDFTRMVAISFTALVVNELIMVAL--EIYTWNKTMLVTEIAT----------L 1088

  Fly  1184 LIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTL 1241
            |.|....|   |..::  .|:..::|..:|..|:::    |||.:........:::.|
Yeast  1089 LFYIVSVP---FLGDY--FDLGYMTTVNYYAGLLVI----LLISIFPVWTAKAIYRRL 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	296/923 (32%)
NEO1	NP_012216.1	P-type_ATPase_APLT_Neo1-like	172..1067	CDD:319841	303/962 (31%)
		Cation_ATPase	574..670	CDD:463817	34/96 (35%)