DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and AT1G17500

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	NP_001319028.1	Gene:	AT1G17500 / 838324	AraportID:	AT1G17500	Length:	1216	Species:	Arabidopsis thaliana

Alignment Length:	1121	Identity:	443/1121 - (39%)
Similarity:	648/1121 - (57%)	Gaps:	122/1121 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 ADDGE----------RRIINLNGP-----QPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCF 260
            ||:|:          .|.:..|.|     :|.||.:|.::|.:|:.|:|.|..|:|||.|.:|.:
plant    25 ADEGQDPHPIQGPGFSRTVYCNQPHMHKKKPLKYRSNYVSTTRYNLITFFPKCLYEQFHRAANFY 89

  Fly   261 FLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEIN------HRSIERLD 319
            ||:.|||...| :||..:::.:.||:|::.:|.:||.:||..|...|.:||      |:|
plant    90 FLVAAILSVFP-LSPFNKWSMIAPLVFVVGLSMLKEALEDWSRFMQDVKINASKVYVHKS----- 148

  Fly   320 SGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATA 384
            .|.:...:|.:::||||:||..:.||||||:|||||....:|::||.|||||||||::::|..|.
plant   149 DGEFRRRKWKKISVGDIVKVEKDGFFPADLLLLSSSYEDGICYVETMNLDGETNLKVKRSLEVTL 213

  Fly   385 ELLETKDLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVY 449
            .|.:....:...|.|.||.||..||.|.|.| |..:....|...|:|.|.:.||||.:|:|:||:
plant   214 SLDDYDSFKDFTGIIRCEDPNPSLYTFVGNL-EYERQIFPLDPSQILLRDSKLRNTPYVYGVVVF 277

  Fly   450 SGQETKLMKNSTSAPLKRSTVDKLTNTQI--LMLFMILISLCIISGLCNLFW-TREHSETDWYL- 510
            :|.:||:|:|||.:|.|||.::|..:..|  |::.:||||....||..   | |:.|....|||
plant   278 TGHDTKVMQNSTKSPSKRSRIEKTMDYIIYTLLVLLILISCISSSGFA---WETKFHMPKWWYLR 339

  Fly   511 -----GLTD-FKTKSLGY-NLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP 568
                 .||: ......|: :|:|..:||..||||||.|::|:|:.|||.|||.|:.||..||..|
plant   340 PEEPENLTNPSNPVYAGFVHLITALLLYGYLIPISLYVSIEVVKVLQASFINKDLHMYDSESGVP 404

  Fly   569 AMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNI---LGRH 630
            |.|||||||||||.|..|.||||||||.|.|:|.||||||..|....:..|....|.:   |..|
plant   405 AHARTSNLNEELGQVDTILSDKTGTLTCNQMDFLKCSIAGTSYGVRSSEVEVAAAQQMAVDLDEH 469

  Fly   631 -------------------ETSAV----------------------------IEEFLELLSVCHT 648
                               |:|..                            |..|..:|::|||
plant   470 GEVSSRTSTPRAQARDIEVESSITPRIPIKGFGFEDIRLMDGNWLREPHTDDILLFFRILAICHT 534

  Fly   649 VIPE-RKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI------NALGVRKRYEVLNV 706
            .||| .:|.|...|.|.||||.:.:..|.:||::|..||...|.:      :...:.:.|:|||:
plant   535 AIPELNEETGKYTYEAESPDEASFLTAASEFGFVFFKRTQSSVYVHERLSHSGQTIEREYKVLNL 599

  Fly   707 LEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLA 771
            |:|||.|||||::||..|.:|.|.|||||::|:||||..|:.:...|.:||.|:...|||||.|:
plant   600 LDFTSKRKRMSVVVRDEEGQILLLCKGADSIIFERLAKNGKVYLGPTTKHLNEYGEAGLRTLALS 664

  Fly   772 VADIRPDVYQEWSQTFDKASVAL-QNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASL 835
            ...:..:.|..|:..|.||..:: .:|:..||..:::||.:|.|:||||:||:||.|||:.|..|
plant   665 YRKLDEEEYSAWNAEFHKAKTSIGSDRDELLERISDMIEKDLILVGATAVEDKLQKGVPQCIDKL 729

  Fly   836 LDAGIYIWVLTGDKQETAINIGYSCRLISHSMD---IIILNEE--SLDATR------EVIHRHYG 889
            ..||:.:|||||||.||||||||||.|:...|.   |.::|.|  |.||..      ..|.:...
plant   730 AQAGLKLWVLTGDKMETAINIGYSCSLLRQGMKQICITVVNSEGASQDAKAVKDNILNQITKAVQ 794

  Fly   890 EFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTN 954
            ..|......|..||:|||.||.|||..:::..|..|.:.|..||||||||.|||.|..:|.:.|.
plant   795 MVKLEKDPHAAFALIIDGKTLTYALEDEMKYQFLALAVDCASVICCRVSPKQKALVTRLVKEGTG 859

  Fly   955 AVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKL 1019
            .:|||||||||||.|||:|::|:|||||||:||..|||:||||||:|:|||:|||.|.|.||:::
plant   860 KITLAIGDGANDVGMIQEADIGVGISGVEGMQAVMASDFSIAQFRFLERLLVVHGHWCYKRIAQM 924

  Fly  1020 ILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRY 1084
            |.|.||||:...:...:|..::|:|||.::..:.:.|:||:.|::|..|:|:||:..::|..:::
plant   925 ICYFFYKNIAFGLTLFYFEAFTGFSGQSVYNDYYLLLFNVVLTSLPVIALGVFEQDVSSEICLQF 989

  Fly  1085 PMLYKTSQNAKLFNVKVFWI----WIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLV 1145
            |.||:..:....|:    |.    |:.|.:..|:.:|:|.:....::.....|:|:|...:|..:
plant   990 PALYQQGKKNLFFD----WYRILGWMGNGVYSSLVIFFLNIGIIYEQAFRVSGQTADMDAVGTTM 1050

  Fly  1146 YTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLS-T 1209
            :|.:|..|.::..|..:.:||:.|:.|||||.||:.|:.:|..:.|  ..:.|...:.:::|: .
plant  1051 FTCIIWAVNVQIALTVSHFTWIQHVLIWGSIGLWYLFVALYGMMPP--SLSGNIYRILVEILAPA 1113

  Fly  1210 PVFYFCLMLVPITTLL 1225
            |:::....||.:||:|
plant  1114 PIYWIATFLVTVTTVL 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	25/66 (38%)
		ATPase-Plipid	229..1247	CDD:273734	435/1088 (40%)
		E1-E2_ATPase	286..>371	CDD:278548	37/90 (41%)
		Cation_ATPase	645..741	CDD:289987	45/102 (44%)
		HAD_like	<942..1001	CDD:304363	39/58 (67%)
		PhoLip_ATPase_C	988..1240	CDD:292829	80/243 (33%)
AT1G17500	NP_001319028.1	ATPase-Plipid	58..1151	CDD:273734	435/1088 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	281	1.000	Domainoid score	I393
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	827	1.000	Inparanoid score	I77
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	1	1.000	-	-		otm2889
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840