DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and AT1G68710

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001320718.1	Gene:	AT1G68710 / 843201	AraportID:	AT1G68710	Length:	1226	Species:	Arabidopsis thaliana

Alignment Length:	1170	Identity:	449/1170 - (38%)
Similarity:	663/1170 - (56%)	Gaps:	155/1170 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RRKRTE-------------YEDDEDFTSSAGYDADDGERRIINLNGPQPTK-----YGNNRITTA 237
            ||:|.:             ::.|.......|:.      |::..|.|...:     |.:|.:.|.
plant     9 RRRRLQLSKLYTLTCAQACFKQDHSQIGGPGFS------RVVYCNEPDSPEADSRNYSDNYVRTT 67

  Fly   238 KYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIK 302
            ||:..:|||..|||||||.:|.:||:..:|...| ::|....:.:|||:|::..:.:||.:||.:
plant    68 KYTLATFLPKSLFEQFRRVANFYFLVTGVLAFTP-LAPYTASSAIVPLLFVIGATMVKEGVEDWR 131

  Fly   303 RHRADNEINHRSIE-RLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETA 366
            |.:.|||:|:|.:: ....||:....|..|::|||:||..|.||||||:|||||...|:|::||.
plant   132 RQKQDNEVNNRKVKVHRGDGSFDAKEWKTLSIGDIVKVEKNEFFPADLVLLSSSYEDAICYVETM 196

  Fly   367 NLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNGVLRETG-KPPAALGNDQV 430
            |||||||||::|.|..|:.|.:..:.:..|..::||.||.:||.|.|.:...| |.|  |...|:
plant   197 NLDGETNLKVKQGLEVTSSLRDEFNFKGFEAFVKCEDPNANLYSFVGTMELKGAKYP--LSPQQL 259

  Fly   431 LQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLC 495
            |.|.:.||||.::||.|:::|.:||:::|||..|.|||.::|..:..|.::|.::|::..|..:.
plant   260 LLRDSKLRNTDFIFGAVIFTGHDTKVIQNSTDPPSKRSMIEKKMDKIIYLMFFMVITMAFIGSVI 324

  Fly   496 NLFWTREHSETD----WYLG------LTDFKTKSLG--YNLLTFFILYNNLIPISLQVTLELVRF 548
            ....||:..:..    |||.      ..|.|...:.  |:.||..:||:..|||||.|::|:|:.
plant   325 FGVTTRDDLKDGVMKRWYLRPDSSSIFFDPKRAPVAAIYHFLTAVMLYSYFIPISLYVSIEIVKV 389

  Fly   549 LQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYV--- 610
            ||:||||.||.||:||::.||.|||||||||||.|..|.||||||||.|.|||.|||:||..
plant   390 LQSIFINQDIHMYYEEADKPARARTSNLNEELGQVDTILSDKTGTLTCNSMEFIKCSVAGTAYGR 454

  Fly   611 -----------------------------YTAERTPEESQLV------QNILGRH---ETSA-VI 636
                                         |:.|...|||.:.      :.|:..:   ||.| ||
plant   455 GVTEVEMAMGRRKGGPLVFQSDENDIDMEYSKEAITEESTVKGFNFRDERIMNGNWVTETHADVI 519

  Fly   637 EEFLELLSVCHTVIPERKENGNMI-YHAASPDERALVEGAQKFGYIFDTRTPKYVEINALG---- 696
            ::|..||:||||||||..|:...| |.|.||||.|.|..|::.|:.|..||...:.:..|.
plant   520 QKFFRLLAVCHTVIPEVDEDTEKISYEAESPDEAAFVIAARELGFEFFNRTQTTISVRELDLVSG 584

  Fly   697 --VRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEE 759
              |.:.|:|||||||.|:|||||:||:..:.|:.|.|||||.|::|||:..|:.|.|:|..|:.|
plant   585 KRVERLYKVLNVLEFNSTRKRMSVIVQEEDGKLLLLCKGADNVMFERLSKNGREFEEETRDHVNE 649

  Fly   760 FASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQ-NRESKLEDAANLIENNLRLLGATAIEDR 823
            :|..|||||.||..::....|:.:::...:|..::. :|||.:|:....||.:|.||||||:||:
plant   650 YADAGLRTLILAYRELDEKEYKVFNERISEAKSSVSADRESLIEEVTEKIEKDLILLGATAVEDK 714

  Fly   824 LQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEE-----SLDAT--R 881
            ||:|||:.|..|..|||.||||||||.|||||||::|.|:...|..||:|.|     ||:.|  :
plant   715 LQNGVPDCIDKLAQAGIKIWVLTGDKMETAINIGFACSLLRQDMKQIIINLETPEIQSLEKTGEK 779

  Fly   882 EVIHRHYGEFKSSSAKDANV-------------------ALVIDGTTLKYALSCDLRNDFQDLCI 927
            :||         :.|...||                   ||:|||.:|.|||..|:::.|.:|.:
plant   780 DVI---------AKASKENVLSQIINGKTQLKYSGGNAFALIIDGKSLAYALDDDIKHIFLELAV 835

  Fly   928 LCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASD 992
            .|..|||||.||.|||.|..:|.......|||||||||||.|:|:|::|:|||||||:||..:||
plant   836 SCASVICCRSSPKQKALVTRLVKSGNGKTTLAIGDGANDVGMLQEADIGVGISGVEGMQAVMSSD 900

  Fly   993 YSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLY 1057
            .:|||||||:|||||||.|.|.|||.:|.|.||||:........:..|:.:|....:..|.:.||
plant   901 IAIAQFRYLERLLLVHGHWCYRRISTMICYFFYKNITFGFTLFLYETYTTFSSTPAYNDWFLSLY 965

  Fly  1058 NVLFTAMPPFAMGLFE-----KFC------TAET---------------MIRYPMLYKTSQNAKL 1096
            ||.|:::|..|:|:|:     ::|      ||.:               ::::|:||:......|
plant   966 NVFFSSLPVIALGVFDQDVSARYCLKVNITTALSSHQSKNLCQLLPFFLVLQFPLLYQEGVQNVL 1030

  Fly  1097 FNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLIT 1161
            |:.:....|:||....:|.:|:|..::...:....||||....::|..:||.::..|.|:..|..
plant  1031 FSWRRILGWMFNGFYSAVIIFFLCKSSLQSQAFNHDGKTPGREILGGTMYTCIVWVVNLQMALAI 1095

  Fly  1162 NSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVFYFCLML-VPITTLL 1225
            :.:|.:.|:.||.|||:|:.|:.:|..: |. :.::....:.::.|:..:.|:.:.| |.:.||:
plant  1096 SYFTLIQHIVIWSSIVVWYFFITVYGEL-PS-RISTGAYKVFVEALAPSLSYWLITLFVVVATLM 1158

Fly 1226 1225
plant 1159 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	23/66 (35%)
		ATPase-Plipid	229..1247	CDD:273734	441/1114 (40%)
		E1-E2_ATPase	286..>371	CDD:278548	39/85 (46%)
		Cation_ATPase	645..741	CDD:289987	49/102 (48%)
		HAD_like	<942..1001	CDD:304363	35/58 (60%)
		PhoLip_ATPase_C	988..1240	CDD:292829	80/265 (30%)
AT1G68710	NP_001320718.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	281	1.000	Domainoid score	I393
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	827	1.000	Inparanoid score	I77
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm2889
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840