DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8A and DRS2

DIOPT Version :9

Sequence 1:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster
Sequence 2:NP_009376.2 Gene:DRS2 / 851207 SGDID:S000000024 Length:1355 Species:Saccharomyces cerevisiae


Alignment Length:1283 Identity:534/1283 - (41%)
Similarity:774/1283 - (60%) Gaps:121/1283 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 INRDFESLEHLTPRASDGLDEQ------LAASVSHSVHSGGSVTLCGPPDHSSIHLNSANSNLGF 119
            :|.|.|:    .|:...|.|:.      |..:.|||    ||        .|.:..:.||:|.  
Yeast     1 MNDDRET----PPKRKPGEDDTLFDIDFLDDTTSHS----GS--------RSKVTNSHANANY-- 47

  Fly   120 IDSDTPNTPVTPVSGLQPPA---SVSTSVGGTLSSRRR-------SSNRKDSKGSILSRQSGKSR 174
                .|.:.|.|...:...|   ::...|...|.....       ::||.||.............
Yeast    48 ----IPPSHVLPEETIDLDADDDNIENDVHENLFMSNNHDDQTSWNANRFDSDAYQPQSLRAVKP 108

  Fly   175 VSLLAQ--RGLRMTASFLRRKR------------TEYEDDEDFTSSAGY---------------- 209
            ..|.|:  .||:...:|.|:|.            |..|.|:::..|...                
Yeast   109 PGLFARFGNGLKNAFTFKRKKGPESFEMNHYNAVTNNELDDNYLDSRNKFNIKILFNRYILRKNV 173

  Fly   210 -DAD-DGERRIINLNGPQPTK---YGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQ 269
             ||: :||.|:|::|......   |.:|.|:|.||:|.:|||.|||::|.:|:|.|||..:.:||
Yeast   174 GDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFLCTSAIQQ 238

  Fly   270 IPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSG--SWCTVRWSELT 332
            :|.||||.||||:..|:.:|.|||:||.||||||..:|.|:|:.:.|.....  .:...||.::.
Yeast   239 VPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRWIDIR 303

  Fly   333 VGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEG 397
            |||||:|......|||.|:||||||:.:|:||||||||||||||:|:...||:.::.|.|:.:.|
Yeast   304 VGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKIKQSRVETAKFIDVKTLKNMNG 368

  Fly   398 RIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTS 462
            ::..|.||..||.:.|.:....: ...|..||::.|||.||||||:||:|:::|.||||::|:|:
Yeast   369 KVVSEQPNSSLYTYEGTMTLNDR-QIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLRNATA 432

  Fly   463 APLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGY-NLLT 526
            .|:||:.|:|:.|.||:.||.:||.|.:||.:.|:..:...::...||.|.......|.: :.||
Yeast   433 TPIKRTAVEKIINRQIIALFTVLIVLILISSIGNVIMSTADAKHLSYLYLEGTNKAGLFFKDFLT 497

  Fly   527 FFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKT 591
            |:||::||:||||.||:||:::.||..|..|:::|:|:::||.:.|||:|.||||.::|||||||
Yeast   498 FWILFSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTVVRTSSLVEELGQIEYIFSDKT 562

  Fly   592 GTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNIL----------------GRHETSAVIEEFL 640
            ||||:|:||||.|||||:.|..:...:::..|::.:                ...|.|.:|.:||
Yeast   563 GTLTRNIMEFKSCSIAGHCYIDKIPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDFL 627

  Fly   641 ELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI--NALGVRKRYEV 703
            .||:.|||||||.:.:|::.|.||||||.|||:|....||.|..|.|..|.:  ...|..|.|::
Yeast   628 TLLATCHTVIPEFQSDGSIKYQAASPDEGALVQGGADLGYKFIIRKPNSVTVLLEETGEEKEYQL 692

  Fly   704 LNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTL 768
            ||:.||.|:|||||.|.|.|:..||||||||||||.|||..:...:.|.|:||||::||:|||||
Yeast   693 LNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERLDDEANQYVEATMRHLEDYASEGLRTL 757

  Fly   769 CLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIA 833
            |||:.||....|:||:..:::|:..|.||..||::||||||.||.|:|||||||:|||||||||.
Yeast   758 CLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKNLILIGATAIEDKLQDGVPETIH 822

  Fly   834 SLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATR-------EVIHRHYGEF 891
            :|.:|||.|||||||:||||||||.||||:|..|:::|:|||:.|.|.       ..::.|    
Yeast   823 TLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLIINEETRDDTERNLLEKINALNEH---- 883

  Fly   892 KSSSAKDAN-VALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNA 955
             ..|..|.| :||||||.:|.:||..:|.:....:..||:.||||||||:|||.||:||.:.:::
Yeast   884 -QLSTHDMNTLALVIDGKSLGFALEPELEDYLLTVAKLCKAVICCRVSPLQKALVVKMVKRKSSS 947

  Fly   956 VTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLI 1020
            :.||||||||||:|||.|:||:||||:||:|||.::|.::.||::|::||||||:|:|.|||..|
Yeast   948 LLLAIGDGANDVSMIQAAHVGVGISGMEGMQAARSADIAVGQFKFLKKLLLVHGSWSYQRISVAI 1012

  Fly  1021 LYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYP 1085
            |||||||..||:.:.|:...:.:|||.:.|.||:..||:.||..|||.:|:|::|.::..:.|||
Yeast  1013 LYSFYKNTALYMTQFWYVFANAFSGQSIMESWTMSFYNLFFTVWPPFVIGVFDQFVSSRLLERYP 1077

  Fly  1086 MLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKE-VIWSDGKTSDYLLMGNLVYTYV 1149
            .|||..|..:.|:|.:||.||.|...||..:|...:..|... .:...|:.:|:...|..|||..
Yeast  1078 QLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIYRYGFALNMHGELADHWSWGVTVYTTS 1142

  Fly  1150 IVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYF 1214
            ::.|..||.|:||.||..|.:||.||::.|..|..||:.::|....:..:.|:......:.||:.
Yeast  1143 VIIVLGKAALVTNQWTKFTLIAIPGSLLFWLIFFPIYASIFPHANISREYYGVVKHTYGSGVFWL 1207

  Fly  1215 CLMLVPITTLLIDVICKLVHNTVFKTLTEAVRET-----EIRRSDISE 1257
            .|:::||..|:.|.:.|     .:|.:.|.  ||     |:::.:||:
Yeast  1208 TLIVLPIFALVRDFLWK-----YYKRMYEP--ETYHVIQEMQKYNISD 1248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 29/64 (45%)
ATPase-Plipid 229..1247 CDD:273734 485/1047 (46%)
E1-E2_ATPase 286..>371 CDD:278548 42/86 (49%)
Cation_ATPase 645..741 CDD:289987 53/97 (55%)
HAD_like <942..1001 CDD:304363 34/58 (59%)
PhoLip_ATPase_C 988..1240 CDD:292829 94/252 (37%)
DRS2NP_009376.2 ATPase-Plipid 198..1240 CDD:273734 487/1054 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157346817
Domainoid 1 1.000 313 1.000 Domainoid score I201
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 936 1.000 Inparanoid score I37
Isobase 1 0.950 - 0 Normalized mean entropy S688
OMA 1 1.010 - - QHG53737
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 1 1.000 - - oto99182
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - LDO PTHR24092
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1985
SonicParanoid 1 1.000 - - X168
TreeFam 1 0.960 - -
1514.740

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